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Gene: FRRS1L |
Gene summary for FRRS1L |
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Gene information | Species | Human | Gene symbol | FRRS1L | Gene ID | 23732 |
Gene name | ferric chelate reductase 1 like | |
Gene Alias | C9orf4 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9P0K9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23732 | FRRS1L | HCC1 | Human | Liver | HCC | 3.61e-11 | 2.01e+00 | 0.5336 |
23732 | FRRS1L | HCC2 | Human | Liver | HCC | 1.53e-24 | 2.03e+00 | 0.5341 |
23732 | FRRS1L | HCC5 | Human | Liver | HCC | 5.58e-11 | 1.14e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FRRS1L | SNV | Missense_Mutation | novel | c.988N>T | p.Leu330Phe | p.L330F | Q9P0K9 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
FRRS1L | SNV | Missense_Mutation | novel | c.672N>T | p.Gln224His | p.Q224H | Q9P0K9 | protein_coding | tolerated(0.16) | benign(0.011) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
FRRS1L | SNV | Missense_Mutation | c.776N>A | p.Arg259His | p.R259H | Q9P0K9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FRRS1L | SNV | Missense_Mutation | novel | c.846N>T | p.Trp282Cys | p.W282C | Q9P0K9 | protein_coding | tolerated(0.13) | probably_damaging(0.999) | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FRRS1L | SNV | Missense_Mutation | c.991N>A | p.Leu331Met | p.L331M | Q9P0K9 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
FRRS1L | SNV | Missense_Mutation | c.875N>A | p.Arg292Gln | p.R292Q | Q9P0K9 | protein_coding | tolerated(0.1) | probably_damaging(0.978) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FRRS1L | SNV | Missense_Mutation | c.597N>A | p.Phe199Leu | p.F199L | Q9P0K9 | protein_coding | tolerated(0.29) | probably_damaging(0.987) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FRRS1L | SNV | Missense_Mutation | c.1020N>T | p.Leu340Phe | p.L340F | Q9P0K9 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.994) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FRRS1L | SNV | Missense_Mutation | c.597N>A | p.Phe199Leu | p.F199L | Q9P0K9 | protein_coding | tolerated(0.29) | probably_damaging(0.987) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
FRRS1L | SNV | Missense_Mutation | novel | c.455G>A | p.Gly152Glu | p.G152E | Q9P0K9 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-L9-A443-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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