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Gene: HELB |
Gene summary for HELB |
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Gene information | Species | Human | Gene symbol | HELB | Gene ID | 92797 |
Gene name | DNA helicase B | |
Gene Alias | DHB | |
Cytomap | 12q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q8NG08 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92797 | HELB | CCI_2 | Human | Cervix | CC | 1.77e-11 | 5.66e-01 | 0.5249 |
92797 | HELB | CCI_3 | Human | Cervix | CC | 1.13e-15 | 6.56e-01 | 0.516 |
92797 | HELB | T1 | Human | Cervix | CC | 1.68e-02 | 1.26e-01 | 0.0918 |
92797 | HELB | AEH-subject1 | Human | Endometrium | AEH | 2.06e-08 | 3.11e-01 | -0.3059 |
92797 | HELB | LZE4T | Human | Esophagus | ESCC | 3.68e-11 | 3.28e-01 | 0.0811 |
92797 | HELB | LZE5T | Human | Esophagus | ESCC | 9.05e-03 | 2.06e-01 | 0.0514 |
92797 | HELB | LZE8T | Human | Esophagus | ESCC | 3.73e-03 | 1.16e-01 | 0.067 |
92797 | HELB | LZE24T | Human | Esophagus | ESCC | 9.64e-05 | 1.47e-01 | 0.0596 |
92797 | HELB | P1T-E | Human | Esophagus | ESCC | 2.91e-02 | 2.43e-01 | 0.0875 |
92797 | HELB | P2T-E | Human | Esophagus | ESCC | 2.93e-33 | 6.05e-01 | 0.1177 |
92797 | HELB | P4T-E | Human | Esophagus | ESCC | 3.35e-02 | 1.19e-01 | 0.1323 |
92797 | HELB | P5T-E | Human | Esophagus | ESCC | 7.12e-06 | 1.10e-01 | 0.1327 |
92797 | HELB | P8T-E | Human | Esophagus | ESCC | 1.91e-19 | 3.52e-01 | 0.0889 |
92797 | HELB | P9T-E | Human | Esophagus | ESCC | 1.44e-04 | 8.44e-02 | 0.1131 |
92797 | HELB | P10T-E | Human | Esophagus | ESCC | 1.31e-05 | 5.60e-02 | 0.116 |
92797 | HELB | P11T-E | Human | Esophagus | ESCC | 2.14e-06 | 2.20e-01 | 0.1426 |
92797 | HELB | P12T-E | Human | Esophagus | ESCC | 2.30e-11 | 7.14e-02 | 0.1122 |
92797 | HELB | P15T-E | Human | Esophagus | ESCC | 9.54e-05 | 1.47e-01 | 0.1149 |
92797 | HELB | P16T-E | Human | Esophagus | ESCC | 2.67e-18 | 2.14e-01 | 0.1153 |
92797 | HELB | P21T-E | Human | Esophagus | ESCC | 4.06e-09 | 1.44e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004227410 | Cervix | CC | ribosomal small subunit biogenesis | 23/2311 | 73/18723 | 1.33e-05 | 2.68e-04 | 23 |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:20010209 | Cervix | CC | regulation of response to DNA damage stimulus | 46/2311 | 219/18723 | 1.92e-04 | 2.23e-03 | 46 |
GO:00510528 | Cervix | CC | regulation of DNA metabolic process | 65/2311 | 359/18723 | 9.25e-04 | 7.84e-03 | 65 |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:00323923 | Cervix | CC | DNA geometric change | 21/2311 | 90/18723 | 2.71e-03 | 1.85e-02 | 21 |
GO:00160727 | Cervix | CC | rRNA metabolic process | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
GO:004227416 | Endometrium | AEH | ribosomal small subunit biogenesis | 22/2100 | 73/18723 | 9.73e-06 | 2.24e-04 | 22 |
GO:00063648 | Endometrium | AEH | rRNA processing | 47/2100 | 225/18723 | 1.78e-05 | 3.65e-04 | 47 |
GO:00160728 | Endometrium | AEH | rRNA metabolic process | 48/2100 | 236/18723 | 3.01e-05 | 5.54e-04 | 48 |
GO:200102010 | Endometrium | AEH | regulation of response to DNA damage stimulus | 40/2100 | 219/18723 | 1.28e-03 | 1.09e-02 | 40 |
GO:00344707 | Endometrium | AEH | ncRNA processing | 62/2100 | 395/18723 | 3.93e-03 | 2.65e-02 | 62 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HELB | SNV | Missense_Mutation | c.2305N>G | p.Gln769Glu | p.Q769E | Q8NG08 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
HELB | SNV | Missense_Mutation | c.3237N>G | p.Phe1079Leu | p.F1079L | Q8NG08 | protein_coding | deleterious(0.02) | benign(0.056) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
HELB | SNV | Missense_Mutation | novel | c.470N>C | p.Leu157Pro | p.L157P | Q8NG08 | protein_coding | deleterious(0.02) | benign(0.081) | TCGA-VS-A9V4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
HELB | SNV | Missense_Mutation | novel | c.304N>C | p.Tyr102His | p.Y102H | Q8NG08 | protein_coding | tolerated(0.42) | benign(0.046) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HELB | SNV | Missense_Mutation | c.1262N>T | p.Thr421Ile | p.T421I | Q8NG08 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HELB | SNV | Missense_Mutation | rs139082430 | c.2716C>T | p.Arg906Cys | p.R906C | Q8NG08 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HELB | SNV | Missense_Mutation | novel | c.3221T>C | p.Ile1074Thr | p.I1074T | Q8NG08 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HELB | SNV | Missense_Mutation | c.1090N>A | p.Ala364Thr | p.A364T | Q8NG08 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HELB | SNV | Missense_Mutation | rs768747696 | c.2012G>A | p.Arg671His | p.R671H | Q8NG08 | protein_coding | deleterious(0.03) | probably_damaging(0.938) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HELB | SNV | Missense_Mutation | c.1195N>A | p.Asp399Asn | p.D399N | Q8NG08 | protein_coding | tolerated(0.16) | benign(0.111) | TCGA-AZ-6603-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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