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Gene: FAM127B |
Gene summary for FAM127B |
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Gene information | Species | Human | Gene symbol | FAM127B | Gene ID | 26071 |
Gene name | retrotransposon Gag like 8A | |
Gene Alias | CXX1b | |
Cytomap | Xq26.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BWD3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26071 | FAM127B | LZE4T | Human | Esophagus | ESCC | 4.49e-02 | -2.42e-01 | 0.0811 |
26071 | FAM127B | LZE24T | Human | Esophagus | ESCC | 6.32e-04 | -2.42e-01 | 0.0596 |
26071 | FAM127B | P1T-E | Human | Esophagus | ESCC | 1.47e-17 | 1.63e+00 | 0.0875 |
26071 | FAM127B | P2T-E | Human | Esophagus | ESCC | 9.80e-59 | 1.13e+00 | 0.1177 |
26071 | FAM127B | P4T-E | Human | Esophagus | ESCC | 8.00e-58 | 1.47e+00 | 0.1323 |
26071 | FAM127B | P5T-E | Human | Esophagus | ESCC | 2.85e-43 | 7.79e-01 | 0.1327 |
26071 | FAM127B | P8T-E | Human | Esophagus | ESCC | 2.17e-58 | 1.22e+00 | 0.0889 |
26071 | FAM127B | P9T-E | Human | Esophagus | ESCC | 1.47e-63 | 1.70e+00 | 0.1131 |
26071 | FAM127B | P10T-E | Human | Esophagus | ESCC | 1.09e-93 | 1.68e+00 | 0.116 |
26071 | FAM127B | P11T-E | Human | Esophagus | ESCC | 2.40e-32 | 1.40e+00 | 0.1426 |
26071 | FAM127B | P12T-E | Human | Esophagus | ESCC | 2.59e-88 | 1.84e+00 | 0.1122 |
26071 | FAM127B | P15T-E | Human | Esophagus | ESCC | 4.96e-24 | 8.05e-01 | 0.1149 |
26071 | FAM127B | P16T-E | Human | Esophagus | ESCC | 5.64e-39 | 6.40e-01 | 0.1153 |
26071 | FAM127B | P17T-E | Human | Esophagus | ESCC | 6.12e-20 | 9.07e-01 | 0.1278 |
26071 | FAM127B | P19T-E | Human | Esophagus | ESCC | 1.60e-16 | 1.86e+00 | 0.1662 |
26071 | FAM127B | P20T-E | Human | Esophagus | ESCC | 4.44e-40 | 1.19e+00 | 0.1124 |
26071 | FAM127B | P21T-E | Human | Esophagus | ESCC | 5.16e-102 | 1.90e+00 | 0.1617 |
26071 | FAM127B | P22T-E | Human | Esophagus | ESCC | 1.80e-137 | 2.81e+00 | 0.1236 |
26071 | FAM127B | P23T-E | Human | Esophagus | ESCC | 9.65e-67 | 2.07e+00 | 0.108 |
26071 | FAM127B | P24T-E | Human | Esophagus | ESCC | 2.68e-60 | 1.27e+00 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM127B | SNV | Missense_Mutation | c.29C>A | p.Ala10Asp | p.A10D | Q9BWD3 | protein_coding | deleterious(0) | benign(0.147) | TCGA-EI-6506-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM127B | SNV | Missense_Mutation | novel | c.98T>C | p.Phe33Ser | p.F33S | Q9BWD3 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM127B | SNV | Missense_Mutation | c.91N>A | p.Glu31Lys | p.E31K | Q9BWD3 | protein_coding | deleterious(0.03) | benign(0.061) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
FAM127B | SNV | Missense_Mutation | c.65G>A | p.Arg22His | p.R22H | Q9BWD3 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM127B | SNV | Missense_Mutation | rs778135155 | c.181G>A | p.Asp61Asn | p.D61N | Q9BWD3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM127B | SNV | Missense_Mutation | c.24N>A | p.Met8Ile | p.M8I | Q9BWD3 | protein_coding | tolerated(1) | benign(0) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM127B | SNV | Missense_Mutation | c.300N>T | p.Glu100Asp | p.E100D | Q9BWD3 | protein_coding | tolerated(0.07) | benign(0.014) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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