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Gene: GTPBP6 |
Gene summary for GTPBP6 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GTPBP6 | Gene ID | 8225 |
Gene name | GTP binding protein 6 (putative) | |
Gene Alias | PGPL | |
Cytomap | X | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | H0Y2S1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8225 | GTPBP6 | LZE6T | Human | Esophagus | ESCC | 2.70e-02 | 8.23e-02 | 0.0845 |
8225 | GTPBP6 | P1T-E | Human | Esophagus | ESCC | 1.31e-06 | 4.84e-01 | 0.0875 |
8225 | GTPBP6 | P2T-E | Human | Esophagus | ESCC | 4.63e-61 | 9.85e-01 | 0.1177 |
8225 | GTPBP6 | P4T-E | Human | Esophagus | ESCC | 9.32e-30 | 7.33e-01 | 0.1323 |
8225 | GTPBP6 | P5T-E | Human | Esophagus | ESCC | 8.32e-16 | 4.02e-01 | 0.1327 |
8225 | GTPBP6 | P8T-E | Human | Esophagus | ESCC | 3.76e-12 | 2.85e-01 | 0.0889 |
8225 | GTPBP6 | P9T-E | Human | Esophagus | ESCC | 4.38e-09 | 1.52e-01 | 0.1131 |
8225 | GTPBP6 | P10T-E | Human | Esophagus | ESCC | 9.89e-12 | 1.87e-01 | 0.116 |
8225 | GTPBP6 | P11T-E | Human | Esophagus | ESCC | 1.16e-04 | 3.45e-01 | 0.1426 |
8225 | GTPBP6 | P12T-E | Human | Esophagus | ESCC | 2.13e-18 | 3.43e-01 | 0.1122 |
8225 | GTPBP6 | P15T-E | Human | Esophagus | ESCC | 1.28e-06 | 1.68e-01 | 0.1149 |
8225 | GTPBP6 | P16T-E | Human | Esophagus | ESCC | 1.32e-08 | 1.36e-01 | 0.1153 |
8225 | GTPBP6 | P17T-E | Human | Esophagus | ESCC | 4.17e-02 | 1.17e-01 | 0.1278 |
8225 | GTPBP6 | P20T-E | Human | Esophagus | ESCC | 2.02e-07 | 2.22e-01 | 0.1124 |
8225 | GTPBP6 | P21T-E | Human | Esophagus | ESCC | 2.74e-15 | 1.85e-01 | 0.1617 |
8225 | GTPBP6 | P22T-E | Human | Esophagus | ESCC | 1.44e-06 | 1.29e-01 | 0.1236 |
8225 | GTPBP6 | P23T-E | Human | Esophagus | ESCC | 7.47e-14 | 4.23e-01 | 0.108 |
8225 | GTPBP6 | P24T-E | Human | Esophagus | ESCC | 1.03e-02 | 7.93e-02 | 0.1287 |
8225 | GTPBP6 | P26T-E | Human | Esophagus | ESCC | 3.73e-16 | 3.70e-01 | 0.1276 |
8225 | GTPBP6 | P27T-E | Human | Esophagus | ESCC | 1.66e-20 | 4.07e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP6 | SNV | Missense_Mutation | rs374404792 | c.1361N>T | p.Ala454Val | p.A454V | protein_coding | tolerated(0.18) | benign(0.382) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP6 | SNV | Missense_Mutation | novel | c.1213N>A | p.Leu405Met | p.L405M | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP6 | SNV | Missense_Mutation | rs779588414 | c.692N>T | p.Ser231Leu | p.S231L | protein_coding | deleterious(0) | possibly_damaging(0.794) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
GTPBP6 | SNV | Missense_Mutation | novel | c.821N>T | p.Ala274Val | p.A274V | protein_coding | deleterious(0.04) | possibly_damaging(0.868) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP6 | SNV | Missense_Mutation | rs767254985 | c.859N>T | p.Arg287Trp | p.R287W | protein_coding | deleterious(0.01) | possibly_damaging(0.886) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GTPBP6 | SNV | Missense_Mutation | rs372049951 | c.869N>T | p.Thr290Met | p.T290M | protein_coding | tolerated(0.09) | benign(0.058) | TCGA-BG-A187-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP6 | SNV | Missense_Mutation | c.1315N>A | p.Leu439Met | p.L439M | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | ||
GTPBP6 | SNV | Missense_Mutation | c.1537N>A | p.Leu513Ile | p.L513I | protein_coding | tolerated(0.08) | probably_damaging(0.999) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GTPBP6 | SNV | Missense_Mutation | novel | c.1201C>A | p.Arg401Ser | p.R401S | protein_coding | tolerated(0.11) | possibly_damaging(0.686) | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
GTPBP6 | SNV | Missense_Mutation | novel | c.905N>G | p.Tyr302Cys | p.Y302C | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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