![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GLB1L |
Gene summary for GLB1L |
![]() |
Gene information | Species | Human | Gene symbol | GLB1L | Gene ID | 79411 |
Gene name | galactosidase beta 1 like | |
Gene Alias | GLB1L | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A140VJK0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79411 | GLB1L | HCC1_Meng | Human | Liver | HCC | 3.95e-07 | 1.01e-02 | 0.0246 |
79411 | GLB1L | HCC1 | Human | Liver | HCC | 1.74e-03 | 1.68e+00 | 0.5336 |
79411 | GLB1L | HCC2 | Human | Liver | HCC | 1.52e-06 | 2.13e+00 | 0.5341 |
79411 | GLB1L | HCC5 | Human | Liver | HCC | 1.08e-02 | 2.87e-01 | 0.4932 |
79411 | GLB1L | S016 | Human | Liver | HCC | 5.71e-03 | 1.52e-01 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLB1L | SNV | Missense_Mutation | c.781N>A | p.Val261Ile | p.V261I | Q6UWU2 | protein_coding | tolerated(0.13) | probably_damaging(0.923) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GLB1L | SNV | Missense_Mutation | novel | c.1663N>A | p.Phe555Ile | p.F555I | Q6UWU2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GLB1L | SNV | Missense_Mutation | novel | c.1539N>C | p.Lys513Asn | p.K513N | Q6UWU2 | protein_coding | tolerated(0.57) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GLB1L | SNV | Missense_Mutation | novel | c.1769N>T | p.Arg590Ile | p.R590I | Q6UWU2 | protein_coding | tolerated(0.12) | benign(0.418) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GLB1L | SNV | Missense_Mutation | rs763648085 | c.857N>T | p.Thr286Ile | p.T286I | Q6UWU2 | protein_coding | deleterious(0.04) | benign(0.012) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GLB1L | SNV | Missense_Mutation | novel | c.919G>A | p.Gly307Ser | p.G307S | Q6UWU2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GLB1L | SNV | Missense_Mutation | c.1937N>A | p.Ser646Tyr | p.S646Y | Q6UWU2 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
GLB1L | SNV | Missense_Mutation | novel | c.616N>T | p.Arg206Cys | p.R206C | Q6UWU2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GLB1L | SNV | Missense_Mutation | novel | c.1604N>A | p.Pro535His | p.P535H | Q6UWU2 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GLB1L | SNV | Missense_Mutation | c.825N>T | p.Gln275His | p.Q275H | Q6UWU2 | protein_coding | tolerated(0.27) | benign(0.009) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |