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Gene: GNL3 |
Gene summary for GNL3 |
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Gene information | Species | Human | Gene symbol | GNL3 | Gene ID | 26354 |
Gene name | G protein nucleolar 3 | |
Gene Alias | C77032 | |
Cytomap | 3p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q9BVP2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26354 | GNL3 | LZE2T | Human | Esophagus | ESCC | 3.78e-07 | 4.39e-01 | 0.082 |
26354 | GNL3 | LZE4T | Human | Esophagus | ESCC | 5.67e-15 | 8.53e-02 | 0.0811 |
26354 | GNL3 | LZE5T | Human | Esophagus | ESCC | 1.33e-02 | 4.59e-01 | 0.0514 |
26354 | GNL3 | LZE7T | Human | Esophagus | ESCC | 3.20e-07 | 2.95e-01 | 0.0667 |
26354 | GNL3 | LZE8T | Human | Esophagus | ESCC | 1.80e-05 | 2.85e-02 | 0.067 |
26354 | GNL3 | LZE20T | Human | Esophagus | ESCC | 4.19e-04 | -1.41e-01 | 0.0662 |
26354 | GNL3 | LZE22D1 | Human | Esophagus | HGIN | 5.02e-04 | -6.46e-02 | 0.0595 |
26354 | GNL3 | LZE24T | Human | Esophagus | ESCC | 6.66e-11 | 5.55e-01 | 0.0596 |
26354 | GNL3 | LZE21T | Human | Esophagus | ESCC | 7.76e-06 | 6.98e-02 | 0.0655 |
26354 | GNL3 | LZE6T | Human | Esophagus | ESCC | 5.64e-05 | 1.76e-03 | 0.0845 |
26354 | GNL3 | P1T-E | Human | Esophagus | ESCC | 4.59e-08 | 7.05e-01 | 0.0875 |
26354 | GNL3 | P2T-E | Human | Esophagus | ESCC | 6.16e-17 | 2.59e-01 | 0.1177 |
26354 | GNL3 | P4T-E | Human | Esophagus | ESCC | 1.51e-20 | 6.73e-01 | 0.1323 |
26354 | GNL3 | P5T-E | Human | Esophagus | ESCC | 2.81e-14 | 2.74e-01 | 0.1327 |
26354 | GNL3 | P8T-E | Human | Esophagus | ESCC | 8.76e-11 | 2.99e-01 | 0.0889 |
26354 | GNL3 | P9T-E | Human | Esophagus | ESCC | 2.85e-19 | 5.53e-01 | 0.1131 |
26354 | GNL3 | P10T-E | Human | Esophagus | ESCC | 8.20e-35 | 5.18e-01 | 0.116 |
26354 | GNL3 | P11T-E | Human | Esophagus | ESCC | 7.38e-06 | 4.39e-01 | 0.1426 |
26354 | GNL3 | P12T-E | Human | Esophagus | ESCC | 5.36e-15 | 4.26e-01 | 0.1122 |
26354 | GNL3 | P15T-E | Human | Esophagus | ESCC | 3.25e-17 | 2.49e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:003164727 | Esophagus | HGIN | regulation of protein stability | 96/2587 | 298/18723 | 2.21e-16 | 5.76e-14 | 96 |
GO:190332027 | Esophagus | HGIN | regulation of protein modification by small protein conjugation or removal | 78/2587 | 242/18723 | 1.40e-13 | 2.26e-11 | 78 |
GO:003139627 | Esophagus | HGIN | regulation of protein ubiquitination | 64/2587 | 210/18723 | 3.02e-10 | 2.71e-08 | 64 |
GO:190382926 | Esophagus | HGIN | positive regulation of cellular protein localization | 75/2587 | 276/18723 | 3.19e-09 | 2.30e-07 | 75 |
GO:200125218 | Esophagus | HGIN | positive regulation of chromosome organization | 30/2587 | 82/18723 | 2.00e-07 | 9.68e-06 | 30 |
GO:190332127 | Esophagus | HGIN | negative regulation of protein modification by small protein conjugation or removal | 33/2587 | 95/18723 | 2.07e-07 | 9.95e-06 | 33 |
GO:003139727 | Esophagus | HGIN | negative regulation of protein ubiquitination | 30/2587 | 83/18723 | 2.72e-07 | 1.28e-05 | 30 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:003133425 | Esophagus | HGIN | positive regulation of protein-containing complex assembly | 61/2587 | 237/18723 | 7.10e-07 | 3.00e-05 | 61 |
GO:00330449 | Esophagus | HGIN | regulation of chromosome organization | 51/2587 | 187/18723 | 8.91e-07 | 3.61e-05 | 51 |
GO:00198277 | Esophagus | HGIN | stem cell population maintenance | 39/2587 | 131/18723 | 1.63e-06 | 6.14e-05 | 39 |
GO:004325427 | Esophagus | HGIN | regulation of protein-containing complex assembly | 94/2587 | 428/18723 | 2.39e-06 | 8.55e-05 | 94 |
GO:00987278 | Esophagus | HGIN | maintenance of cell number | 39/2587 | 134/18723 | 3.02e-06 | 1.03e-04 | 39 |
GO:001063920 | Esophagus | HGIN | negative regulation of organelle organization | 79/2587 | 348/18723 | 4.12e-06 | 1.37e-04 | 79 |
GO:000072318 | Esophagus | HGIN | telomere maintenance | 38/2587 | 131/18723 | 4.38e-06 | 1.42e-04 | 38 |
GO:003220416 | Esophagus | HGIN | regulation of telomere maintenance | 27/2587 | 80/18723 | 4.83e-06 | 1.56e-04 | 27 |
GO:003220617 | Esophagus | HGIN | positive regulation of telomere maintenance | 20/2587 | 52/18723 | 8.82e-06 | 2.64e-04 | 20 |
GO:005105214 | Esophagus | HGIN | regulation of DNA metabolic process | 79/2587 | 359/18723 | 1.38e-05 | 3.85e-04 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNL3 | SNV | Missense_Mutation | novel | c.1092N>G | p.Phe364Leu | p.F364L | Q9BVP2 | protein_coding | tolerated(0.08) | probably_damaging(0.914) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GNL3 | SNV | Missense_Mutation | novel | c.413N>G | p.Ile138Ser | p.I138S | Q9BVP2 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GNL3 | insertion | Frame_Shift_Ins | novel | c.64_65insA | p.Val25GlyfsTer13 | p.V25Gfs*13 | Q9BVP2 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GNL3 | SNV | Missense_Mutation | novel | c.1016N>T | p.Ala339Val | p.A339V | Q9BVP2 | protein_coding | deleterious(0.01) | benign(0.049) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GNL3 | SNV | Missense_Mutation | c.1106C>A | p.Ala369Asp | p.A369D | Q9BVP2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GNL3 | SNV | Missense_Mutation | c.968N>A | p.Arg323Gln | p.R323Q | Q9BVP2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GNL3 | SNV | Missense_Mutation | c.329N>G | p.Phe110Cys | p.F110C | Q9BVP2 | protein_coding | tolerated(0.2) | benign(0.375) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
GNL3 | SNV | Missense_Mutation | c.1220N>T | p.Thr407Ile | p.T407I | Q9BVP2 | protein_coding | tolerated(0.17) | benign(0.019) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GNL3 | SNV | Missense_Mutation | rs753758837 | c.1080N>A | p.Asn360Lys | p.N360K | Q9BVP2 | protein_coding | deleterious(0) | benign(0.071) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GNL3 | SNV | Missense_Mutation | novel | c.1133N>A | p.Gly378Asp | p.G378D | Q9BVP2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26354 | GNL3 | NA | cyclophosphamide | CYCLOPHOSPHAMIDE | ||
26354 | GNL3 | NA | epirubicin | EPIRUBICIN | ||
26354 | GNL3 | NA | fluorouracil | FLUOROURACIL |
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