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Gene: FCHO2 |
Gene summary for FCHO2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | FCHO2 | Gene ID | 115548 |
Gene name | FCH and mu domain containing endocytic adaptor 2 | |
Gene Alias | FCHO2 | |
Cytomap | 5q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q0JRZ9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115548 | FCHO2 | CCI_2 | Human | Cervix | CC | 6.49e-05 | 7.40e-01 | 0.5249 |
115548 | FCHO2 | CCI_3 | Human | Cervix | CC | 2.22e-05 | 6.26e-01 | 0.516 |
115548 | FCHO2 | H2 | Human | Cervix | HSIL_HPV | 6.74e-05 | 3.12e-01 | 0.0632 |
115548 | FCHO2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.71e-07 | -4.56e-01 | 0.0155 |
115548 | FCHO2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.19e-02 | -2.99e-01 | -0.1464 |
115548 | FCHO2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.57e-02 | -3.64e-01 | 0.096 |
115548 | FCHO2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.76e-04 | -3.30e-01 | 0.0674 |
115548 | FCHO2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.35e-03 | -2.79e-01 | 0.294 |
115548 | FCHO2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.84e-02 | -2.90e-01 | 0.3859 |
115548 | FCHO2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.35e-10 | -4.00e-01 | 0.3005 |
115548 | FCHO2 | F007 | Human | Colorectum | FAP | 3.22e-02 | -2.87e-01 | 0.1176 |
115548 | FCHO2 | A015-C-203 | Human | Colorectum | FAP | 3.06e-27 | -4.89e-01 | -0.1294 |
115548 | FCHO2 | A015-C-204 | Human | Colorectum | FAP | 4.58e-05 | -3.38e-01 | -0.0228 |
115548 | FCHO2 | A014-C-040 | Human | Colorectum | FAP | 2.92e-04 | -5.42e-01 | -0.1184 |
115548 | FCHO2 | A002-C-201 | Human | Colorectum | FAP | 3.72e-13 | -3.79e-01 | 0.0324 |
115548 | FCHO2 | A002-C-203 | Human | Colorectum | FAP | 1.00e-04 | -1.50e-01 | 0.2786 |
115548 | FCHO2 | A001-C-119 | Human | Colorectum | FAP | 1.66e-03 | -3.51e-01 | -0.1557 |
115548 | FCHO2 | A001-C-108 | Human | Colorectum | FAP | 8.25e-14 | -2.09e-01 | -0.0272 |
115548 | FCHO2 | A002-C-205 | Human | Colorectum | FAP | 9.71e-19 | -4.69e-01 | -0.1236 |
115548 | FCHO2 | A015-C-005 | Human | Colorectum | FAP | 4.00e-03 | -2.57e-01 | -0.0336 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00068987 | Cervix | CC | receptor-mediated endocytosis | 53/2311 | 244/18723 | 2.52e-05 | 4.29e-04 | 53 |
GO:00725836 | Cervix | CC | clathrin-dependent endocytosis | 16/2311 | 47/18723 | 9.56e-05 | 1.25e-03 | 16 |
GO:00484883 | Cervix | CC | synaptic vesicle endocytosis | 16/2311 | 62/18723 | 2.87e-03 | 1.91e-02 | 16 |
GO:01402383 | Cervix | CC | presynaptic endocytosis | 16/2311 | 62/18723 | 2.87e-03 | 1.91e-02 | 16 |
GO:00482686 | Cervix | CC | clathrin coat assembly | 7/2311 | 18/18723 | 3.99e-03 | 2.48e-02 | 7 |
GO:00364655 | Cervix | CC | synaptic vesicle recycling | 17/2311 | 75/18723 | 8.87e-03 | 4.53e-02 | 17 |
GO:00103243 | Cervix | CC | membrane invagination | 28/2311 | 144/18723 | 9.50e-03 | 4.72e-02 | 28 |
GO:001032411 | Cervix | HSIL_HPV | membrane invagination | 17/737 | 144/18723 | 5.28e-05 | 1.30e-03 | 17 |
GO:000689814 | Cervix | HSIL_HPV | receptor-mediated endocytosis | 20/737 | 244/18723 | 1.64e-03 | 1.78e-02 | 20 |
GO:007265913 | Cervix | HSIL_HPV | protein localization to plasma membrane | 21/737 | 284/18723 | 4.36e-03 | 3.68e-02 | 21 |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0072583 | Colorectum | AD | clathrin-dependent endocytosis | 24/3918 | 47/18723 | 4.60e-06 | 1.22e-04 | 24 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:0048268 | Colorectum | AD | clathrin coat assembly | 10/3918 | 18/18723 | 1.31e-03 | 1.15e-02 | 10 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00726592 | Colorectum | MSS | protein localization to plasma membrane | 113/3467 | 284/18723 | 3.23e-17 | 1.55e-14 | 113 |
GO:19907782 | Colorectum | MSS | protein localization to cell periphery | 120/3467 | 333/18723 | 2.02e-14 | 5.47e-12 | 120 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FCHO2 | SNV | Missense_Mutation | c.1526C>A | p.Ser509Tyr | p.S509Y | Q0JRZ9 | protein_coding | tolerated(0.41) | benign(0.049) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FCHO2 | SNV | Missense_Mutation | novel | c.24N>T | p.Glu8Asp | p.E8D | Q0JRZ9 | protein_coding | tolerated(0.49) | benign(0.011) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
FCHO2 | SNV | Missense_Mutation | rs368140227 | c.1588C>T | p.Arg530Trp | p.R530W | Q0JRZ9 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FCHO2 | SNV | Missense_Mutation | c.404C>A | p.Ala135Asp | p.A135D | Q0JRZ9 | protein_coding | tolerated(0.22) | benign(0.106) | TCGA-AZ-4681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FCHO2 | SNV | Missense_Mutation | novel | c.758N>C | p.Lys253Thr | p.K253T | Q0JRZ9 | protein_coding | deleterious(0.05) | possibly_damaging(0.493) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FCHO2 | SNV | Missense_Mutation | novel | c.1667N>C | p.Tyr556Ser | p.Y556S | Q0JRZ9 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FCHO2 | SNV | Missense_Mutation | c.2405N>T | p.Ala802Val | p.A802V | Q0JRZ9 | protein_coding | tolerated(0.14) | benign(0.1) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FCHO2 | SNV | Missense_Mutation | c.2414N>A | p.Arg805Gln | p.R805Q | Q0JRZ9 | protein_coding | tolerated(0.06) | benign(0.329) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
FCHO2 | SNV | Missense_Mutation | c.1051N>A | p.Glu351Lys | p.E351K | Q0JRZ9 | protein_coding | deleterious(0.01) | benign(0.027) | TCGA-AH-6897-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FCHO2 | deletion | Frame_Shift_Del | rs768979093 | c.44delA | p.Asn15IlefsTer11 | p.N15Ifs*11 | Q0JRZ9 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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