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Gene: FAM212A |
Gene summary for FAM212A |
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Gene information | Species | Human | Gene symbol | FAM212A | Gene ID | 389119 |
Gene name | inka box actin regulator 1 | |
Gene Alias | C3orf54 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96EL1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389119 | FAM212A | C04 | Human | Oral cavity | OSCC | 8.49e-03 | 4.42e-01 | 0.2633 |
389119 | FAM212A | C21 | Human | Oral cavity | OSCC | 3.73e-09 | 3.71e-01 | 0.2678 |
389119 | FAM212A | C30 | Human | Oral cavity | OSCC | 4.80e-09 | 7.59e-01 | 0.3055 |
389119 | FAM212A | C38 | Human | Oral cavity | OSCC | 2.22e-02 | 7.66e-01 | 0.172 |
389119 | FAM212A | C43 | Human | Oral cavity | OSCC | 2.14e-07 | 1.61e-01 | 0.1704 |
389119 | FAM212A | C46 | Human | Oral cavity | OSCC | 3.05e-08 | 3.59e-01 | 0.1673 |
389119 | FAM212A | C06 | Human | Oral cavity | OSCC | 9.36e-03 | 7.01e-01 | 0.2699 |
389119 | FAM212A | C08 | Human | Oral cavity | OSCC | 1.25e-08 | 1.23e-01 | 0.1919 |
389119 | FAM212A | LN46 | Human | Oral cavity | OSCC | 5.62e-03 | 2.16e-01 | 0.1666 |
389119 | FAM212A | SYSMH1 | Human | Oral cavity | OSCC | 1.94e-02 | 9.30e-02 | 0.1127 |
389119 | FAM212A | SYSMH2 | Human | Oral cavity | OSCC | 3.06e-05 | 2.13e-01 | 0.2326 |
389119 | FAM212A | SYSMH3 | Human | Oral cavity | OSCC | 2.21e-20 | 5.15e-01 | 0.2442 |
389119 | FAM212A | SYSMH4 | Human | Oral cavity | OSCC | 2.81e-06 | 1.52e-01 | 0.1226 |
389119 | FAM212A | P1_cSCC | Human | Skin | cSCC | 5.67e-32 | 8.84e-01 | 0.0292 |
389119 | FAM212A | P2_cSCC | Human | Skin | cSCC | 4.45e-26 | 6.00e-01 | -0.024 |
389119 | FAM212A | P4_cSCC | Human | Skin | cSCC | 1.83e-35 | 7.23e-01 | -0.00290000000000005 |
389119 | FAM212A | P10_cSCC | Human | Skin | cSCC | 6.80e-38 | 9.38e-01 | 0.1017 |
389119 | FAM212A | cSCC_p1 | Human | Skin | cSCC | 5.98e-08 | 3.11e-01 | -0.1916 |
389119 | FAM212A | cSCC_p10 | Human | Skin | cSCC | 1.04e-09 | 3.48e-01 | -0.2095 |
389119 | FAM212A | cSCC_p11 | Human | Skin | cSCC | 4.63e-13 | 2.79e-01 | -0.2102 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM212A | SNV | Missense_Mutation | novel | c.860N>C | p.Leu287Pro | p.L287P | Q96EL1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.914) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM212A | SNV | Missense_Mutation | novel | c.230N>T | p.Thr77Ile | p.T77I | Q96EL1 | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM212A | insertion | Nonsense_Mutation | novel | c.64_65insAAATCAATAATATGTATGCAATAAAACACTTCAGCTGAGGACA | p.Gly22GlufsTer13 | p.G22Efs*13 | Q96EL1 | protein_coding | TCGA-D1-A0ZP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | ||
FAM212A | SNV | Missense_Mutation | c.263N>C | p.Arg88Thr | p.R88T | Q96EL1 | protein_coding | tolerated(0.49) | benign(0.08) | TCGA-55-8510-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM212A | SNV | Missense_Mutation | c.224N>A | p.Val75Glu | p.V75E | Q96EL1 | protein_coding | tolerated(1) | benign(0.055) | TCGA-97-7554-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | alimta | SD | |
FAM212A | SNV | Missense_Mutation | c.414N>A | p.Ser138Arg | p.S138R | Q96EL1 | protein_coding | tolerated(0.18) | benign(0) | TCGA-97-A4M7-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM212A | SNV | Missense_Mutation | novel | c.157N>G | p.Ser53Ala | p.S53A | Q96EL1 | protein_coding | deleterious(0.01) | benign(0.373) | TCGA-UF-A7JT-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
FAM212A | SNV | Missense_Mutation | c.811N>T | p.Met271Leu | p.M271L | Q96EL1 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-BR-4191-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | SD | |
FAM212A | SNV | Missense_Mutation | c.455N>A | p.Arg152Gln | p.R152Q | Q96EL1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM212A | SNV | Missense_Mutation | rs766185057 | c.650G>A | p.Arg217His | p.R217H | Q96EL1 | protein_coding | deleterious(0.03) | possibly_damaging(0.901) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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