|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: FAM72B |
Gene summary for FAM72B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FAM72B | Gene ID | 653820 |
| Gene name | family with sequence similarity 72 member B | |
| Gene Alias | p17 | |
| Cytomap | 1p11.2 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86X60 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 653820 | FAM72B | P4T-E | Human | Esophagus | ESCC | 2.20e-02 | 1.02e-01 | 0.1323 |
| 653820 | FAM72B | P5T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.68e-02 | 0.1327 |
| 653820 | FAM72B | P24T-E | Human | Esophagus | ESCC | 3.52e-19 | 7.62e-01 | 0.1287 |
| 653820 | FAM72B | P32T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.11e-01 | 0.1666 |
| 653820 | FAM72B | P52T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.02e-01 | 0.1555 |
| 653820 | FAM72B | P75T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.30e-01 | 0.1125 |
| 653820 | FAM72B | P83T-E | Human | Esophagus | ESCC | 8.77e-03 | 1.37e-01 | 0.1738 |
| 653820 | FAM72B | P91T-E | Human | Esophagus | ESCC | 5.34e-06 | 5.50e-01 | 0.1828 |
| 653820 | FAM72B | P130T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.22e-01 | 0.1676 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FAM72B | SNV | Missense_Mutation | novel | c.353N>T | p.Thr118Ile | p.T118I | Q86X60 | protein_coding | deleterious(0.03) | possibly_damaging(0.571) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |