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Gene: GANAB |
Gene summary for GANAB |
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Gene information | Species | Human | Gene symbol | GANAB | Gene ID | 23193 |
Gene name | glucosidase II alpha subunit | |
Gene Alias | G2AN | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | B4DZ53 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23193 | GANAB | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.39e-16 | 4.70e-01 | 0.0155 |
23193 | GANAB | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.00e-24 | 7.78e-01 | -0.1808 |
23193 | GANAB | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.35e-07 | 7.20e-01 | 0.0216 |
23193 | GANAB | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.64e-13 | 7.89e-01 | -0.0811 |
23193 | GANAB | HTA11_78_2000001011 | Human | Colorectum | AD | 3.47e-08 | 4.60e-01 | -0.1088 |
23193 | GANAB | HTA11_347_2000001011 | Human | Colorectum | AD | 2.53e-38 | 9.22e-01 | -0.1954 |
23193 | GANAB | HTA11_411_2000001011 | Human | Colorectum | SER | 1.47e-08 | 8.77e-01 | -0.2602 |
23193 | GANAB | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.52e-04 | 8.09e-01 | -0.2196 |
23193 | GANAB | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.54e-09 | 6.32e-01 | -0.1207 |
23193 | GANAB | HTA11_83_2000001011 | Human | Colorectum | SER | 7.79e-18 | 7.85e-01 | -0.1526 |
23193 | GANAB | HTA11_696_2000001011 | Human | Colorectum | AD | 1.16e-36 | 9.63e-01 | -0.1464 |
23193 | GANAB | HTA11_866_2000001011 | Human | Colorectum | AD | 1.00e-15 | 5.94e-01 | -0.1001 |
23193 | GANAB | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.04e-36 | 1.18e+00 | -0.059 |
23193 | GANAB | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.11e-05 | 6.88e-01 | -0.1706 |
23193 | GANAB | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.39e-03 | 4.11e-01 | -0.2061 |
23193 | GANAB | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.44e-04 | 6.64e-01 | -0.1462 |
23193 | GANAB | HTA11_546_2000001011 | Human | Colorectum | AD | 5.12e-14 | 7.45e-01 | -0.0842 |
23193 | GANAB | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.50e-02 | 7.12e-01 | -0.00410000000000005 |
23193 | GANAB | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.37e-11 | 7.43e-01 | -0.0179 |
23193 | GANAB | HTA11_866_3004761011 | Human | Colorectum | AD | 3.66e-44 | 1.07e+00 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091003 | Thyroid | PTC | glycoprotein metabolic process | 147/5968 | 387/18723 | 5.87e-03 | 2.64e-02 | 147 |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa00510 | Colorectum | AD | N-Glycan biosynthesis | 21/2092 | 53/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 21 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa005101 | Colorectum | AD | N-Glycan biosynthesis | 21/2092 | 53/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 21 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa005102 | Colorectum | MSS | N-Glycan biosynthesis | 20/1875 | 53/8465 | 7.17e-03 | 2.83e-02 | 1.73e-02 | 20 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa005103 | Colorectum | MSS | N-Glycan biosynthesis | 20/1875 | 53/8465 | 7.17e-03 | 2.83e-02 | 1.73e-02 | 20 |
hsa041418 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa041419 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0051023 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0051033 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa005104 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0051011 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GANAB | SNV | Missense_Mutation | novel | c.2479C>T | p.Arg827Cys | p.R827C | Q14697 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GANAB | SNV | Missense_Mutation | novel | c.2663C>T | p.Ser888Leu | p.S888L | Q14697 | protein_coding | tolerated(0.16) | benign(0.007) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GANAB | SNV | Missense_Mutation | c.767N>T | p.Ser256Phe | p.S256F | Q14697 | protein_coding | tolerated(0.27) | benign(0.213) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GANAB | SNV | Missense_Mutation | rs377690186 | c.1430N>A | p.Arg477His | p.R477H | Q14697 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-FU-A2QG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GANAB | SNV | Missense_Mutation | novel | c.2629C>G | p.Gln877Glu | p.Q877E | Q14697 | protein_coding | tolerated(1) | benign(0) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GANAB | SNV | Missense_Mutation | novel | c.1093N>A | p.Gln365Lys | p.Q365K | Q14697 | protein_coding | tolerated(0.87) | benign(0.018) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GANAB | SNV | Missense_Mutation | novel | c.765N>G | p.His255Gln | p.H255Q | Q14697 | protein_coding | tolerated(0.06) | possibly_damaging(0.511) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GANAB | SNV | Missense_Mutation | c.2086N>T | p.Arg696Trp | p.R696W | Q14697 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
GANAB | SNV | Missense_Mutation | rs371161821 | c.2872N>A | p.Ala958Thr | p.A958T | Q14697 | protein_coding | deleterious(0.04) | benign(0.025) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GANAB | SNV | Missense_Mutation | c.205N>G | p.Leu69Val | p.L69V | Q14697 | protein_coding | tolerated(0.17) | benign(0.155) | TCGA-AA-3846-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23193 | GANAB | DRUGGABLE GENOME, ENZYME | MIGLUSTAT | MIGLUSTAT | 21292481 |
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