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Gene: FAM72B |
Gene summary for FAM72B |
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Gene information | Species | Human | Gene symbol | FAM72B | Gene ID | 653820 |
Gene name | family with sequence similarity 72 member B | |
Gene Alias | p17 | |
Cytomap | 1p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86X60 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
653820 | FAM72B | P4T-E | Human | Esophagus | ESCC | 2.20e-02 | 1.02e-01 | 0.1323 |
653820 | FAM72B | P5T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.68e-02 | 0.1327 |
653820 | FAM72B | P24T-E | Human | Esophagus | ESCC | 3.52e-19 | 7.62e-01 | 0.1287 |
653820 | FAM72B | P32T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.11e-01 | 0.1666 |
653820 | FAM72B | P52T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.02e-01 | 0.1555 |
653820 | FAM72B | P75T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.30e-01 | 0.1125 |
653820 | FAM72B | P83T-E | Human | Esophagus | ESCC | 8.77e-03 | 1.37e-01 | 0.1738 |
653820 | FAM72B | P91T-E | Human | Esophagus | ESCC | 5.34e-06 | 5.50e-01 | 0.1828 |
653820 | FAM72B | P130T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.22e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM72B | SNV | Missense_Mutation | novel | c.353N>T | p.Thr118Ile | p.T118I | Q86X60 | protein_coding | deleterious(0.03) | possibly_damaging(0.571) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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