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Gene: GSG2 |
Gene summary for GSG2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GSG2 | Gene ID | 83903 |
Gene name | histone H3 associated protein kinase | |
Gene Alias | GSG2 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A0PJ70 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83903 | GSG2 | HCC2 | Human | Liver | HCC | 3.10e-11 | 5.90e-01 | 0.5341 |
83903 | GSG2 | HCC5 | Human | Liver | HCC | 1.23e-09 | 5.99e-01 | 0.4932 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSG2 | SNV | Missense_Mutation | c.2078N>C | p.Leu693Ser | p.L693S | Q8TF76 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
GSG2 | SNV | Missense_Mutation | c.936N>T | p.Glu312Asp | p.E312D | Q8TF76 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
GSG2 | SNV | Missense_Mutation | novel | c.1325N>T | p.Tyr442Phe | p.Y442F | Q8TF76 | protein_coding | tolerated(0.06) | benign(0.261) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSG2 | SNV | Missense_Mutation | c.1909G>A | p.Ala637Thr | p.A637T | Q8TF76 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GSG2 | SNV | Missense_Mutation | c.2348A>C | p.Asn783Thr | p.N783T | Q8TF76 | protein_coding | tolerated(0.3) | benign(0.018) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
GSG2 | SNV | Missense_Mutation | c.2227C>T | p.Leu743Phe | p.L743F | Q8TF76 | protein_coding | tolerated(0.06) | possibly_damaging(0.708) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GSG2 | SNV | Missense_Mutation | rs533560843 | c.923C>T | p.Ala308Val | p.A308V | Q8TF76 | protein_coding | tolerated(0.09) | benign(0.014) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GSG2 | SNV | Missense_Mutation | rs150287837 | c.1654C>T | p.Arg552Cys | p.R552C | Q8TF76 | protein_coding | tolerated(0.08) | benign(0.125) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
GSG2 | SNV | Missense_Mutation | novel | c.1609N>C | p.Ile537Leu | p.I537L | Q8TF76 | protein_coding | deleterious(0.03) | possibly_damaging(0.77) | TCGA-AG-A023-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GSG2 | insertion | Frame_Shift_Ins | novel | c.1826_1827insGATTGACTTAGAGCAAATGCGAACCAAGTTGTCTTCCTTGGTTT | p.Ala623ValfsTer2 | p.A623Vfs*2 | Q8TF76 | protein_coding | TCGA-DM-A0XD-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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