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Gene: FIS1 |
Gene summary for FIS1 |
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Gene information | Species | Human | Gene symbol | FIS1 | Gene ID | 51024 |
Gene name | fission, mitochondrial 1 | |
Gene Alias | CGI-135 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | Q9Y3D6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51024 | FIS1 | CA_HPV_1 | Human | Cervix | CC | 1.19e-15 | -4.23e-01 | 0.0264 |
51024 | FIS1 | N_HPV_1 | Human | Cervix | N_HPV | 8.56e-05 | -7.47e-02 | 0.0079 |
51024 | FIS1 | CCI_1 | Human | Cervix | CC | 2.61e-08 | -6.96e-01 | 0.528 |
51024 | FIS1 | CCI_2 | Human | Cervix | CC | 3.07e-05 | -6.28e-01 | 0.5249 |
51024 | FIS1 | CCI_3 | Human | Cervix | CC | 9.10e-11 | -6.84e-01 | 0.516 |
51024 | FIS1 | CCII_1 | Human | Cervix | CC | 5.76e-21 | -7.53e-01 | 0.3249 |
51024 | FIS1 | sample3 | Human | Cervix | CC | 2.50e-06 | -3.17e-01 | 0.1387 |
51024 | FIS1 | H2 | Human | Cervix | HSIL_HPV | 6.67e-04 | -2.86e-01 | 0.0632 |
51024 | FIS1 | L1 | Human | Cervix | CC | 5.36e-05 | -1.98e-01 | 0.0802 |
51024 | FIS1 | T1 | Human | Cervix | CC | 6.09e-04 | -3.60e-01 | 0.0918 |
51024 | FIS1 | T3 | Human | Cervix | CC | 1.12e-09 | -3.03e-01 | 0.1389 |
51024 | FIS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.68e-08 | 2.60e-01 | 0.0155 |
51024 | FIS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.23e-14 | 5.57e-01 | -0.1808 |
51024 | FIS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.15e-09 | 3.54e-01 | -0.0811 |
51024 | FIS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.79e-04 | 1.92e-01 | -0.1088 |
51024 | FIS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.42e-19 | 4.73e-01 | -0.1954 |
51024 | FIS1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.47e-04 | 4.28e-01 | -0.2602 |
51024 | FIS1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.12e-04 | 6.05e-01 | -0.2196 |
51024 | FIS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.25e-15 | 4.69e-01 | -0.1207 |
51024 | FIS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.49e-09 | 5.38e-01 | -0.1526 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:009719310 | Cervix | CC | intrinsic apoptotic signaling pathway | 85/2311 | 288/18723 | 4.56e-15 | 6.46e-12 | 85 |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:200124210 | Cervix | CC | regulation of intrinsic apoptotic signaling pathway | 52/2311 | 164/18723 | 5.06e-11 | 1.01e-08 | 52 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:001095210 | Cervix | CC | positive regulation of peptidase activity | 54/2311 | 197/18723 | 8.06e-09 | 6.99e-07 | 54 |
GO:200011610 | Cervix | CC | regulation of cysteine-type endopeptidase activity | 61/2311 | 235/18723 | 8.69e-09 | 7.22e-07 | 61 |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:004328110 | Cervix | CC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 55/2311 | 209/18723 | 2.77e-08 | 1.95e-06 | 55 |
GO:190495110 | Cervix | CC | positive regulation of establishment of protein localization | 73/2311 | 319/18723 | 9.69e-08 | 5.25e-06 | 73 |
GO:001095010 | Cervix | CC | positive regulation of endopeptidase activity | 48/2311 | 179/18723 | 1.12e-07 | 5.71e-06 | 48 |
GO:20012357 | Cervix | CC | positive regulation of apoptotic signaling pathway | 37/2311 | 126/18723 | 2.70e-07 | 1.12e-05 | 37 |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
GO:000660510 | Cervix | CC | protein targeting | 68/2311 | 314/18723 | 2.17e-06 | 6.55e-05 | 68 |
GO:00903167 | Cervix | CC | positive regulation of intracellular protein transport | 41/2311 | 160/18723 | 3.24e-06 | 8.80e-05 | 41 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0413718 | Cervix | CC | Mitophagy - animal | 22/1267 | 72/8465 | 5.77e-04 | 2.75e-03 | 1.63e-03 | 22 |
hsa0413719 | Cervix | CC | Mitophagy - animal | 22/1267 | 72/8465 | 5.77e-04 | 2.75e-03 | 1.63e-03 | 22 |
hsa04137 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041371 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041372 | Colorectum | SER | Mitophagy - animal | 22/1580 | 72/8465 | 9.93e-03 | 4.78e-02 | 3.47e-02 | 22 |
hsa041373 | Colorectum | SER | Mitophagy - animal | 22/1580 | 72/8465 | 9.93e-03 | 4.78e-02 | 3.47e-02 | 22 |
hsa041374 | Colorectum | MSS | Mitophagy - animal | 27/1875 | 72/8465 | 2.17e-03 | 1.10e-02 | 6.76e-03 | 27 |
hsa041375 | Colorectum | MSS | Mitophagy - animal | 27/1875 | 72/8465 | 2.17e-03 | 1.10e-02 | 6.76e-03 | 27 |
hsa0413720 | Endometrium | AEH | Mitophagy - animal | 21/1197 | 72/8465 | 7.03e-04 | 4.86e-03 | 3.56e-03 | 21 |
hsa04137110 | Endometrium | AEH | Mitophagy - animal | 21/1197 | 72/8465 | 7.03e-04 | 4.86e-03 | 3.56e-03 | 21 |
hsa0413725 | Endometrium | EEC | Mitophagy - animal | 22/1237 | 72/8465 | 4.12e-04 | 3.30e-03 | 2.46e-03 | 22 |
hsa0413735 | Endometrium | EEC | Mitophagy - animal | 22/1237 | 72/8465 | 4.12e-04 | 3.30e-03 | 2.46e-03 | 22 |
hsa04137210 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0413738 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0413721 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
hsa0413731 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
hsa0413741 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0413751 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0413761 | Liver | Cyst | Mitophagy - animal | 9/339 | 72/8465 | 2.19e-03 | 1.91e-02 | 1.58e-02 | 9 |
hsa0413771 | Liver | Cyst | Mitophagy - animal | 9/339 | 72/8465 | 2.19e-03 | 1.91e-02 | 1.58e-02 | 9 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FIS1 | SNV | Missense_Mutation | novel | c.422N>A | p.Gly141Glu | p.G141E | Q9Y3D6 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
FIS1 | SNV | Missense_Mutation | novel | c.57G>T | p.Lys19Asn | p.K19N | Q9Y3D6 | protein_coding | tolerated(0.07) | benign(0.136) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FIS1 | SNV | Missense_Mutation | c.206N>T | p.Glu69Val | p.E69V | Q9Y3D6 | protein_coding | tolerated(0.12) | benign(0.027) | TCGA-ED-A459-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Ancillary | alvesin | CR | |
FIS1 | SNV | Missense_Mutation | c.37N>C | p.Asp13His | p.D13H | Q9Y3D6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FIS1 | SNV | Missense_Mutation | c.206N>G | p.Glu69Gly | p.E69G | Q9Y3D6 | protein_coding | tolerated(0.5) | benign(0.005) | TCGA-97-7547-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | vinorelbine | PD | |
FIS1 | SNV | Missense_Mutation | novel | c.52N>C | p.Glu18Gln | p.E18Q | Q9Y3D6 | protein_coding | deleterious(0.01) | possibly_damaging(0.773) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FIS1 | deletion | Frame_Shift_Del | novel | c.112delT | p.Tyr38ThrfsTer54 | p.Y38Tfs*54 | Q9Y3D6 | protein_coding | TCGA-44-2655-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
FIS1 | SNV | Missense_Mutation | novel | c.419N>T | p.Ala140Val | p.A140V | Q9Y3D6 | protein_coding | tolerated(1) | probably_damaging(0.944) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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