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Gene: GGA2 |
Gene summary for GGA2 |
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Gene information | Species | Human | Gene symbol | GGA2 | Gene ID | 23062 |
Gene name | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | |
Gene Alias | VEAR | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9UJY4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23062 | GGA2 | LZE4T | Human | Esophagus | ESCC | 1.34e-06 | 1.65e-01 | 0.0811 |
23062 | GGA2 | LZE7T | Human | Esophagus | ESCC | 5.35e-05 | 3.00e-01 | 0.0667 |
23062 | GGA2 | LZE21D1 | Human | Esophagus | HGIN | 4.55e-03 | 3.10e-01 | 0.0632 |
23062 | GGA2 | LZE24T | Human | Esophagus | ESCC | 5.04e-04 | 1.51e-01 | 0.0596 |
23062 | GGA2 | LZE21T | Human | Esophagus | ESCC | 3.57e-02 | 1.62e-01 | 0.0655 |
23062 | GGA2 | P1T-E | Human | Esophagus | ESCC | 2.97e-04 | 3.80e-01 | 0.0875 |
23062 | GGA2 | P2T-E | Human | Esophagus | ESCC | 6.98e-27 | 5.48e-01 | 0.1177 |
23062 | GGA2 | P4T-E | Human | Esophagus | ESCC | 3.06e-09 | 2.54e-01 | 0.1323 |
23062 | GGA2 | P5T-E | Human | Esophagus | ESCC | 1.07e-08 | 1.52e-01 | 0.1327 |
23062 | GGA2 | P8T-E | Human | Esophagus | ESCC | 1.04e-14 | 2.62e-01 | 0.0889 |
23062 | GGA2 | P9T-E | Human | Esophagus | ESCC | 4.76e-16 | 1.87e-01 | 0.1131 |
23062 | GGA2 | P10T-E | Human | Esophagus | ESCC | 9.57e-12 | 2.77e-01 | 0.116 |
23062 | GGA2 | P11T-E | Human | Esophagus | ESCC | 1.01e-08 | 3.51e-01 | 0.1426 |
23062 | GGA2 | P12T-E | Human | Esophagus | ESCC | 7.74e-22 | 5.09e-01 | 0.1122 |
23062 | GGA2 | P15T-E | Human | Esophagus | ESCC | 3.59e-18 | 3.70e-01 | 0.1149 |
23062 | GGA2 | P16T-E | Human | Esophagus | ESCC | 2.31e-15 | 3.05e-01 | 0.1153 |
23062 | GGA2 | P17T-E | Human | Esophagus | ESCC | 1.08e-04 | 1.54e-01 | 0.1278 |
23062 | GGA2 | P20T-E | Human | Esophagus | ESCC | 1.56e-10 | 2.48e-01 | 0.1124 |
23062 | GGA2 | P21T-E | Human | Esophagus | ESCC | 3.79e-11 | 2.24e-01 | 0.1617 |
23062 | GGA2 | P22T-E | Human | Esophagus | ESCC | 1.22e-19 | 2.92e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819317 | Esophagus | HGIN | Golgi vesicle transport | 83/2587 | 296/18723 | 8.59e-11 | 8.89e-09 | 83 |
GO:009015020 | Esophagus | HGIN | establishment of protein localization to membrane | 67/2587 | 260/18723 | 1.96e-07 | 9.57e-06 | 67 |
GO:007265920 | Esophagus | HGIN | protein localization to plasma membrane | 66/2587 | 284/18723 | 1.11e-05 | 3.18e-04 | 66 |
GO:009887610 | Esophagus | HGIN | vesicle-mediated transport to the plasma membrane | 36/2587 | 136/18723 | 6.76e-05 | 1.55e-03 | 36 |
GO:199077818 | Esophagus | HGIN | protein localization to cell periphery | 71/2587 | 333/18723 | 1.05e-04 | 2.24e-03 | 71 |
GO:000689210 | Esophagus | HGIN | post-Golgi vesicle-mediated transport | 26/2587 | 104/18723 | 1.63e-03 | 1.81e-02 | 26 |
GO:00430019 | Esophagus | HGIN | Golgi to plasma membrane protein transport | 13/2587 | 40/18723 | 2.04e-03 | 2.13e-02 | 13 |
GO:00068939 | Esophagus | HGIN | Golgi to plasma membrane transport | 17/2587 | 60/18723 | 2.46e-03 | 2.45e-02 | 17 |
GO:00619519 | Esophagus | HGIN | establishment of protein localization to plasma membrane | 17/2587 | 60/18723 | 2.46e-03 | 2.45e-02 | 17 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:000689215 | Esophagus | ESCC | post-Golgi vesicle-mediated transport | 82/8552 | 104/18723 | 4.00e-12 | 1.55e-10 | 82 |
GO:009887615 | Esophagus | ESCC | vesicle-mediated transport to the plasma membrane | 99/8552 | 136/18723 | 1.13e-10 | 3.39e-09 | 99 |
GO:000689315 | Esophagus | ESCC | Golgi to plasma membrane transport | 48/8552 | 60/18723 | 5.11e-08 | 9.16e-07 | 48 |
GO:004300114 | Esophagus | ESCC | Golgi to plasma membrane protein transport | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
GO:006195114 | Esophagus | ESCC | establishment of protein localization to plasma membrane | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:009015018 | Oral cavity | OSCC | establishment of protein localization to membrane | 163/7305 | 260/18723 | 7.13e-15 | 4.47e-13 | 163 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041426 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414213 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414221 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0414231 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GGA2 | SNV | Missense_Mutation | rs146363257 | c.881N>T | p.Ala294Val | p.A294V | Q9UJY4 | protein_coding | deleterious(0.04) | probably_damaging(0.986) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GGA2 | SNV | Missense_Mutation | rs760553146 | c.1487G>T | p.Gly496Val | p.G496V | Q9UJY4 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GGA2 | SNV | Missense_Mutation | c.674N>T | p.Ser225Leu | p.S225L | Q9UJY4 | protein_coding | tolerated(0.3) | possibly_damaging(0.854) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GGA2 | SNV | Missense_Mutation | novel | c.1096N>T | p.Pro366Ser | p.P366S | Q9UJY4 | protein_coding | tolerated(0.43) | benign(0.013) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GGA2 | SNV | Missense_Mutation | rs764416125 | c.757N>T | p.Arg253Cys | p.R253C | Q9UJY4 | protein_coding | deleterious(0.02) | benign(0.118) | TCGA-AJ-A3NH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
GGA2 | SNV | Missense_Mutation | c.1157T>C | p.Met386Thr | p.M386T | Q9UJY4 | protein_coding | tolerated(0.66) | benign(0) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GGA2 | SNV | Missense_Mutation | c.674N>T | p.Ser225Leu | p.S225L | Q9UJY4 | protein_coding | tolerated(0.3) | possibly_damaging(0.854) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GGA2 | SNV | Missense_Mutation | c.575N>A | p.Ser192Tyr | p.S192Y | Q9UJY4 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
GGA2 | SNV | Missense_Mutation | c.1072N>G | p.Pro358Ala | p.P358A | Q9UJY4 | protein_coding | tolerated(0.11) | benign(0.006) | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD | |
GGA2 | SNV | Missense_Mutation | novel | c.1609N>A | p.Ala537Thr | p.A537T | Q9UJY4 | protein_coding | tolerated(0.05) | probably_damaging(0.992) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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