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Gene: FGFR1OP |
Gene summary for FGFR1OP |
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Gene information | Species | Human | Gene symbol | FGFR1OP | Gene ID | 11116 |
Gene name | centrosomal protein 43 | |
Gene Alias | FGFR1OP | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A0A087WV25 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11116 | FGFR1OP | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.46e-19 | -5.13e-01 | 0.0155 |
11116 | FGFR1OP | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.13e-11 | -5.13e-01 | -0.1808 |
11116 | FGFR1OP | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.70e-08 | -5.13e-01 | -0.0811 |
11116 | FGFR1OP | HTA11_78_2000001011 | Human | Colorectum | AD | 2.19e-13 | -5.13e-01 | -0.1088 |
11116 | FGFR1OP | HTA11_347_2000001011 | Human | Colorectum | AD | 4.63e-21 | -5.13e-01 | -0.1954 |
11116 | FGFR1OP | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.18e-08 | -5.13e-01 | -0.1207 |
11116 | FGFR1OP | HTA11_83_2000001011 | Human | Colorectum | SER | 1.01e-06 | -5.13e-01 | -0.1526 |
11116 | FGFR1OP | HTA11_696_2000001011 | Human | Colorectum | AD | 1.29e-28 | -5.13e-01 | -0.1464 |
11116 | FGFR1OP | HTA11_866_2000001011 | Human | Colorectum | AD | 9.10e-25 | -5.13e-01 | -0.1001 |
11116 | FGFR1OP | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.07e-15 | -5.13e-01 | -0.059 |
11116 | FGFR1OP | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.88e-02 | -5.13e-01 | -0.1706 |
11116 | FGFR1OP | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.23e-03 | -5.13e-01 | -0.2061 |
11116 | FGFR1OP | HTA11_546_2000001011 | Human | Colorectum | AD | 1.17e-05 | -5.13e-01 | -0.0842 |
11116 | FGFR1OP | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.35e-04 | -5.13e-01 | -0.0179 |
11116 | FGFR1OP | HTA11_866_3004761011 | Human | Colorectum | AD | 3.57e-17 | -5.13e-01 | 0.096 |
11116 | FGFR1OP | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.03e-03 | -5.13e-01 | 0.0528 |
11116 | FGFR1OP | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.79e-04 | -5.13e-01 | -0.0177 |
11116 | FGFR1OP | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.15e-10 | -5.13e-01 | 0.0338 |
11116 | FGFR1OP | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.10e-25 | -5.13e-01 | 0.0674 |
11116 | FGFR1OP | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.98e-04 | -5.13e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:004206012 | Liver | Cirrhotic | wound healing | 155/4634 | 422/18723 | 2.12e-08 | 7.56e-07 | 155 |
GO:004206022 | Liver | HCC | wound healing | 219/7958 | 422/18723 | 5.34e-05 | 5.04e-04 | 219 |
GO:004206020 | Oral cavity | OSCC | wound healing | 237/7305 | 422/18723 | 4.51e-13 | 2.18e-11 | 237 |
GO:0042060110 | Oral cavity | LP | wound healing | 139/4623 | 422/18723 | 7.10e-05 | 9.48e-04 | 139 |
GO:004206030 | Thyroid | HT | wound healing | 60/1272 | 422/18723 | 4.06e-08 | 2.69e-06 | 60 |
GO:0042060112 | Thyroid | PTC | wound healing | 190/5968 | 422/18723 | 7.72e-09 | 1.92e-07 | 190 |
GO:004206034 | Thyroid | ATC | wound healing | 210/6293 | 422/18723 | 3.33e-12 | 1.37e-10 | 210 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FGFR1OP | SNV | Missense_Mutation | novel | c.889G>T | p.Ala297Ser | p.A297S | O95684 | protein_coding | tolerated(0.79) | benign(0.001) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FGFR1OP | SNV | Missense_Mutation | c.130N>A | p.Ala44Thr | p.A44T | O95684 | protein_coding | deleterious(0) | benign(0.442) | TCGA-BS-A0T9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
FGFR1OP | SNV | Missense_Mutation | novel | c.792N>T | p.Glu264Asp | p.E264D | O95684 | protein_coding | tolerated(0.11) | probably_damaging(0.917) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FGFR1OP | SNV | Missense_Mutation | novel | c.173N>A | p.Val58Asp | p.V58D | O95684 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FGFR1OP | SNV | Missense_Mutation | rs145310318 | c.922N>G | p.Lys308Glu | p.K308E | O95684 | protein_coding | tolerated(0.08) | benign(0.293) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
FGFR1OP | SNV | Missense_Mutation | novel | c.217N>G | p.Leu73Val | p.L73V | O95684 | protein_coding | deleterious(0.03) | possibly_damaging(0.708) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FGFR1OP | SNV | Missense_Mutation | rs781301988 | c.557N>A | p.Ser186Asn | p.S186N | O95684 | protein_coding | deleterious(0.03) | benign(0.058) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FGFR1OP | insertion | Frame_Shift_Ins | novel | c.778_779insCCCTGGAACAGCCCTGGCAAGTGGC | p.Ile260ThrfsTer11 | p.I260Tfs*11 | O95684 | protein_coding | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
FGFR1OP | SNV | Missense_Mutation | novel | c.121N>C | p.Val41Leu | p.V41L | O95684 | protein_coding | deleterious(0) | benign(0.079) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FGFR1OP | SNV | Missense_Mutation | c.355G>A | p.Ala119Thr | p.A119T | O95684 | protein_coding | tolerated(0.19) | benign(0.194) | TCGA-75-6205-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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