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Gene: FAM155A |
Gene summary for FAM155A |
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Gene information | Species | Human | Gene symbol | FAM155A | Gene ID | 728215 |
Gene name | NALCN channel auxiliary factor 1 | |
Gene Alias | FAM155A | |
Cytomap | 13q33.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B1AL88 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
728215 | FAM155A | HTA11_78_2000001011 | Human | Colorectum | AD | 6.80e-04 | 4.64e-01 | -0.1088 |
728215 | FAM155A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.31e-05 | 4.62e-01 | -0.059 |
728215 | FAM155A | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.23e-03 | 3.41e-01 | 0.0338 |
728215 | FAM155A | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.20e-05 | 4.78e-01 | 0.0588 |
728215 | FAM155A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.63e-13 | 8.23e-01 | 0.2585 |
728215 | FAM155A | F072B | Human | Colorectum | FAP | 2.11e-24 | 7.94e-01 | 0.257 |
728215 | FAM155A | AEH-subject1 | Human | Endometrium | AEH | 4.46e-58 | 1.09e+00 | -0.3059 |
728215 | FAM155A | AEH-subject2 | Human | Endometrium | AEH | 4.54e-35 | 9.65e-01 | -0.2525 |
728215 | FAM155A | AEH-subject3 | Human | Endometrium | AEH | 2.18e-44 | 1.00e+00 | -0.2576 |
728215 | FAM155A | AEH-subject4 | Human | Endometrium | AEH | 1.70e-34 | 9.98e-01 | -0.2657 |
728215 | FAM155A | AEH-subject5 | Human | Endometrium | AEH | 3.96e-49 | 1.27e+00 | -0.2953 |
728215 | FAM155A | EEC-subject1 | Human | Endometrium | EEC | 1.78e-49 | 1.06e+00 | -0.2682 |
728215 | FAM155A | EEC-subject2 | Human | Endometrium | EEC | 8.03e-03 | -1.11e-02 | -0.2607 |
728215 | FAM155A | EEC-subject3 | Human | Endometrium | EEC | 1.71e-26 | 7.11e-01 | -0.2525 |
728215 | FAM155A | EEC-subject4 | Human | Endometrium | EEC | 2.35e-10 | 4.37e-01 | -0.2571 |
728215 | FAM155A | EEC-subject5 | Human | Endometrium | EEC | 5.97e-07 | -5.84e-02 | -0.249 |
728215 | FAM155A | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 7.52e-05 | -9.20e-02 | -0.1883 |
728215 | FAM155A | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.42e-15 | 4.26e-01 | -0.1934 |
728215 | FAM155A | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.72e-06 | -1.02e-01 | -0.1917 |
728215 | FAM155A | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.78e-05 | -9.51e-02 | -0.1916 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM155A | SNV | Missense_Mutation | c.878N>T | p.Glu293Val | p.E293V | B1AL88 | protein_coding | deleterious(0.01) | benign(0.09) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM155A | SNV | Missense_Mutation | c.1232N>C | p.Arg411Thr | p.R411T | B1AL88 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AF-6672-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Ancillary | leucovorin | PD | |
FAM155A | SNV | Missense_Mutation | c.656N>T | p.Ser219Leu | p.S219L | B1AL88 | protein_coding | deleterious(0) | benign(0.358) | TCGA-AG-3902-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM155A | SNV | Missense_Mutation | c.1019N>T | p.Arg340Met | p.R340M | B1AL88 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
FAM155A | SNV | Missense_Mutation | novel | c.965T>G | p.Phe322Cys | p.F322C | B1AL88 | protein_coding | tolerated(0.18) | benign(0.386) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM155A | insertion | Frame_Shift_Ins | rs775872623 | c.595_596insG | p.Ala199GlyfsTer29 | p.A199Gfs*29 | B1AL88 | protein_coding | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
FAM155A | SNV | Missense_Mutation | rs767026891 | c.1346N>T | p.Thr449Met | p.T449M | B1AL88 | protein_coding | deleterious(0.01) | possibly_damaging(0.46) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM155A | SNV | Missense_Mutation | novel | c.940N>C | p.Ser314Pro | p.S314P | B1AL88 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM155A | SNV | Missense_Mutation | novel | c.939N>G | p.Cys313Trp | p.C313W | B1AL88 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
FAM155A | SNV | Missense_Mutation | novel | c.1255C>A | p.Leu419Met | p.L419M | B1AL88 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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