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Gene: GSG1 |
Gene summary for GSG1 |
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Gene information | Species | Human | Gene symbol | GSG1 | Gene ID | 83445 |
Gene name | germ cell associated 1 | |
Gene Alias | GSG1 | |
Cytomap | 12p13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | F1T0A1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83445 | GSG1 | HCC1 | Human | Liver | HCC | 1.33e-05 | 4.65e-01 | 0.5336 |
83445 | GSG1 | HCC2 | Human | Liver | HCC | 3.91e-14 | 1.20e+00 | 0.5341 |
83445 | GSG1 | HCC5 | Human | Liver | HCC | 2.42e-07 | 9.11e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSG1 | SNV | Missense_Mutation | rs762192462 | c.794C>T | p.Pro265Leu | p.P265L | Q2KHT4 | protein_coding | tolerated(1) | benign(0.006) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GSG1 | SNV | Missense_Mutation | rs199755415 | c.319C>T | p.Arg107Trp | p.R107W | Q2KHT4 | protein_coding | tolerated(0.07) | benign(0.009) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GSG1 | SNV | Missense_Mutation | rs199755415 | c.319N>T | p.Arg107Trp | p.R107W | Q2KHT4 | protein_coding | tolerated(0.07) | benign(0.009) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GSG1 | SNV | Missense_Mutation | rs772239685 | c.713C>T | p.Ser238Leu | p.S238L | Q2KHT4 | protein_coding | deleterious(0.02) | benign(0.132) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
GSG1 | SNV | Missense_Mutation | c.67N>G | p.Phe23Val | p.F23V | Q2KHT4 | protein_coding | tolerated(0.26) | benign(0.005) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
GSG1 | SNV | Missense_Mutation | rs558298554 | c.829C>T | p.Arg277Trp | p.R277W | Q2KHT4 | protein_coding | deleterious(0) | possibly_damaging(0.719) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
GSG1 | SNV | Missense_Mutation | rs769586584 | c.515C>T | p.Ala172Val | p.A172V | Q2KHT4 | protein_coding | tolerated(0.78) | benign(0.001) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
GSG1 | SNV | Missense_Mutation | novel | c.69C>A | p.Phe23Leu | p.F23L | Q2KHT4 | protein_coding | tolerated(0.59) | benign(0.001) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
GSG1 | SNV | Missense_Mutation | novel | c.590N>C | p.Met197Thr | p.M197T | Q2KHT4 | protein_coding | deleterious(0.04) | benign(0.023) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSG1 | SNV | Missense_Mutation | rs772207656 | c.7G>T | p.Asp3Tyr | p.D3Y | Q2KHT4 | protein_coding | deleterious_low_confidence(0.02) | benign(0.215) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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