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Gene: FOXC1 |
Gene summary for FOXC1 |
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Gene information | Species | Human | Gene symbol | FOXC1 | Gene ID | 2296 |
Gene name | forkhead box C1 | |
Gene Alias | ARA | |
Cytomap | 6p25.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q12948 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2296 | FOXC1 | LZE4T | Human | Esophagus | ESCC | 1.93e-02 | -3.22e-01 | 0.0811 |
2296 | FOXC1 | LZE8T | Human | Esophagus | ESCC | 7.51e-06 | -2.23e-01 | 0.067 |
2296 | FOXC1 | LZE20T | Human | Esophagus | ESCC | 6.68e-08 | -7.44e-02 | 0.0662 |
2296 | FOXC1 | LZE24T | Human | Esophagus | ESCC | 6.33e-05 | -3.17e-01 | 0.0596 |
2296 | FOXC1 | LZE21T | Human | Esophagus | ESCC | 2.11e-02 | -1.98e-01 | 0.0655 |
2296 | FOXC1 | P2T-E | Human | Esophagus | ESCC | 4.32e-20 | 5.70e-01 | 0.1177 |
2296 | FOXC1 | P4T-E | Human | Esophagus | ESCC | 3.02e-06 | -2.68e-01 | 0.1323 |
2296 | FOXC1 | P5T-E | Human | Esophagus | ESCC | 9.23e-06 | -3.24e-01 | 0.1327 |
2296 | FOXC1 | P8T-E | Human | Esophagus | ESCC | 4.94e-08 | -1.79e-01 | 0.0889 |
2296 | FOXC1 | P9T-E | Human | Esophagus | ESCC | 2.28e-05 | -2.83e-01 | 0.1131 |
2296 | FOXC1 | P10T-E | Human | Esophagus | ESCC | 3.31e-07 | -2.93e-01 | 0.116 |
2296 | FOXC1 | P11T-E | Human | Esophagus | ESCC | 8.05e-09 | 1.34e-01 | 0.1426 |
2296 | FOXC1 | P12T-E | Human | Esophagus | ESCC | 3.77e-06 | -1.72e-01 | 0.1122 |
2296 | FOXC1 | P15T-E | Human | Esophagus | ESCC | 1.14e-04 | -3.18e-01 | 0.1149 |
2296 | FOXC1 | P16T-E | Human | Esophagus | ESCC | 2.63e-17 | 1.30e-01 | 0.1153 |
2296 | FOXC1 | P17T-E | Human | Esophagus | ESCC | 1.51e-03 | -4.14e-02 | 0.1278 |
2296 | FOXC1 | P20T-E | Human | Esophagus | ESCC | 1.57e-04 | -3.08e-01 | 0.1124 |
2296 | FOXC1 | P21T-E | Human | Esophagus | ESCC | 4.23e-07 | -2.55e-01 | 0.1617 |
2296 | FOXC1 | P22T-E | Human | Esophagus | ESCC | 1.14e-07 | -2.67e-01 | 0.1236 |
2296 | FOXC1 | P23T-E | Human | Esophagus | ESCC | 2.40e-05 | -7.24e-02 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:0051099111 | Esophagus | ESCC | positive regulation of binding | 122/8552 | 173/18723 | 2.79e-11 | 9.45e-10 | 122 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:0051101111 | Esophagus | ESCC | regulation of DNA binding | 84/8552 | 118/18723 | 1.64e-08 | 3.21e-07 | 84 |
GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:004593013 | Esophagus | ESCC | negative regulation of mitotic cell cycle | 143/8552 | 235/18723 | 1.84e-06 | 2.15e-05 | 143 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:00107184 | Esophagus | ESCC | positive regulation of epithelial to mesenchymal transition | 40/8552 | 52/18723 | 4.25e-06 | 4.56e-05 | 40 |
GO:00073698 | Esophagus | ESCC | gastrulation | 115/8552 | 185/18723 | 4.35e-06 | 4.64e-05 | 115 |
GO:007084919 | Esophagus | ESCC | response to epidermal growth factor | 38/8552 | 49/18723 | 5.24e-06 | 5.49e-05 | 38 |
GO:007136419 | Esophagus | ESCC | cellular response to epidermal growth factor stimulus | 35/8552 | 45/18723 | 1.11e-05 | 1.04e-04 | 35 |
GO:000991310 | Esophagus | ESCC | epidermal cell differentiation | 122/8552 | 202/18723 | 1.69e-05 | 1.51e-04 | 122 |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:00456826 | Esophagus | ESCC | regulation of epidermis development | 46/8552 | 65/18723 | 3.65e-05 | 2.97e-04 | 46 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXC1 | SNV | Missense_Mutation | c.368N>C | p.Gln123Pro | p.Q123P | Q12948 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
FOXC1 | SNV | Missense_Mutation | novel | c.286G>T | p.Asp96Tyr | p.D96Y | Q12948 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
FOXC1 | SNV | Missense_Mutation | c.469N>T | p.Asp157Tyr | p.D157Y | Q12948 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
FOXC1 | SNV | Missense_Mutation | c.446G>A | p.Gly149Asp | p.G149D | Q12948 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A16F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FOXC1 | SNV | Missense_Mutation | novel | c.271N>C | p.Ile91Leu | p.I91L | Q12948 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FOXC1 | SNV | Missense_Mutation | novel | c.1580N>T | p.Ser527Ile | p.S527I | Q12948 | protein_coding | deleterious(0.01) | possibly_damaging(0.497) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXC1 | SNV | Missense_Mutation | c.1562C>T | p.Ser521Phe | p.S521F | Q12948 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-DD-A3A9-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FOXC1 | SNV | Missense_Mutation | novel | c.902N>G | p.Pro301Arg | p.P301R | Q12948 | protein_coding | tolerated(0.25) | benign(0) | TCGA-DD-AAD5-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
FOXC1 | SNV | Missense_Mutation | c.334T>A | p.Phe112Ile | p.F112I | Q12948 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FOXC1 | SNV | Missense_Mutation | c.534N>G | p.Asp178Glu | p.D178E | Q12948 | protein_coding | deleterious(0.01) | benign(0.1) | TCGA-J2-8194-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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