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Gene: FYB |
Gene summary for FYB |
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Gene information | Species | Human | Gene symbol | FYB | Gene ID | 2533 |
Gene name | FYN binding protein 1 | |
Gene Alias | ADAP | |
Cytomap | 5p13.1 | |
Gene Type | protein-coding | GO ID | GO:0002253 | UniProtAcc | O15117 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2533 | FYB | P8T-E | Human | Esophagus | ESCC | 7.07e-03 | 1.29e-01 | 0.0889 |
2533 | FYB | P11T-E | Human | Esophagus | ESCC | 5.85e-07 | 5.91e-01 | 0.1426 |
2533 | FYB | P17T-E | Human | Esophagus | ESCC | 7.99e-07 | 5.69e-01 | 0.1278 |
2533 | FYB | P22T-E | Human | Esophagus | ESCC | 8.86e-04 | 1.33e-01 | 0.1236 |
2533 | FYB | P24T-E | Human | Esophagus | ESCC | 1.25e-18 | 6.76e-01 | 0.1287 |
2533 | FYB | P47T-E | Human | Esophagus | ESCC | 1.50e-19 | 7.33e-01 | 0.1067 |
2533 | FYB | P52T-E | Human | Esophagus | ESCC | 3.00e-11 | 3.31e-01 | 0.1555 |
2533 | FYB | P54T-E | Human | Esophagus | ESCC | 1.15e-16 | 7.56e-01 | 0.0975 |
2533 | FYB | P62T-E | Human | Esophagus | ESCC | 2.40e-04 | 5.33e-01 | 0.1302 |
2533 | FYB | P75T-E | Human | Esophagus | ESCC | 3.14e-23 | 7.24e-01 | 0.1125 |
2533 | FYB | P128T-E | Human | Esophagus | ESCC | 3.21e-17 | 7.27e-01 | 0.1241 |
2533 | FYB | HCC1_Meng | Human | Liver | HCC | 4.35e-06 | -1.57e-02 | 0.0246 |
2533 | FYB | HCC2 | Human | Liver | HCC | 2.06e-07 | 1.07e+00 | 0.5341 |
2533 | FYB | HCC5 | Human | Liver | HCC | 3.49e-30 | 2.73e+00 | 0.4932 |
2533 | FYB | Pt13.a | Human | Liver | HCC | 1.20e-07 | 2.83e-01 | 0.021 |
2533 | FYB | Pt13.b | Human | Liver | HCC | 4.50e-02 | 1.18e-02 | 0.0251 |
2533 | FYB | Pt13.c | Human | Liver | HCC | 4.43e-05 | 4.69e-01 | 0.0076 |
2533 | FYB | Pt14.d | Human | Liver | HCC | 9.44e-22 | 5.20e-01 | 0.0143 |
2533 | FYB | C04 | Human | Oral cavity | OSCC | 5.42e-13 | 5.94e-01 | 0.2633 |
2533 | FYB | C21 | Human | Oral cavity | OSCC | 1.96e-38 | 1.22e+00 | 0.2678 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00072295 | Cervix | CC | integrin-mediated signaling pathway | 34/2311 | 107/18723 | 1.01e-07 | 5.25e-06 | 34 |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:00022533 | Cervix | CC | activation of immune response | 72/2311 | 375/18723 | 8.26e-05 | 1.11e-03 | 72 |
GO:0002768 | Cervix | CC | immune response-regulating cell surface receptor signaling pathway | 59/2311 | 315/18723 | 6.64e-04 | 6.11e-03 | 59 |
GO:00508524 | Cervix | CC | T cell receptor signaling pathway | 27/2311 | 123/18723 | 1.93e-03 | 1.42e-02 | 27 |
GO:000225312 | Cervix | HSIL_HPV | activation of immune response | 40/737 | 375/18723 | 1.12e-08 | 1.30e-06 | 40 |
GO:000276411 | Cervix | HSIL_HPV | immune response-regulating signaling pathway | 46/737 | 468/18723 | 1.17e-08 | 1.30e-06 | 46 |
GO:000722913 | Cervix | HSIL_HPV | integrin-mediated signaling pathway | 19/737 | 107/18723 | 3.37e-08 | 2.76e-06 | 19 |
GO:00027681 | Cervix | HSIL_HPV | immune response-regulating cell surface receptor signaling pathway | 32/737 | 315/18723 | 9.80e-07 | 4.68e-05 | 32 |
GO:0002429 | Cervix | HSIL_HPV | immune response-activating cell surface receptor signaling pathway | 28/737 | 291/18723 | 1.29e-05 | 4.09e-04 | 28 |
GO:0002757 | Cervix | HSIL_HPV | immune response-activating signal transduction | 28/737 | 291/18723 | 1.29e-05 | 4.09e-04 | 28 |
GO:00508513 | Cervix | HSIL_HPV | antigen receptor-mediated signaling pathway | 22/737 | 240/18723 | 2.15e-04 | 3.83e-03 | 22 |
GO:005085211 | Cervix | HSIL_HPV | T cell receptor signaling pathway | 13/737 | 123/18723 | 1.12e-03 | 1.36e-02 | 13 |
GO:007265913 | Cervix | HSIL_HPV | protein localization to plasma membrane | 21/737 | 284/18723 | 4.36e-03 | 3.68e-02 | 21 |
GO:007265914 | Endometrium | AEH | protein localization to plasma membrane | 63/2100 | 284/18723 | 7.58e-08 | 3.92e-06 | 63 |
GO:00072296 | Endometrium | AEH | integrin-mediated signaling pathway | 32/2100 | 107/18723 | 1.24e-07 | 5.80e-06 | 32 |
GO:19907789 | Endometrium | AEH | protein localization to cell periphery | 68/2100 | 333/18723 | 6.38e-07 | 2.38e-05 | 68 |
GO:00027645 | Endometrium | AEH | immune response-regulating signaling pathway | 76/2100 | 468/18723 | 5.76e-04 | 5.71e-03 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0513516 | Cervix | CC | Yersinia infection | 39/1267 | 137/8465 | 3.27e-05 | 2.41e-04 | 1.42e-04 | 39 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0513517 | Cervix | CC | Yersinia infection | 39/1267 | 137/8465 | 3.27e-05 | 2.41e-04 | 1.42e-04 | 39 |
hsa0513526 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa05135111 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FYB | SNV | Missense_Mutation | c.1989N>C | p.Leu663Phe | p.L663F | O15117 | protein_coding | deleterious(0.01) | possibly_damaging(0.826) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FYB | SNV | Missense_Mutation | novel | c.1873N>G | p.Ile625Val | p.I625V | O15117 | protein_coding | tolerated(0.29) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FYB | deletion | Frame_Shift_Del | c.1002delG | p.Pro335HisfsTer44 | p.P335Hfs*44 | O15117 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
FYB | SNV | Missense_Mutation | novel | c.341N>G | p.Glu114Gly | p.E114G | O15117 | protein_coding | tolerated(0.21) | possibly_damaging(0.563) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FYB | SNV | Missense_Mutation | c.1130N>G | p.Asp377Gly | p.D377G | O15117 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FYB | SNV | Missense_Mutation | c.2211C>A | p.Asp737Glu | p.D737E | O15117 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FYB | SNV | Missense_Mutation | rs757886197 | c.536C>T | p.Ala179Val | p.A179V | O15117 | protein_coding | tolerated(0.87) | benign(0) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FYB | SNV | Missense_Mutation | c.1608G>T | p.Lys536Asn | p.K536N | O15117 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FYB | SNV | Missense_Mutation | rs760474346 | c.667G>A | p.Glu223Lys | p.E223K | O15117 | protein_coding | deleterious(0.02) | benign(0.202) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FYB | SNV | Missense_Mutation | c.1420N>T | p.Asp474Tyr | p.D474Y | O15117 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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