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Gene: GPANK1 |
Gene summary for GPANK1 |
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Gene information | Species | Human | Gene symbol | GPANK1 | Gene ID | 7918 |
Gene name | G-patch domain and ankyrin repeats 1 | |
Gene Alias | ANKRD59 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024RCU2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7918 | GPANK1 | LZE8T | Human | Esophagus | ESCC | 1.15e-03 | 8.45e-02 | 0.067 |
7918 | GPANK1 | LZE20T | Human | Esophagus | ESCC | 3.33e-03 | 1.70e-01 | 0.0662 |
7918 | GPANK1 | LZE24T | Human | Esophagus | ESCC | 1.08e-09 | 1.64e-01 | 0.0596 |
7918 | GPANK1 | LZE6T | Human | Esophagus | ESCC | 5.78e-07 | 2.63e-01 | 0.0845 |
7918 | GPANK1 | P1T-E | Human | Esophagus | ESCC | 3.42e-09 | 4.15e-01 | 0.0875 |
7918 | GPANK1 | P2T-E | Human | Esophagus | ESCC | 1.69e-26 | 5.18e-01 | 0.1177 |
7918 | GPANK1 | P4T-E | Human | Esophagus | ESCC | 1.21e-17 | 4.00e-01 | 0.1323 |
7918 | GPANK1 | P5T-E | Human | Esophagus | ESCC | 1.38e-17 | 3.03e-01 | 0.1327 |
7918 | GPANK1 | P8T-E | Human | Esophagus | ESCC | 1.27e-09 | 1.33e-01 | 0.0889 |
7918 | GPANK1 | P9T-E | Human | Esophagus | ESCC | 9.40e-11 | 2.54e-01 | 0.1131 |
7918 | GPANK1 | P10T-E | Human | Esophagus | ESCC | 7.99e-13 | 2.00e-01 | 0.116 |
7918 | GPANK1 | P11T-E | Human | Esophagus | ESCC | 3.41e-10 | 3.41e-01 | 0.1426 |
7918 | GPANK1 | P12T-E | Human | Esophagus | ESCC | 1.07e-16 | 3.00e-01 | 0.1122 |
7918 | GPANK1 | P15T-E | Human | Esophagus | ESCC | 1.97e-15 | 2.46e-01 | 0.1149 |
7918 | GPANK1 | P16T-E | Human | Esophagus | ESCC | 1.71e-18 | 3.10e-01 | 0.1153 |
7918 | GPANK1 | P17T-E | Human | Esophagus | ESCC | 7.49e-12 | 3.39e-01 | 0.1278 |
7918 | GPANK1 | P20T-E | Human | Esophagus | ESCC | 8.14e-08 | 2.08e-01 | 0.1124 |
7918 | GPANK1 | P21T-E | Human | Esophagus | ESCC | 1.14e-16 | 2.19e-01 | 0.1617 |
7918 | GPANK1 | P22T-E | Human | Esophagus | ESCC | 2.39e-23 | 3.27e-01 | 0.1236 |
7918 | GPANK1 | P23T-E | Human | Esophagus | ESCC | 2.45e-14 | 2.88e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPANK1 | SNV | Missense_Mutation | novel | c.611N>A | p.Arg204Lys | p.R204K | O95872 | protein_coding | tolerated(0.53) | benign(0.14) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPANK1 | SNV | Missense_Mutation | novel | c.207G>T | p.Lys69Asn | p.K69N | O95872 | protein_coding | deleterious(0.01) | benign(0.421) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPANK1 | SNV | Missense_Mutation | rs774998575 | c.47N>A | p.Ser16Asn | p.S16N | O95872 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
GPANK1 | SNV | Missense_Mutation | novel | c.303G>T | p.Glu101Asp | p.E101D | O95872 | protein_coding | tolerated(0.35) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
GPANK1 | SNV | Missense_Mutation | novel | c.412N>A | p.Ala138Thr | p.A138T | O95872 | protein_coding | tolerated(0.26) | benign(0.005) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPANK1 | SNV | Missense_Mutation | novel | c.807N>T | p.Glu269Asp | p.E269D | O95872 | protein_coding | tolerated(0.89) | benign(0.137) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPANK1 | SNV | Missense_Mutation | novel | c.412N>A | p.Ala138Thr | p.A138T | O95872 | protein_coding | tolerated(0.26) | benign(0.005) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPANK1 | SNV | Missense_Mutation | novel | c.497N>T | p.Gly166Val | p.G166V | O95872 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPANK1 | deletion | Frame_Shift_Del | novel | c.800delN | p.Gly267AlafsTer30 | p.G267Afs*30 | O95872 | protein_coding | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GPANK1 | SNV | Missense_Mutation | rs570286986 | c.493N>T | p.Arg165Cys | p.R165C | O95872 | protein_coding | tolerated(0.14) | probably_damaging(0.993) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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