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Gene: FAM169A |
Gene summary for FAM169A |
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Gene information | Species | Human | Gene symbol | FAM169A | Gene ID | 26049 |
Gene name | family with sequence similarity 169 member A | |
Gene Alias | SLAP75 | |
Cytomap | 5q13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9Y6X4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26049 | FAM169A | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.49e-02 | -6.07e-02 | -0.1869 |
26049 | FAM169A | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.01e-06 | -5.05e-02 | -0.1883 |
26049 | FAM169A | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.32e-03 | -7.79e-03 | -0.1917 |
26049 | FAM169A | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 7.26e-04 | 1.55e-02 | -0.1916 |
26049 | FAM169A | NAFLD1 | Human | Liver | NAFLD | 2.53e-03 | 3.85e-01 | -0.04 |
26049 | FAM169A | HCC1_Meng | Human | Liver | HCC | 3.68e-09 | 1.76e-02 | 0.0246 |
26049 | FAM169A | HCC1 | Human | Liver | HCC | 8.00e-06 | 2.18e+00 | 0.5336 |
26049 | FAM169A | HCC2 | Human | Liver | HCC | 3.16e-04 | 3.03e+00 | 0.5341 |
26049 | FAM169A | HCC5 | Human | Liver | HCC | 2.64e-07 | 1.80e+00 | 0.4932 |
26049 | FAM169A | S014 | Human | Liver | HCC | 8.22e-07 | 2.89e-01 | 0.2254 |
26049 | FAM169A | S015 | Human | Liver | HCC | 1.42e-13 | 4.35e-01 | 0.2375 |
26049 | FAM169A | S016 | Human | Liver | HCC | 5.61e-15 | 3.70e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer | ||
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM169A | SNV | Missense_Mutation | c.868G>A | p.Glu290Lys | p.E290K | Q9Y6X4 | protein_coding | tolerated(0.13) | benign(0.123) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM169A | SNV | Missense_Mutation | novel | c.625N>T | p.Asp209Tyr | p.D209Y | Q9Y6X4 | protein_coding | deleterious(0) | possibly_damaging(0.73) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM169A | SNV | Missense_Mutation | rs773364018 | c.35N>A | p.Ser12Asn | p.S12N | Q9Y6X4 | protein_coding | deleterious(0.01) | possibly_damaging(0.474) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM169A | SNV | Missense_Mutation | c.362G>A | p.Arg121Gln | p.R121Q | Q9Y6X4 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
FAM169A | SNV | Missense_Mutation | c.4G>A | p.Ala2Thr | p.A2T | Q9Y6X4 | protein_coding | deleterious(0.04) | possibly_damaging(0.712) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM169A | SNV | Missense_Mutation | c.51N>C | p.Glu17Asp | p.E17D | Q9Y6X4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM169A | SNV | Missense_Mutation | c.56C>T | p.Ser19Phe | p.S19F | Q9Y6X4 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM169A | SNV | Missense_Mutation | novel | c.137N>A | p.Pro46His | p.P46H | Q9Y6X4 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM169A | SNV | Missense_Mutation | c.1171N>T | p.Gly391Trp | p.G391W | Q9Y6X4 | protein_coding | deleterious(0.02) | possibly_damaging(0.698) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM169A | SNV | Missense_Mutation | c.1011N>T | p.Lys337Asn | p.K337N | Q9Y6X4 | protein_coding | deleterious(0) | possibly_damaging(0.836) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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