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Gene: FAM58A |
Gene summary for FAM58A |
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Gene information | Species | Human | Gene symbol | FAM58A | Gene ID | 92002 |
Gene name | cyclin Q | |
Gene Alias | CycM | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N1B3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92002 | FAM58A | P1T-E | Human | Esophagus | ESCC | 3.61e-10 | 4.62e-01 | 0.0875 |
92002 | FAM58A | P2T-E | Human | Esophagus | ESCC | 1.28e-40 | 7.58e-01 | 0.1177 |
92002 | FAM58A | P4T-E | Human | Esophagus | ESCC | 4.23e-26 | 6.40e-01 | 0.1323 |
92002 | FAM58A | P5T-E | Human | Esophagus | ESCC | 1.85e-27 | 5.27e-01 | 0.1327 |
92002 | FAM58A | P8T-E | Human | Esophagus | ESCC | 2.42e-09 | 1.76e-01 | 0.0889 |
92002 | FAM58A | P9T-E | Human | Esophagus | ESCC | 1.29e-23 | 5.45e-01 | 0.1131 |
92002 | FAM58A | P10T-E | Human | Esophagus | ESCC | 1.30e-40 | 7.54e-01 | 0.116 |
92002 | FAM58A | P11T-E | Human | Esophagus | ESCC | 3.00e-05 | 2.61e-01 | 0.1426 |
92002 | FAM58A | P12T-E | Human | Esophagus | ESCC | 8.49e-16 | 3.60e-01 | 0.1122 |
92002 | FAM58A | P15T-E | Human | Esophagus | ESCC | 2.38e-07 | 2.14e-01 | 0.1149 |
92002 | FAM58A | P16T-E | Human | Esophagus | ESCC | 2.20e-11 | 2.02e-01 | 0.1153 |
92002 | FAM58A | P19T-E | Human | Esophagus | ESCC | 6.36e-04 | 5.13e-01 | 0.1662 |
92002 | FAM58A | P20T-E | Human | Esophagus | ESCC | 6.92e-13 | 2.00e-01 | 0.1124 |
92002 | FAM58A | P21T-E | Human | Esophagus | ESCC | 1.09e-30 | 5.66e-01 | 0.1617 |
92002 | FAM58A | P22T-E | Human | Esophagus | ESCC | 2.72e-62 | 9.88e-01 | 0.1236 |
92002 | FAM58A | P23T-E | Human | Esophagus | ESCC | 4.18e-43 | 1.02e+00 | 0.108 |
92002 | FAM58A | P24T-E | Human | Esophagus | ESCC | 5.21e-19 | 4.11e-01 | 0.1287 |
92002 | FAM58A | P26T-E | Human | Esophagus | ESCC | 5.09e-21 | 4.54e-01 | 0.1276 |
92002 | FAM58A | P27T-E | Human | Esophagus | ESCC | 3.55e-05 | 1.54e-01 | 0.1055 |
92002 | FAM58A | P28T-E | Human | Esophagus | ESCC | 5.15e-38 | 7.43e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM58A | SNV | Missense_Mutation | c.454N>A | p.Leu152Ile | p.L152I | Q8N1B3 | protein_coding | tolerated(0.05) | possibly_damaging(0.743) | TCGA-B5-A0JV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FAM58A | SNV | Missense_Mutation | c.231N>G | p.Ile77Met | p.I77M | Q8N1B3 | protein_coding | deleterious(0.02) | possibly_damaging(0.748) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
FAM58A | SNV | Missense_Mutation | c.398N>A | p.Arg133His | p.R133H | Q8N1B3 | protein_coding | tolerated(0.13) | benign(0.011) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM58A | SNV | Missense_Mutation | novel | c.314G>A | p.Gly105Asp | p.G105D | Q8N1B3 | protein_coding | deleterious(0.02) | benign(0.076) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | rs782206940 | c.313G>A | p.Gly105Ser | p.G105S | Q8N1B3 | protein_coding | tolerated(1) | benign(0) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | c.174N>A | p.Phe58Leu | p.F58L | Q8N1B3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM58A | SNV | Missense_Mutation | rs782206940 | c.313G>A | p.Gly105Ser | p.G105S | Q8N1B3 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A17R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | novel | c.574G>A | p.Ala192Thr | p.A192T | Q8N1B3 | protein_coding | deleterious(0.03) | probably_damaging(0.982) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | rs781987078 | c.200N>G | p.Tyr67Cys | p.Y67C | Q8N1B3 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | rs781921854 | c.241N>A | p.Gly81Ser | p.G81S | Q8N1B3 | protein_coding | tolerated(0.12) | benign(0.217) | TCGA-22-4601-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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