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Gene: FAM135A |
Gene summary for FAM135A |
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Gene information | Species | Human | Gene symbol | FAM135A | Gene ID | 57579 |
Gene name | family with sequence similarity 135 member A | |
Gene Alias | KIAA1411 | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9P2D6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57579 | FAM135A | CCI_1 | Human | Cervix | CC | 2.39e-10 | 1.14e+00 | 0.528 |
57579 | FAM135A | CCI_2 | Human | Cervix | CC | 1.56e-06 | 1.04e+00 | 0.5249 |
57579 | FAM135A | CCI_3 | Human | Cervix | CC | 2.58e-07 | 6.73e-01 | 0.516 |
57579 | FAM135A | T3 | Human | Cervix | CC | 4.58e-03 | 1.14e-01 | 0.1389 |
57579 | FAM135A | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.70e-36 | -8.57e-01 | 0.0155 |
57579 | FAM135A | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.14e-03 | -4.68e-01 | -0.1808 |
57579 | FAM135A | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.28e-05 | -9.02e-01 | 0.0216 |
57579 | FAM135A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.72e-02 | 3.92e-01 | -0.1954 |
57579 | FAM135A | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.61e-15 | -7.55e-01 | -0.1207 |
57579 | FAM135A | HTA11_696_2000001011 | Human | Colorectum | AD | 3.22e-09 | -4.22e-01 | -0.1464 |
57579 | FAM135A | HTA11_866_2000001011 | Human | Colorectum | AD | 5.28e-03 | -3.11e-01 | -0.1001 |
57579 | FAM135A | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.01e-03 | -5.92e-01 | -0.1462 |
57579 | FAM135A | HTA11_9341_2000001011 | Human | Colorectum | SER | 9.78e-05 | -8.98e-01 | -0.00410000000000005 |
57579 | FAM135A | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.04e-05 | -5.83e-01 | -0.0179 |
57579 | FAM135A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.54e-31 | -8.45e-01 | 0.096 |
57579 | FAM135A | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.26e-02 | -7.13e-01 | 0.0446 |
57579 | FAM135A | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.45e-05 | -8.15e-01 | 0.0451 |
57579 | FAM135A | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.88e-07 | -7.69e-01 | 0.0528 |
57579 | FAM135A | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.00e-06 | -7.95e-01 | 0.0131 |
57579 | FAM135A | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.40e-02 | -6.32e-01 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM135A | SNV | Missense_Mutation | rs764330783 | c.4415G>A | p.Arg1472His | p.R1472H | Q9P2D6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM135A | SNV | Missense_Mutation | novel | c.20T>C | p.Met7Thr | p.M7T | Q9P2D6 | protein_coding | tolerated(1) | possibly_damaging(0.885) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
FAM135A | SNV | Missense_Mutation | novel | c.1341N>A | p.Ser447Arg | p.S447R | Q9P2D6 | protein_coding | tolerated(0.46) | benign(0.003) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FAM135A | SNV | Missense_Mutation | rs778399413 | c.3146N>T | p.Thr1049Met | p.T1049M | Q9P2D6 | protein_coding | deleterious(0.01) | probably_damaging(0.944) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM135A | SNV | Missense_Mutation | c.2333C>T | p.Ser778Phe | p.S778F | Q9P2D6 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM135A | SNV | Missense_Mutation | c.3385A>C | p.Lys1129Gln | p.K1129Q | Q9P2D6 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM135A | SNV | Missense_Mutation | c.439N>A | p.Gly147Ser | p.G147S | Q9P2D6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
FAM135A | SNV | Missense_Mutation | novel | c.1588N>A | p.Ala530Thr | p.A530T | Q9P2D6 | protein_coding | tolerated(0.3) | benign(0.005) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
FAM135A | SNV | Missense_Mutation | novel | c.1822N>A | p.Leu608Ile | p.L608I | Q9P2D6 | protein_coding | tolerated(0.25) | benign(0.15) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
FAM135A | SNV | Missense_Mutation | rs763568587 | c.712N>C | p.Tyr238His | p.Y238H | Q9P2D6 | protein_coding | tolerated(0.3) | benign(0.01) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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