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Gene: FMO2 |
Gene summary for FMO2 |
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Gene information | Species | Human | Gene symbol | FMO2 | Gene ID | 2327 |
Gene name | flavin containing dimethylaniline monoxygenase 2 | |
Gene Alias | FMO1B1 | |
Cytomap | 1q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | B4E2Q9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2327 | FMO2 | LZE24D1 | Human | Esophagus | HGIN | 1.58e-02 | 5.95e-01 | 0.054 |
2327 | FMO2 | P44T-E | Human | Esophagus | ESCC | 1.11e-03 | 7.70e-01 | 0.1096 |
2327 | FMO2 | P57T-E | Human | Esophagus | ESCC | 2.84e-25 | 9.69e-01 | 0.0926 |
2327 | FMO2 | P83T-E | Human | Esophagus | ESCC | 7.23e-11 | -3.40e-02 | 0.1738 |
2327 | FMO2 | C57 | Human | Oral cavity | OSCC | 2.86e-08 | 5.68e-01 | 0.1679 |
2327 | FMO2 | C08 | Human | Oral cavity | OSCC | 8.20e-04 | 6.34e-01 | 0.1919 |
2327 | FMO2 | SYSMH6 | Human | Oral cavity | OSCC | 1.54e-20 | 6.95e-01 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:00067393 | Esophagus | ESCC | NADP metabolic process | 23/8552 | 35/18723 | 1.34e-02 | 4.38e-02 | 23 |
GO:000941018 | Oral cavity | OSCC | response to xenobiotic stimulus | 222/7305 | 462/18723 | 4.00e-05 | 3.48e-04 | 222 |
GO:00067392 | Oral cavity | OSCC | NADP metabolic process | 22/7305 | 35/18723 | 3.65e-03 | 1.51e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FMO2 | SNV | Missense_Mutation | novel | c.241N>G | p.Phe81Val | p.F81V | Q99518 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FMO2 | SNV | Missense_Mutation | c.293N>G | p.Phe98Cys | p.F98C | Q99518 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FMO2 | SNV | Missense_Mutation | c.437N>A | p.Cys146Tyr | p.C146Y | Q99518 | protein_coding | deleterious(0.01) | benign(0.149) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FMO2 | SNV | Missense_Mutation | rs372325848 | c.1420C>T | p.Arg474Cys | p.R474C | Q99518 | protein_coding | deleterious(0.01) | benign(0.168) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FMO2 | SNV | Missense_Mutation | c.606G>C | p.Glu202Asp | p.E202D | Q99518 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FMO2 | SNV | Missense_Mutation | novel | c.999C>A | p.Phe333Leu | p.F333L | Q99518 | protein_coding | tolerated(0.05) | benign(0.011) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FMO2 | SNV | Missense_Mutation | rs759051184 | c.871N>T | p.Arg291Cys | p.R291C | Q99518 | protein_coding | tolerated(0.41) | benign(0.062) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
FMO2 | deletion | Frame_Shift_Del | c.629delN | p.Phe211LeufsTer11 | p.F211Lfs*11 | Q99518 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
FMO2 | insertion | Frame_Shift_Ins | novel | c.302_303insA | p.Tyr103IlefsTer10 | p.Y103Ifs*10 | Q99518 | protein_coding | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
FMO2 | SNV | Missense_Mutation | novel | c.398N>A | p.Gly133Asp | p.G133D | Q99518 | protein_coding | deleterious(0.01) | possibly_damaging(0.831) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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