GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001623616 | Esophagus | HGIN | macroautophagy | 77/2587 | 291/18723 | 7.15e-09 | 4.61e-07 | 77 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:005105214 | Esophagus | HGIN | regulation of DNA metabolic process | 79/2587 | 359/18723 | 1.38e-05 | 3.85e-04 | 79 |
GO:200102019 | Esophagus | HGIN | regulation of response to DNA damage stimulus | 52/2587 | 219/18723 | 5.00e-05 | 1.19e-03 | 52 |
GO:005105416 | Esophagus | HGIN | positive regulation of DNA metabolic process | 47/2587 | 201/18723 | 1.65e-04 | 3.21e-03 | 47 |
GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:005105417 | Esophagus | ESCC | positive regulation of DNA metabolic process | 139/8552 | 201/18723 | 1.20e-11 | 4.33e-10 | 139 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:20010228 | Esophagus | ESCC | positive regulation of response to DNA damage stimulus | 69/8552 | 105/18723 | 2.66e-05 | 2.22e-04 | 69 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC10 | SNV | Missense_Mutation | novel | c.1639N>T | p.Pro547Ser | p.P547S | Q969S8 | protein_coding | tolerated(0.25) | benign(0.052) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
HDAC10 | SNV | Missense_Mutation | rs753565928 | c.1936G>A | p.Ala646Thr | p.A646T | Q969S8 | protein_coding | tolerated(0.09) | benign(0.027) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HDAC10 | SNV | Missense_Mutation | rs201412860 | c.1525N>A | p.Val509Met | p.V509M | Q969S8 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC10 | SNV | Missense_Mutation | novel | c.598N>T | p.Gly200Trp | p.G200W | Q969S8 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDAC10 | SNV | Missense_Mutation | novel | c.2005N>A | p.Ala669Thr | p.A669T | Q969S8 | protein_coding | deleterious_low_confidence(0) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC10 | SNV | Missense_Mutation | novel | c.1258N>A | p.Asp420Asn | p.D420N | Q969S8 | protein_coding | tolerated(0.09) | benign(0.276) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC10 | SNV | Missense_Mutation | | c.847N>A | p.Ala283Thr | p.A283T | Q969S8 | protein_coding | deleterious(0) | probably_damaging(0.909) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC10 | SNV | Missense_Mutation | novel | c.877N>A | p.Ala293Thr | p.A293T | Q969S8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC10 | SNV | Missense_Mutation | novel | c.1517T>C | p.Leu506Pro | p.L506P | Q969S8 | protein_coding | deleterious(0) | possibly_damaging(0.851) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
HDAC10 | SNV | Missense_Mutation | | c.818N>A | p.Gly273Glu | p.G273E | Q969S8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | | APICIDIN | APICIDIN | 19705846 |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | 187051805 | QUISINOSTAT | |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | | BUTYRYLHYDROXAMIC ACID | BUTYRYLHYDROXAMIC ACID | 21874153 |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | | RESMINOSTAT | RESMINOSTAT | |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | 348353623 | | |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | | BELINOSTAT | BELINOSTAT | |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | | PRACINOSTAT | PRACINOSTAT | |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | | ENTINOSTAT | ENTINOSTAT | 19966789,20491440 |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | | MOCETINOSTAT | MOCETINOSTAT | 23829483,26287310 |
83933 | HDAC10 | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | GIVINOSTAT | GIVINOSTAT | |