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Gene: GALNT15 |
Gene summary for GALNT15 |
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Gene information | Species | Human | Gene symbol | GALNT15 | Gene ID | 117248 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 15 | |
Gene Alias | GALNACT15 | |
Cytomap | 3p25.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | C9JGI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
117248 | GALNT15 | HCC1 | Human | Liver | HCC | 1.17e-09 | 7.53e-01 | 0.5336 |
117248 | GALNT15 | HCC2 | Human | Liver | HCC | 3.58e-20 | 1.25e+00 | 0.5341 |
117248 | GALNT15 | HCC5 | Human | Liver | HCC | 4.92e-25 | 1.30e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064862 | Liver | HCC | protein glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00434132 | Liver | HCC | macromolecule glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00700852 | Liver | HCC | glycosylation | 128/7958 | 240/18723 | 4.35e-04 | 2.92e-03 | 128 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GALNT15 | SNV | Missense_Mutation | c.656C>A | p.Pro219His | p.P219H | Q8N3T1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GALNT15 | SNV | Missense_Mutation | novel | c.1436N>T | p.Arg479Ile | p.R479I | Q8N3T1 | protein_coding | deleterious(0) | possibly_damaging(0.499) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GALNT15 | SNV | Missense_Mutation | c.625C>T | p.Arg209Trp | p.R209W | Q8N3T1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GALNT15 | SNV | Missense_Mutation | rs866703781 | c.178N>A | p.Asp60Asn | p.D60N | Q8N3T1 | protein_coding | tolerated_low_confidence(0.16) | benign(0.001) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GALNT15 | SNV | Missense_Mutation | rs191977190 | c.1315N>T | p.Arg439Cys | p.R439C | Q8N3T1 | protein_coding | deleterious(0.01) | possibly_damaging(0.886) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GALNT15 | SNV | Missense_Mutation | novel | c.1293N>T | p.Glu431Asp | p.E431D | Q8N3T1 | protein_coding | tolerated(0.16) | benign(0.056) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GALNT15 | SNV | Missense_Mutation | novel | c.485N>T | p.Ala162Val | p.A162V | Q8N3T1 | protein_coding | tolerated(0.51) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GALNT15 | SNV | Missense_Mutation | c.1153N>A | p.Leu385Ile | p.L385I | Q8N3T1 | protein_coding | tolerated(0.19) | benign(0.041) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GALNT15 | SNV | Missense_Mutation | c.1500N>T | p.Glu500Asp | p.E500D | Q8N3T1 | protein_coding | deleterious(0.03) | benign(0.006) | TCGA-A5-A0R7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GALNT15 | SNV | Missense_Mutation | rs535247367 | c.1183N>A | p.Glu395Lys | p.E395K | Q8N3T1 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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