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Gene: FKBP11 |
Gene summary for FKBP11 |
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Gene information | Species | Human | Gene symbol | FKBP11 | Gene ID | 51303 |
Gene name | FKBP prolyl isomerase 11 | |
Gene Alias | FKBP19 | |
Cytomap | 12q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | E9PAR0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51303 | FKBP11 | AEH-subject1 | Human | Endometrium | AEH | 4.63e-19 | -4.42e-01 | -0.3059 |
51303 | FKBP11 | AEH-subject2 | Human | Endometrium | AEH | 4.85e-15 | -4.12e-01 | -0.2525 |
51303 | FKBP11 | AEH-subject3 | Human | Endometrium | AEH | 9.31e-13 | -3.70e-01 | -0.2576 |
51303 | FKBP11 | AEH-subject4 | Human | Endometrium | AEH | 9.27e-12 | -3.07e-01 | -0.2657 |
51303 | FKBP11 | EEC-subject1 | Human | Endometrium | EEC | 1.55e-10 | -3.06e-01 | -0.2682 |
51303 | FKBP11 | EEC-subject2 | Human | Endometrium | EEC | 1.43e-22 | -4.62e-01 | -0.2607 |
51303 | FKBP11 | EEC-subject3 | Human | Endometrium | EEC | 7.59e-32 | -3.72e-01 | -0.2525 |
51303 | FKBP11 | EEC-subject4 | Human | Endometrium | EEC | 3.13e-08 | -3.20e-01 | -0.2571 |
51303 | FKBP11 | EEC-subject5 | Human | Endometrium | EEC | 1.51e-09 | -3.69e-01 | -0.249 |
51303 | FKBP11 | GSM5276934 | Human | Endometrium | EEC | 1.37e-04 | -1.69e-01 | -0.0913 |
51303 | FKBP11 | GSM5276935 | Human | Endometrium | EEC | 5.05e-10 | -3.91e-01 | -0.123 |
51303 | FKBP11 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.76e-28 | -4.23e-01 | -0.1869 |
51303 | FKBP11 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.80e-25 | -5.16e-01 | -0.1875 |
51303 | FKBP11 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.48e-32 | -5.20e-01 | -0.1883 |
51303 | FKBP11 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 7.52e-34 | -4.86e-01 | -0.1934 |
51303 | FKBP11 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.06e-46 | -5.01e-01 | -0.1917 |
51303 | FKBP11 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.09e-45 | -5.20e-01 | -0.1916 |
51303 | FKBP11 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.04e-23 | -4.74e-01 | -0.1269 |
51303 | FKBP11 | LZE3D | Human | Esophagus | HGIN | 8.04e-04 | 5.44e-01 | 0.0668 |
51303 | FKBP11 | LZE4T | Human | Esophagus | ESCC | 1.76e-03 | 3.88e-02 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000645710 | Endometrium | AEH | protein folding | 61/2100 | 212/18723 | 1.86e-12 | 3.48e-10 | 61 |
GO:006107710 | Endometrium | AEH | chaperone-mediated protein folding | 23/2100 | 67/18723 | 4.82e-07 | 1.94e-05 | 23 |
GO:00004133 | Endometrium | AEH | protein peptidyl-prolyl isomerization | 13/2100 | 42/18723 | 4.74e-04 | 4.91e-03 | 13 |
GO:00182086 | Endometrium | AEH | peptidyl-proline modification | 16/2100 | 58/18723 | 4.75e-04 | 4.91e-03 | 16 |
GO:000645715 | Endometrium | EEC | protein folding | 63/2168 | 212/18723 | 6.82e-13 | 1.40e-10 | 63 |
GO:006107715 | Endometrium | EEC | chaperone-mediated protein folding | 23/2168 | 67/18723 | 8.50e-07 | 2.98e-05 | 23 |
GO:000041311 | Endometrium | EEC | protein peptidyl-prolyl isomerization | 14/2168 | 42/18723 | 1.69e-04 | 2.10e-03 | 14 |
GO:001820813 | Endometrium | EEC | peptidyl-proline modification | 17/2168 | 58/18723 | 2.11e-04 | 2.54e-03 | 17 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:0061077110 | Esophagus | ESCC | chaperone-mediated protein folding | 56/8552 | 67/18723 | 1.52e-10 | 4.36e-09 | 56 |
GO:001820816 | Esophagus | ESCC | peptidyl-proline modification | 46/8552 | 58/18723 | 1.59e-07 | 2.51e-06 | 46 |
GO:000041313 | Esophagus | ESCC | protein peptidyl-prolyl isomerization | 32/8552 | 42/18723 | 5.52e-05 | 4.27e-04 | 32 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:00610777 | Liver | Cirrhotic | chaperone-mediated protein folding | 40/4634 | 67/18723 | 1.24e-09 | 5.43e-08 | 40 |
GO:00182084 | Liver | Cirrhotic | peptidyl-proline modification | 26/4634 | 58/18723 | 6.65e-04 | 5.04e-03 | 26 |
GO:00004132 | Liver | Cirrhotic | protein peptidyl-prolyl isomerization | 19/4634 | 42/18723 | 3.00e-03 | 1.71e-02 | 19 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:006107712 | Liver | HCC | chaperone-mediated protein folding | 56/7958 | 67/18723 | 4.86e-12 | 2.14e-10 | 56 |
GO:001820811 | Liver | HCC | peptidyl-proline modification | 42/7958 | 58/18723 | 3.73e-06 | 4.85e-05 | 42 |
GO:00004131 | Liver | HCC | protein peptidyl-prolyl isomerization | 31/7958 | 42/18723 | 3.83e-05 | 3.80e-04 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FKBP11 | SNV | Missense_Mutation | c.359N>A | p.Gly120Glu | p.G120E | Q9NYL4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EP-A2KC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FKBP11 | SNV | Missense_Mutation | novel | c.365N>T | p.Arg122Leu | p.R122L | Q9NYL4 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
FKBP11 | SNV | Missense_Mutation | novel | c.545N>C | p.Arg182Thr | p.R182T | Q9NYL4 | protein_coding | tolerated_low_confidence(0.58) | benign(0) | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
FKBP11 | SNV | Missense_Mutation | novel | c.298N>G | p.Leu100Val | p.L100V | Q9NYL4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-H7-A76A-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FKBP11 | SNV | Missense_Mutation | c.538N>A | p.Ala180Thr | p.A180T | Q9NYL4 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FKBP11 | SNV | Missense_Mutation | novel | c.508N>T | p.Gly170Cys | p.G170C | Q9NYL4 | protein_coding | tolerated(0.11) | benign(0.011) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
FKBP11 | SNV | Missense_Mutation | c.351N>T | p.Leu117Phe | p.L117F | Q9NYL4 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FKBP11 | SNV | Missense_Mutation | rs763659306 | c.212G>A | p.Gly71Glu | p.G71E | Q9NYL4 | protein_coding | deleterious(0) | benign(0.154) | TCGA-VQ-A8PB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
FKBP11 | SNV | Missense_Mutation | rs537059154 | c.434G>A | p.Arg145Gln | p.R145Q | Q9NYL4 | protein_coding | tolerated(0.15) | benign(0.115) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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