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Gene: GRASP |
Gene summary for GRASP |
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Gene information | Species | Human | Gene symbol | GRASP | Gene ID | 160622 |
Gene name | trafficking regulator and scaffold protein tamalin | |
Gene Alias | GRASP | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q7Z6J2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
160622 | GRASP | P1T-E | Human | Esophagus | ESCC | 4.01e-05 | 3.15e-01 | 0.0875 |
160622 | GRASP | P2T-E | Human | Esophagus | ESCC | 3.86e-14 | 3.09e-01 | 0.1177 |
160622 | GRASP | P4T-E | Human | Esophagus | ESCC | 4.83e-12 | 3.48e-01 | 0.1323 |
160622 | GRASP | P8T-E | Human | Esophagus | ESCC | 5.79e-04 | -1.58e-02 | 0.0889 |
160622 | GRASP | P10T-E | Human | Esophagus | ESCC | 2.01e-05 | 7.03e-02 | 0.116 |
160622 | GRASP | P11T-E | Human | Esophagus | ESCC | 1.22e-03 | 1.43e-01 | 0.1426 |
160622 | GRASP | P12T-E | Human | Esophagus | ESCC | 2.19e-05 | 1.15e-01 | 0.1122 |
160622 | GRASP | P15T-E | Human | Esophagus | ESCC | 3.46e-04 | 3.14e-02 | 0.1149 |
160622 | GRASP | P16T-E | Human | Esophagus | ESCC | 2.09e-04 | 1.25e-01 | 0.1153 |
160622 | GRASP | P20T-E | Human | Esophagus | ESCC | 9.36e-10 | 2.30e-01 | 0.1124 |
160622 | GRASP | P21T-E | Human | Esophagus | ESCC | 8.83e-03 | -1.97e-02 | 0.1617 |
160622 | GRASP | P22T-E | Human | Esophagus | ESCC | 8.07e-03 | 1.40e-01 | 0.1236 |
160622 | GRASP | P24T-E | Human | Esophagus | ESCC | 6.01e-03 | 1.83e-02 | 0.1287 |
160622 | GRASP | P27T-E | Human | Esophagus | ESCC | 2.45e-15 | 4.78e-01 | 0.1055 |
160622 | GRASP | P28T-E | Human | Esophagus | ESCC | 8.04e-09 | 2.43e-01 | 0.1149 |
160622 | GRASP | P42T-E | Human | Esophagus | ESCC | 2.82e-10 | 1.28e-01 | 0.1175 |
160622 | GRASP | P47T-E | Human | Esophagus | ESCC | 6.54e-04 | 3.43e-02 | 0.1067 |
160622 | GRASP | P48T-E | Human | Esophagus | ESCC | 1.72e-03 | 1.21e-01 | 0.0959 |
160622 | GRASP | P49T-E | Human | Esophagus | ESCC | 7.98e-04 | 5.22e-01 | 0.1768 |
160622 | GRASP | P54T-E | Human | Esophagus | ESCC | 6.69e-09 | 3.04e-01 | 0.0975 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRASP | SNV | Missense_Mutation | c.544N>A | p.Leu182Ile | p.L182I | Q7Z6J2 | protein_coding | tolerated(0.18) | possibly_damaging(0.557) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
GRASP | SNV | Missense_Mutation | rs781593097 | c.577C>T | p.Arg193Trp | p.R193W | Q7Z6J2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GRASP | SNV | Missense_Mutation | novel | c.365N>G | p.His122Arg | p.H122R | Q7Z6J2 | protein_coding | deleterious(0) | benign(0.284) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GRASP | SNV | Missense_Mutation | rs764484127 | c.382C>T | p.Arg128Cys | p.R128C | Q7Z6J2 | protein_coding | deleterious(0.02) | possibly_damaging(0.832) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRASP | insertion | Frame_Shift_Ins | novel | c.360_361insGG | p.Leu121GlyfsTer13 | p.L121Gfs*13 | Q7Z6J2 | protein_coding | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | ||
GRASP | insertion | Frame_Shift_Ins | novel | c.361_362insTCCATGAGGCTGATTTCAATTGGGTATGGGAAAGACA | p.His123GlufsTer30 | p.H123Efs*30 | Q7Z6J2 | protein_coding | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | ||
GRASP | SNV | Missense_Mutation | novel | c.159N>A | p.Asp53Glu | p.D53E | Q7Z6J2 | protein_coding | tolerated(0.6) | benign(0) | TCGA-DD-AAE9-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GRASP | SNV | Missense_Mutation | c.317N>T | p.Lys106Met | p.K106M | Q7Z6J2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-66-2734-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GRASP | SNV | Missense_Mutation | novel | c.173C>T | p.Ala58Val | p.A58V | Q7Z6J2 | protein_coding | tolerated(0.13) | possibly_damaging(0.689) | TCGA-CV-A463-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRASP | SNV | Missense_Mutation | c.643N>C | p.Tyr215His | p.Y215H | Q7Z6J2 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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