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Gene: FAM98C |
Gene summary for FAM98C |
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Gene information | Species | Human | Gene symbol | FAM98C | Gene ID | 147965 |
Gene name | family with sequence similarity 98 member C | |
Gene Alias | FAM98C | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q17RN3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147965 | FAM98C | LZE4T | Human | Esophagus | ESCC | 3.26e-02 | 1.01e-01 | 0.0811 |
147965 | FAM98C | LZE24T | Human | Esophagus | ESCC | 5.66e-22 | 5.58e-01 | 0.0596 |
147965 | FAM98C | P1T-E | Human | Esophagus | ESCC | 1.82e-26 | 1.13e+00 | 0.0875 |
147965 | FAM98C | P2T-E | Human | Esophagus | ESCC | 1.75e-09 | 2.00e-01 | 0.1177 |
147965 | FAM98C | P4T-E | Human | Esophagus | ESCC | 1.39e-18 | 4.62e-01 | 0.1323 |
147965 | FAM98C | P5T-E | Human | Esophagus | ESCC | 8.42e-31 | 5.48e-01 | 0.1327 |
147965 | FAM98C | P8T-E | Human | Esophagus | ESCC | 9.10e-46 | 8.16e-01 | 0.0889 |
147965 | FAM98C | P9T-E | Human | Esophagus | ESCC | 2.20e-06 | 1.94e-01 | 0.1131 |
147965 | FAM98C | P10T-E | Human | Esophagus | ESCC | 4.10e-20 | 3.22e-01 | 0.116 |
147965 | FAM98C | P11T-E | Human | Esophagus | ESCC | 8.12e-11 | 4.50e-01 | 0.1426 |
147965 | FAM98C | P12T-E | Human | Esophagus | ESCC | 5.10e-21 | 3.74e-01 | 0.1122 |
147965 | FAM98C | P15T-E | Human | Esophagus | ESCC | 5.59e-29 | 5.42e-01 | 0.1149 |
147965 | FAM98C | P16T-E | Human | Esophagus | ESCC | 3.29e-12 | 2.29e-01 | 0.1153 |
147965 | FAM98C | P17T-E | Human | Esophagus | ESCC | 1.13e-06 | 1.98e-01 | 0.1278 |
147965 | FAM98C | P19T-E | Human | Esophagus | ESCC | 6.18e-12 | 7.04e-01 | 0.1662 |
147965 | FAM98C | P20T-E | Human | Esophagus | ESCC | 4.31e-29 | 6.65e-01 | 0.1124 |
147965 | FAM98C | P21T-E | Human | Esophagus | ESCC | 1.82e-20 | 2.32e-01 | 0.1617 |
147965 | FAM98C | P22T-E | Human | Esophagus | ESCC | 2.46e-22 | 4.18e-01 | 0.1236 |
147965 | FAM98C | P23T-E | Human | Esophagus | ESCC | 5.52e-22 | 6.43e-01 | 0.108 |
147965 | FAM98C | P24T-E | Human | Esophagus | ESCC | 3.91e-10 | 2.14e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM98C | SNV | Missense_Mutation | rs768245449 | c.388T>C | p.Cys130Arg | p.C130R | Q17RN3 | protein_coding | tolerated(0.37) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM98C | SNV | Missense_Mutation | novel | c.506N>A | p.Pro169His | p.P169H | Q17RN3 | protein_coding | deleterious(0.03) | possibly_damaging(0.753) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
FAM98C | SNV | Missense_Mutation | c.562G>C | p.Glu188Gln | p.E188Q | Q17RN3 | protein_coding | deleterious(0.03) | possibly_damaging(0.478) | TCGA-AJ-A2QM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
FAM98C | SNV | Missense_Mutation | rs371060977 | c.880G>A | p.Val294Met | p.V294M | Q17RN3 | protein_coding | tolerated(0.14) | benign(0.017) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
FAM98C | SNV | Missense_Mutation | c.523G>A | p.Ala175Thr | p.A175T | Q17RN3 | protein_coding | tolerated(0.3) | probably_damaging(0.94) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM98C | SNV | Missense_Mutation | rs200637370 | c.1027N>T | p.Arg343Cys | p.R343C | Q17RN3 | protein_coding | deleterious(0) | possibly_damaging(0.732) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM98C | SNV | Missense_Mutation | c.635A>C | p.Glu212Ala | p.E212A | Q17RN3 | protein_coding | deleterious(0) | benign(0.418) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM98C | SNV | Missense_Mutation | novel | c.116N>G | p.Phe39Cys | p.F39C | Q17RN3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
FAM98C | SNV | Missense_Mutation | c.523G>A | p.Ala175Thr | p.A175T | Q17RN3 | protein_coding | tolerated(0.3) | probably_damaging(0.94) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM98C | SNV | Missense_Mutation | rs773547682 | c.995G>A | p.Arg332Gln | p.R332Q | Q17RN3 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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