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Gene: GPX7 |
Gene summary for GPX7 |
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Gene information | Species | Human | Gene symbol | GPX7 | Gene ID | 2882 |
Gene name | glutathione peroxidase 7 | |
Gene Alias | CL683 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | Q96SL4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2882 | GPX7 | LZE7T | Human | Esophagus | ESCC | 8.65e-05 | 2.53e-01 | 0.0667 |
2882 | GPX7 | LZE8T | Human | Esophagus | ESCC | 5.39e-05 | 1.92e-01 | 0.067 |
2882 | GPX7 | LZE24T | Human | Esophagus | ESCC | 4.70e-13 | 3.05e-01 | 0.0596 |
2882 | GPX7 | LZE6T | Human | Esophagus | ESCC | 1.59e-10 | 5.11e-01 | 0.0845 |
2882 | GPX7 | P2T-E | Human | Esophagus | ESCC | 2.31e-32 | 5.99e-01 | 0.1177 |
2882 | GPX7 | P4T-E | Human | Esophagus | ESCC | 8.18e-35 | 7.55e-01 | 0.1323 |
2882 | GPX7 | P5T-E | Human | Esophagus | ESCC | 8.57e-07 | 2.42e-01 | 0.1327 |
2882 | GPX7 | P8T-E | Human | Esophagus | ESCC | 1.97e-39 | 6.98e-01 | 0.0889 |
2882 | GPX7 | P9T-E | Human | Esophagus | ESCC | 2.43e-10 | 2.72e-01 | 0.1131 |
2882 | GPX7 | P10T-E | Human | Esophagus | ESCC | 2.97e-49 | 9.73e-01 | 0.116 |
2882 | GPX7 | P12T-E | Human | Esophagus | ESCC | 4.82e-43 | 8.04e-01 | 0.1122 |
2882 | GPX7 | P15T-E | Human | Esophagus | ESCC | 2.53e-14 | 3.55e-01 | 0.1149 |
2882 | GPX7 | P16T-E | Human | Esophagus | ESCC | 1.27e-44 | 9.50e-01 | 0.1153 |
2882 | GPX7 | P19T-E | Human | Esophagus | ESCC | 1.22e-02 | 3.14e-01 | 0.1662 |
2882 | GPX7 | P20T-E | Human | Esophagus | ESCC | 3.08e-21 | 4.78e-01 | 0.1124 |
2882 | GPX7 | P21T-E | Human | Esophagus | ESCC | 8.21e-19 | 3.97e-01 | 0.1617 |
2882 | GPX7 | P24T-E | Human | Esophagus | ESCC | 3.91e-09 | 2.15e-01 | 0.1287 |
2882 | GPX7 | P26T-E | Human | Esophagus | ESCC | 3.83e-08 | 2.15e-01 | 0.1276 |
2882 | GPX7 | P27T-E | Human | Esophagus | ESCC | 4.03e-19 | 3.67e-01 | 0.1055 |
2882 | GPX7 | P28T-E | Human | Esophagus | ESCC | 1.38e-29 | 5.46e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:1990748110 | Esophagus | ESCC | cellular detoxification | 70/8552 | 116/18723 | 1.02e-03 | 5.17e-03 | 70 |
GO:0097237110 | Esophagus | ESCC | cellular response to toxic substance | 72/8552 | 124/18723 | 3.65e-03 | 1.49e-02 | 72 |
GO:0098869110 | Esophagus | ESCC | cellular oxidant detoxification | 60/8552 | 101/18723 | 3.76e-03 | 1.53e-02 | 60 |
GO:000697912 | Liver | Cirrhotic | response to oxidative stress | 196/4634 | 446/18723 | 2.80e-19 | 5.86e-17 | 196 |
GO:006219712 | Liver | Cirrhotic | cellular response to chemical stress | 147/4634 | 337/18723 | 1.84e-14 | 1.72e-12 | 147 |
GO:003459912 | Liver | Cirrhotic | cellular response to oxidative stress | 127/4634 | 288/18723 | 4.29e-13 | 3.32e-11 | 127 |
GO:000963612 | Liver | Cirrhotic | response to toxic substance | 104/4634 | 262/18723 | 5.63e-08 | 1.74e-06 | 104 |
GO:00987547 | Liver | Cirrhotic | detoxification | 60/4634 | 152/18723 | 4.09e-05 | 4.86e-04 | 60 |
GO:00972377 | Liver | Cirrhotic | cellular response to toxic substance | 50/4634 | 124/18723 | 9.20e-05 | 9.79e-04 | 50 |
GO:19907487 | Liver | Cirrhotic | cellular detoxification | 47/4634 | 116/18723 | 1.28e-04 | 1.26e-03 | 47 |
GO:00988697 | Liver | Cirrhotic | cellular oxidant detoxification | 38/4634 | 101/18723 | 2.72e-03 | 1.59e-02 | 38 |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:003459922 | Liver | HCC | cellular response to oxidative stress | 183/7958 | 288/18723 | 3.65e-13 | 1.93e-11 | 183 |
GO:000963622 | Liver | HCC | response to toxic substance | 153/7958 | 262/18723 | 1.37e-07 | 2.58e-06 | 153 |
GO:199074812 | Liver | HCC | cellular detoxification | 70/7958 | 116/18723 | 7.87e-05 | 7.02e-04 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0501614 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502214 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa004809 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
hsa0501615 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502215 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0048012 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
hsa0501622 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0048022 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPX7 | SNV | Missense_Mutation | c.206N>G | p.Gln69Arg | p.Q69R | Q96SL4 | protein_coding | tolerated(0.18) | benign(0.021) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPX7 | SNV | Missense_Mutation | novel | c.223G>T | p.Gly75Cys | p.G75C | Q96SL4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BS-A0VI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPX7 | SNV | Missense_Mutation | c.166N>A | p.Glu56Lys | p.E56K | Q96SL4 | protein_coding | tolerated(0.05) | benign(0.097) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GPX7 | SNV | Missense_Mutation | novel | c.415G>A | p.Glu139Lys | p.E139K | Q96SL4 | protein_coding | tolerated(0.06) | benign(0.161) | TCGA-44-4112-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GPX7 | SNV | Missense_Mutation | rs761068118 | c.314N>A | p.Arg105His | p.R105H | Q96SL4 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-71-6725-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GPX7 | SNV | Missense_Mutation | novel | c.513N>T | p.Gln171His | p.Q171H | Q96SL4 | protein_coding | tolerated(0.32) | benign(0) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
GPX7 | SNV | Missense_Mutation | novel | c.502N>A | p.Val168Ile | p.V168I | Q96SL4 | protein_coding | tolerated(1) | benign(0) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GPX7 | SNV | Missense_Mutation | novel | c.305N>A | p.Ser102Asn | p.S102N | Q96SL4 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPX7 | SNV | Missense_Mutation | rs763735633 | c.101N>A | p.Arg34Gln | p.R34Q | Q96SL4 | protein_coding | tolerated(0.06) | possibly_damaging(0.598) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GPX7 | SNV | Missense_Mutation | c.508N>A | p.Pro170Thr | p.P170T | Q96SL4 | protein_coding | deleterious(0.01) | benign(0.422) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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