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Gene: GPR87 |
Gene summary for GPR87 |
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Gene information | Species | Human | Gene symbol | GPR87 | Gene ID | 53836 |
Gene name | G protein-coupled receptor 87 | |
Gene Alias | FKSG78 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9BY21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
53836 | GPR87 | CCI_2 | Human | Cervix | CC | 3.22e-05 | 5.15e-01 | 0.5249 |
53836 | GPR87 | Tumor | Human | Cervix | CC | 1.18e-15 | 4.45e-01 | 0.1241 |
53836 | GPR87 | sample1 | Human | Cervix | CC | 9.20e-08 | 3.69e-01 | 0.0959 |
53836 | GPR87 | sample3 | Human | Cervix | CC | 4.35e-32 | 5.27e-01 | 0.1387 |
53836 | GPR87 | L1 | Human | Cervix | CC | 1.49e-05 | 4.36e-01 | 0.0802 |
53836 | GPR87 | T1 | Human | Cervix | CC | 3.50e-15 | 4.25e-01 | 0.0918 |
53836 | GPR87 | T3 | Human | Cervix | CC | 3.48e-25 | 5.29e-01 | 0.1389 |
53836 | GPR87 | LZE4T | Human | Esophagus | ESCC | 1.10e-20 | 6.21e-01 | 0.0811 |
53836 | GPR87 | LZE7T | Human | Esophagus | ESCC | 5.88e-03 | 9.37e-02 | 0.0667 |
53836 | GPR87 | LZE8T | Human | Esophagus | ESCC | 2.26e-08 | 4.20e-01 | 0.067 |
53836 | GPR87 | LZE20T | Human | Esophagus | ESCC | 1.87e-04 | 3.01e-01 | 0.0662 |
53836 | GPR87 | LZE24T | Human | Esophagus | ESCC | 5.87e-07 | 3.76e-01 | 0.0596 |
53836 | GPR87 | LZE21T | Human | Esophagus | ESCC | 1.93e-05 | 6.94e-01 | 0.0655 |
53836 | GPR87 | LZE6T | Human | Esophagus | ESCC | 7.40e-06 | 2.87e-01 | 0.0845 |
53836 | GPR87 | P1T-E | Human | Esophagus | ESCC | 1.93e-03 | 5.20e-01 | 0.0875 |
53836 | GPR87 | P2T-E | Human | Esophagus | ESCC | 3.07e-22 | 6.91e-01 | 0.1177 |
53836 | GPR87 | P4T-E | Human | Esophagus | ESCC | 5.35e-24 | 6.26e-01 | 0.1323 |
53836 | GPR87 | P5T-E | Human | Esophagus | ESCC | 6.93e-34 | 8.36e-01 | 0.1327 |
53836 | GPR87 | P8T-E | Human | Esophagus | ESCC | 1.49e-18 | 6.33e-01 | 0.0889 |
53836 | GPR87 | P9T-E | Human | Esophagus | ESCC | 1.12e-12 | 3.47e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR87 | SNV | Missense_Mutation | novel | c.37A>G | p.Asn13Asp | p.N13D | Q9BY21 | protein_coding | tolerated_low_confidence(0.78) | benign(0) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR87 | SNV | Missense_Mutation | rs765905861 | c.17N>T | p.Thr6Met | p.T6M | Q9BY21 | protein_coding | deleterious_low_confidence(0.02) | benign(0.178) | TCGA-G4-6626-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GPR87 | SNV | Missense_Mutation | c.1048N>T | p.Arg350Cys | p.R350C | Q9BY21 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
GPR87 | SNV | Missense_Mutation | rs747755482 | c.269N>C | p.Met90Thr | p.M90T | Q9BY21 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GPR87 | insertion | Frame_Shift_Ins | novel | c.871_872insA | p.Ile291AsnfsTer16 | p.I291Nfs*16 | Q9BY21 | protein_coding | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | ||
GPR87 | SNV | Missense_Mutation | novel | c.518N>A | p.Ser173Tyr | p.S173Y | Q9BY21 | protein_coding | deleterious(0) | possibly_damaging(0.671) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR87 | SNV | Missense_Mutation | c.572N>G | p.Asp191Gly | p.D191G | Q9BY21 | protein_coding | tolerated(0.08) | benign(0.078) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GPR87 | SNV | Missense_Mutation | c.683N>T | p.Ala228Val | p.A228V | Q9BY21 | protein_coding | tolerated(0.3) | benign(0.412) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPR87 | SNV | Missense_Mutation | c.1073N>C | p.Val358Ala | p.V358A | Q9BY21 | protein_coding | deleterious_low_confidence(0.01) | benign(0.108) | TCGA-B5-A11O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
GPR87 | SNV | Missense_Mutation | rs760390826 | c.452G>A | p.Arg151Gln | p.R151Q | Q9BY21 | protein_coding | tolerated(0.29) | possibly_damaging(0.656) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
53836 | GPR87 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135650457 | ||
53836 | GPR87 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135650190 | ||
53836 | GPR87 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651509 |
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