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Gene: FAM45A |
Gene summary for FAM45A |
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Gene information | Species | Human | Gene symbol | FAM45A | Gene ID | 404636 |
Gene name | DENN domain containing 10 | |
Gene Alias | FAM45A | |
Cytomap | 10q26.11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8TCE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
404636 | FAM45A | P1T-E | Human | Esophagus | ESCC | 1.81e-06 | 4.71e-01 | 0.0875 |
404636 | FAM45A | P2T-E | Human | Esophagus | ESCC | 1.29e-31 | 6.04e-01 | 0.1177 |
404636 | FAM45A | P4T-E | Human | Esophagus | ESCC | 2.44e-35 | 8.04e-01 | 0.1323 |
404636 | FAM45A | P5T-E | Human | Esophagus | ESCC | 7.59e-32 | 6.36e-01 | 0.1327 |
404636 | FAM45A | P8T-E | Human | Esophagus | ESCC | 3.72e-34 | 3.38e-01 | 0.0889 |
404636 | FAM45A | P9T-E | Human | Esophagus | ESCC | 6.59e-19 | 3.53e-01 | 0.1131 |
404636 | FAM45A | P10T-E | Human | Esophagus | ESCC | 2.07e-20 | 2.17e-01 | 0.116 |
404636 | FAM45A | P11T-E | Human | Esophagus | ESCC | 1.32e-16 | 5.08e-01 | 0.1426 |
404636 | FAM45A | P12T-E | Human | Esophagus | ESCC | 9.14e-27 | 6.71e-01 | 0.1122 |
404636 | FAM45A | P15T-E | Human | Esophagus | ESCC | 3.63e-30 | 5.01e-01 | 0.1149 |
404636 | FAM45A | P16T-E | Human | Esophagus | ESCC | 4.77e-38 | 6.66e-01 | 0.1153 |
404636 | FAM45A | P17T-E | Human | Esophagus | ESCC | 7.02e-11 | 3.97e-01 | 0.1278 |
404636 | FAM45A | P19T-E | Human | Esophagus | ESCC | 7.69e-11 | 6.46e-01 | 0.1662 |
404636 | FAM45A | P20T-E | Human | Esophagus | ESCC | 6.18e-16 | 2.91e-01 | 0.1124 |
404636 | FAM45A | P21T-E | Human | Esophagus | ESCC | 6.32e-34 | 5.35e-01 | 0.1617 |
404636 | FAM45A | P22T-E | Human | Esophagus | ESCC | 1.76e-27 | 4.28e-01 | 0.1236 |
404636 | FAM45A | P23T-E | Human | Esophagus | ESCC | 1.88e-31 | 6.54e-01 | 0.108 |
404636 | FAM45A | P24T-E | Human | Esophagus | ESCC | 9.14e-22 | 5.17e-01 | 0.1287 |
404636 | FAM45A | P26T-E | Human | Esophagus | ESCC | 4.05e-34 | 6.57e-01 | 0.1276 |
404636 | FAM45A | P27T-E | Human | Esophagus | ESCC | 2.64e-33 | 6.06e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM45A | SNV | Missense_Mutation | novel | c.837N>T | p.Met279Ile | p.M279I | Q8TCE6 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM45A | SNV | Missense_Mutation | novel | c.104N>T | p.Thr35Met | p.T35M | Q8TCE6 | protein_coding | tolerated(0.14) | benign(0.213) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FAM45A | SNV | Missense_Mutation | c.206N>C | p.Phe69Ser | p.F69S | Q8TCE6 | protein_coding | deleterious(0) | benign(0.391) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM45A | SNV | Missense_Mutation | novel | c.728N>T | p.Ser243Ile | p.S243I | Q8TCE6 | protein_coding | tolerated(0.09) | benign(0.017) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
FAM45A | SNV | Missense_Mutation | novel | c.623N>C | p.Gln208Pro | p.Q208P | Q8TCE6 | protein_coding | tolerated(0.07) | possibly_damaging(0.895) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM45A | SNV | Missense_Mutation | c.1054N>A | p.Glu352Lys | p.E352K | Q8TCE6 | protein_coding | deleterious(0) | possibly_damaging(0.551) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM45A | SNV | Missense_Mutation | novel | c.950A>G | p.Glu317Gly | p.E317G | Q8TCE6 | protein_coding | tolerated(0.11) | benign(0.079) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM45A | SNV | Missense_Mutation | c.545G>T | p.Arg182Ile | p.R182I | Q8TCE6 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FAM45A | SNV | Missense_Mutation | c.872A>C | p.Glu291Ala | p.E291A | Q8TCE6 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FAM45A | insertion | Frame_Shift_Ins | novel | c.519dupA | p.His174ThrfsTer50 | p.H174Tfs*50 | Q8TCE6 | protein_coding | TCGA-DD-AAW3-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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