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Gene: GRPEL2 |
Gene summary for GRPEL2 |
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Gene information | Species | Human | Gene symbol | GRPEL2 | Gene ID | 134266 |
Gene name | GrpE like 2, mitochondrial | |
Gene Alias | Mt-GrpE#2 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q8TAA5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
134266 | GRPEL2 | HCC1_Meng | Human | Liver | HCC | 2.68e-28 | 5.10e-02 | 0.0246 |
134266 | GRPEL2 | HCC1 | Human | Liver | HCC | 1.13e-05 | 1.24e+00 | 0.5336 |
134266 | GRPEL2 | HCC2 | Human | Liver | HCC | 9.04e-06 | 2.54e+00 | 0.5341 |
134266 | GRPEL2 | S014 | Human | Liver | HCC | 2.93e-08 | 2.68e-01 | 0.2254 |
134266 | GRPEL2 | S015 | Human | Liver | HCC | 1.53e-08 | 2.92e-01 | 0.2375 |
134266 | GRPEL2 | S016 | Human | Liver | HCC | 2.43e-05 | 2.62e-01 | 0.2243 |
134266 | GRPEL2 | S027 | Human | Liver | HCC | 4.33e-04 | 3.81e-01 | 0.2446 |
134266 | GRPEL2 | S028 | Human | Liver | HCC | 1.99e-08 | 3.58e-01 | 0.2503 |
134266 | GRPEL2 | S029 | Human | Liver | HCC | 8.96e-07 | 3.61e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:007265512 | Liver | HCC | establishment of protein localization to mitochondrion | 98/7958 | 120/18723 | 1.18e-18 | 1.46e-16 | 98 |
GO:007058512 | Liver | HCC | protein localization to mitochondrion | 101/7958 | 125/18723 | 1.53e-18 | 1.86e-16 | 101 |
GO:000662612 | Liver | HCC | protein targeting to mitochondrion | 82/7958 | 100/18723 | 4.93e-16 | 4.05e-14 | 82 |
GO:001703811 | Liver | HCC | protein import | 140/7958 | 206/18723 | 1.12e-13 | 6.46e-12 | 140 |
GO:199054212 | Liver | HCC | mitochondrial transmembrane transport | 78/7958 | 102/18723 | 2.73e-12 | 1.26e-10 | 78 |
GO:007180611 | Liver | HCC | protein transmembrane transport | 47/7958 | 59/18723 | 5.82e-09 | 1.51e-07 | 47 |
GO:006500211 | Liver | HCC | intracellular protein transmembrane transport | 41/7958 | 51/18723 | 3.41e-08 | 7.61e-07 | 41 |
GO:00447431 | Liver | HCC | protein transmembrane import into intracellular organelle | 29/7958 | 36/18723 | 3.42e-06 | 4.49e-05 | 29 |
GO:00301501 | Liver | HCC | protein import into mitochondrial matrix | 17/7958 | 20/18723 | 1.18e-04 | 9.87e-04 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRPEL2 | SNV | Missense_Mutation | novel | c.118N>A | p.Ala40Thr | p.A40T | Q8TAA5 | protein_coding | tolerated(0.76) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
GRPEL2 | SNV | Missense_Mutation | rs141968352 | c.623N>A | p.Arg208His | p.R208H | Q8TAA5 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRPEL2 | SNV | Missense_Mutation | rs867201109 | c.392N>T | p.Ser131Leu | p.S131L | Q8TAA5 | protein_coding | tolerated(0.11) | benign(0.015) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRPEL2 | SNV | Missense_Mutation | rs867201109 | c.392C>T | p.Ser131Leu | p.S131L | Q8TAA5 | protein_coding | tolerated(0.11) | benign(0.015) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRPEL2 | SNV | Missense_Mutation | c.65C>G | p.Ala22Gly | p.A22G | Q8TAA5 | protein_coding | tolerated(0.12) | benign(0.028) | TCGA-K7-A6G5-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GRPEL2 | SNV | Missense_Mutation | c.559G>T | p.Gly187Cys | p.G187C | Q8TAA5 | protein_coding | deleterious(0) | possibly_damaging(0.65) | TCGA-56-5898-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GRPEL2 | SNV | Missense_Mutation | novel | c.659A>G | p.Glu220Gly | p.E220G | Q8TAA5 | protein_coding | tolerated(0.05) | probably_damaging(0.941) | TCGA-94-A4VJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRPEL2 | SNV | Missense_Mutation | rs759368363 | c.666G>C | p.Gln222His | p.Q222H | Q8TAA5 | protein_coding | tolerated(0.12) | benign(0.092) | TCGA-96-7544-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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