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Gene: HIST1H2AI |
Gene summary for HIST1H2AI |
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Gene information | Species | Human | Gene symbol | HIST1H2AI | Gene ID | 8329 |
Gene name | H2A clustered histone 13 | |
Gene Alias | H2A/c | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A4FTV9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8329 | HIST1H2AI | LZE4T | Human | Esophagus | ESCC | 4.53e-04 | 5.07e-01 | 0.0811 |
8329 | HIST1H2AI | LZE20T | Human | Esophagus | ESCC | 2.95e-06 | 2.40e-01 | 0.0662 |
8329 | HIST1H2AI | LZE21D1 | Human | Esophagus | HGIN | 2.75e-06 | 6.26e-01 | 0.0632 |
8329 | HIST1H2AI | LZE24T | Human | Esophagus | ESCC | 4.35e-08 | 3.04e-01 | 0.0596 |
8329 | HIST1H2AI | LZE21T | Human | Esophagus | ESCC | 1.16e-05 | 4.49e-01 | 0.0655 |
8329 | HIST1H2AI | LZE6T | Human | Esophagus | ESCC | 9.61e-05 | 2.35e-01 | 0.0845 |
8329 | HIST1H2AI | P1T-E | Human | Esophagus | ESCC | 7.43e-09 | 3.82e-01 | 0.0875 |
8329 | HIST1H2AI | P2T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.27e-01 | 0.1177 |
8329 | HIST1H2AI | P4T-E | Human | Esophagus | ESCC | 3.48e-08 | 2.22e-01 | 0.1323 |
8329 | HIST1H2AI | P8T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.49e-01 | 0.0889 |
8329 | HIST1H2AI | P9T-E | Human | Esophagus | ESCC | 4.01e-04 | 1.82e-01 | 0.1131 |
8329 | HIST1H2AI | P10T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.44e-01 | 0.116 |
8329 | HIST1H2AI | P12T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.06e-01 | 0.1122 |
8329 | HIST1H2AI | P15T-E | Human | Esophagus | ESCC | 1.35e-04 | 1.92e-01 | 0.1149 |
8329 | HIST1H2AI | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 3.15e-01 | 0.1278 |
8329 | HIST1H2AI | P20T-E | Human | Esophagus | ESCC | 2.72e-14 | 4.48e-01 | 0.1124 |
8329 | HIST1H2AI | P22T-E | Human | Esophagus | ESCC | 2.27e-21 | 7.10e-01 | 0.1236 |
8329 | HIST1H2AI | P23T-E | Human | Esophagus | ESCC | 6.53e-09 | 3.50e-01 | 0.108 |
8329 | HIST1H2AI | P24T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.29e-01 | 0.1287 |
8329 | HIST1H2AI | P26T-E | Human | Esophagus | ESCC | 9.02e-11 | 3.04e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2AI | SNV | Missense_Mutation | c.34N>G | p.Arg12Gly | p.R12G | P0C0S8 | protein_coding | deleterious_low_confidence(0.04) | benign(0.231) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2AI | SNV | Missense_Mutation | novel | c.250N>A | p.Leu84Ile | p.L84I | P0C0S8 | protein_coding | tolerated_low_confidence(0.26) | benign(0.354) | TCGA-21-5786-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
HIST1H2AI | SNV | Missense_Mutation | novel | c.5C>G | p.Ser2Cys | p.S2C | P0C0S8 | protein_coding | deleterious_low_confidence(0.02) | benign(0.091) | TCGA-77-A5GH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HIST1H2AI | SNV | Missense_Mutation | novel | c.186G>C | p.Glu62Asp | p.E62D | P0C0S8 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.915) | TCGA-85-8666-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HIST1H2AI | SNV | Missense_Mutation | novel | c.89G>C | p.Arg30Pro | p.R30P | P0C0S8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-98-8020-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
HIST1H2AI | SNV | Missense_Mutation | novel | c.364G>C | p.Glu122Gln | p.E122Q | P0C0S8 | protein_coding | tolerated_low_confidence(0.07) | benign(0.006) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
HIST1H2AI | SNV | Missense_Mutation | rs768930206 | c.5N>T | p.Ser2Phe | p.S2F | P0C0S8 | protein_coding | deleterious_low_confidence(0.01) | benign(0.047) | TCGA-QK-A8Z7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
HIST1H2AI | SNV | Missense_Mutation | novel | c.244N>T | p.Arg82Cys | p.R82C | P0C0S8 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.819) | TCGA-4L-AA1F-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Hormone Therapy | zoladex | SD |
HIST1H2AI | SNV | Missense_Mutation | rs755363997 | c.32N>T | p.Ala11Val | p.A11V | P0C0S8 | protein_coding | tolerated_low_confidence(0.2) | benign(0) | TCGA-EJ-7327-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
HIST1H2AI | SNV | Missense_Mutation | novel | c.8N>A | p.Gly3Glu | p.G3E | P0C0S8 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.932) | TCGA-RD-A8N9-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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