Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/HEPH_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/HEPH_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/HEPH_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0055076 | Colorectum | AD | transition metal ion homeostasis | 53/3918 | 138/18723 | 1.89e-06 | 5.65e-05 | 53 |
GO:0046916 | Colorectum | AD | cellular transition metal ion homeostasis | 43/3918 | 115/18723 | 3.62e-05 | 6.56e-04 | 43 |
GO:0055072 | Colorectum | AD | iron ion homeostasis | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:0006879 | Colorectum | AD | cellular iron ion homeostasis | 25/3918 | 67/18723 | 1.51e-03 | 1.27e-02 | 25 |
GO:00550761 | Colorectum | SER | transition metal ion homeostasis | 41/2897 | 138/18723 | 1.66e-05 | 5.05e-04 | 41 |
GO:00469161 | Colorectum | SER | cellular transition metal ion homeostasis | 33/2897 | 115/18723 | 2.20e-04 | 3.89e-03 | 33 |
GO:00550721 | Colorectum | SER | iron ion homeostasis | 24/2897 | 85/18723 | 1.91e-03 | 1.93e-02 | 24 |
GO:00550762 | Colorectum | MSS | transition metal ion homeostasis | 45/3467 | 138/18723 | 4.99e-05 | 9.02e-04 | 45 |
GO:00550722 | Colorectum | MSS | iron ion homeostasis | 29/3467 | 85/18723 | 4.44e-04 | 5.32e-03 | 29 |
GO:00469162 | Colorectum | MSS | cellular transition metal ion homeostasis | 35/3467 | 115/18723 | 1.33e-03 | 1.26e-02 | 35 |
GO:00068791 | Colorectum | MSS | cellular iron ion homeostasis | 22/3467 | 67/18723 | 3.57e-03 | 2.64e-02 | 22 |
GO:00550764 | Colorectum | FAP | transition metal ion homeostasis | 33/2622 | 138/18723 | 1.22e-03 | 1.14e-02 | 33 |
GO:00550723 | Colorectum | FAP | iron ion homeostasis | 21/2622 | 85/18723 | 5.89e-03 | 3.75e-02 | 21 |
GO:005507610 | Oral cavity | OSCC | transition metal ion homeostasis | 81/7305 | 138/18723 | 2.13e-06 | 2.72e-05 | 81 |
GO:00469168 | Oral cavity | OSCC | cellular transition metal ion homeostasis | 64/7305 | 115/18723 | 2.13e-04 | 1.40e-03 | 64 |
GO:00550728 | Oral cavity | OSCC | iron ion homeostasis | 46/7305 | 85/18723 | 3.31e-03 | 1.42e-02 | 46 |
GO:00550765 | Stomach | GC | transition metal ion homeostasis | 19/1159 | 138/18723 | 8.62e-04 | 1.07e-02 | 19 |
GO:0000041 | Stomach | GC | transition metal ion transport | 15/1159 | 105/18723 | 2.01e-03 | 2.03e-02 | 15 |
GO:00469163 | Stomach | GC | cellular transition metal ion homeostasis | 15/1159 | 115/18723 | 4.87e-03 | 3.89e-02 | 15 |
GO:0006826 | Stomach | SIM | iron ion transport | 7/708 | 58/18723 | 6.05e-03 | 4.83e-02 | 7 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HEPH | SNV | Missense_Mutation | novel | c.487N>A | p.Asp163Asn | p.D163N | Q9BQS7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HEPH | SNV | Missense_Mutation | | c.2758G>C | p.Glu920Gln | p.E920Q | Q9BQS7 | protein_coding | deleterious(0.04) | benign(0.334) | TCGA-C5-A2LV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HEPH | SNV | Missense_Mutation | novel | c.862G>A | p.Asp288Asn | p.D288N | Q9BQS7 | protein_coding | deleterious(0.03) | probably_damaging(0.948) | TCGA-EK-A2R7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HEPH | SNV | Missense_Mutation | | c.3424N>T | p.Ile1142Phe | p.I1142F | Q9BQS7 | protein_coding | tolerated(0.7) | benign(0) | TCGA-EK-A2RK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
HEPH | SNV | Missense_Mutation | | c.1985C>T | p.Ser662Leu | p.S662L | Q9BQS7 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HEPH | SNV | Missense_Mutation | | c.3196N>T | p.Arg1066Trp | p.R1066W | Q9BQS7 | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
HEPH | SNV | Missense_Mutation | novel | c.2854N>A | p.Gly952Arg | p.G952R | Q9BQS7 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
HEPH | insertion | Frame_Shift_Ins | novel | c.3540dupT | p.Gly1181TrpfsTer17 | p.G1181Wfs*17 | Q9BQS7 | protein_coding | | | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HEPH | insertion | Frame_Shift_Ins | novel | c.2380_2381insA | p.Glu795ArgfsTer9 | p.E795Rfs*9 | Q9BQS7 | protein_coding | | | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
HEPH | SNV | Missense_Mutation | | c.2182N>T | p.Ala728Ser | p.A728S | Q9BQS7 | protein_coding | tolerated(0.41) | benign(0.005) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |