GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004343412 | Liver | Cirrhotic | response to peptide hormone | 149/4634 | 414/18723 | 1.70e-07 | 4.49e-06 | 149 |
GO:007137511 | Liver | Cirrhotic | cellular response to peptide hormone stimulus | 110/4634 | 290/18723 | 3.73e-07 | 8.82e-06 | 110 |
GO:190165311 | Liver | Cirrhotic | cellular response to peptide | 129/4634 | 359/18723 | 1.23e-06 | 2.49e-05 | 129 |
GO:003286911 | Liver | Cirrhotic | cellular response to insulin stimulus | 80/4634 | 203/18723 | 2.55e-06 | 4.63e-05 | 80 |
GO:003286811 | Liver | Cirrhotic | response to insulin | 95/4634 | 264/18723 | 2.77e-05 | 3.54e-04 | 95 |
GO:19000782 | Liver | Cirrhotic | positive regulation of cellular response to insulin stimulus | 15/4634 | 25/18723 | 1.88e-04 | 1.75e-03 | 15 |
GO:000828611 | Liver | Cirrhotic | insulin receptor signaling pathway | 44/4634 | 116/18723 | 1.09e-03 | 7.59e-03 | 44 |
GO:0046628 | Liver | Cirrhotic | positive regulation of insulin receptor signaling pathway | 12/4634 | 22/18723 | 2.61e-03 | 1.53e-02 | 12 |
GO:19000761 | Liver | Cirrhotic | regulation of cellular response to insulin stimulus | 26/4634 | 64/18723 | 3.69e-03 | 2.03e-02 | 26 |
GO:003286821 | Liver | HCC | response to insulin | 172/7958 | 264/18723 | 7.14e-14 | 4.23e-12 | 172 |
GO:003286921 | Liver | HCC | cellular response to insulin stimulus | 137/7958 | 203/18723 | 4.69e-13 | 2.44e-11 | 137 |
GO:004343422 | Liver | HCC | response to peptide hormone | 247/7958 | 414/18723 | 9.55e-13 | 4.77e-11 | 247 |
GO:007137521 | Liver | HCC | cellular response to peptide hormone stimulus | 179/7958 | 290/18723 | 2.54e-11 | 9.88e-10 | 179 |
GO:190165321 | Liver | HCC | cellular response to peptide | 211/7958 | 359/18723 | 2.86e-10 | 9.63e-09 | 211 |
GO:00082862 | Liver | HCC | insulin receptor signaling pathway | 78/7958 | 116/18723 | 6.15e-08 | 1.29e-06 | 78 |
GO:19000762 | Liver | HCC | regulation of cellular response to insulin stimulus | 43/7958 | 64/18723 | 5.73e-05 | 5.31e-04 | 43 |
GO:190007811 | Liver | HCC | positive regulation of cellular response to insulin stimulus | 20/7958 | 25/18723 | 1.47e-04 | 1.18e-03 | 20 |
GO:00466261 | Liver | HCC | regulation of insulin receptor signaling pathway | 43/7958 | 66/18723 | 1.69e-04 | 1.34e-03 | 43 |
GO:00466281 | Liver | HCC | positive regulation of insulin receptor signaling pathway | 17/7958 | 22/18723 | 9.84e-04 | 5.70e-03 | 17 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GKAP1 | SNV | Missense_Mutation | novel | c.106N>T | p.Gly36Cys | p.G36C | Q5VSY0 | protein_coding | deleterious(0.01) | possibly_damaging(0.859) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GKAP1 | SNV | Missense_Mutation | novel | c.159G>T | p.Glu53Asp | p.E53D | Q5VSY0 | protein_coding | tolerated(0.25) | benign(0.009) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
GKAP1 | SNV | Missense_Mutation | novel | c.1073N>T | p.Arg358Ile | p.R358I | Q5VSY0 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
GKAP1 | SNV | Missense_Mutation | novel | c.448N>T | p.Asp150Tyr | p.D150Y | Q5VSY0 | protein_coding | deleterious(0.01) | benign(0.051) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
GKAP1 | SNV | Missense_Mutation | | c.915N>T | p.Lys305Asn | p.K305N | Q5VSY0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GKAP1 | SNV | Missense_Mutation | rs755540642 | c.761G>T | p.Arg254Ile | p.R254I | Q5VSY0 | protein_coding | deleterious(0) | possibly_damaging(0.784) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GKAP1 | SNV | Missense_Mutation | | c.967N>G | p.Thr323Ala | p.T323A | Q5VSY0 | protein_coding | deleterious(0) | possibly_damaging(0.672) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
GKAP1 | SNV | Missense_Mutation | novel | c.105N>C | p.Lys35Asn | p.K35N | Q5VSY0 | protein_coding | tolerated(0.08) | benign(0.284) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
GKAP1 | SNV | Missense_Mutation | | c.940N>A | p.Glu314Lys | p.E314K | Q5VSY0 | protein_coding | tolerated(0.1) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GKAP1 | SNV | Missense_Mutation | novel | c.646G>T | p.Asp216Tyr | p.D216Y | Q5VSY0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |