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Gene: FAF1 |
Gene summary for FAF1 |
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Gene information | Species | Human | Gene symbol | FAF1 | Gene ID | 11124 |
Gene name | Fas associated factor 1 | |
Gene Alias | CGI-03 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UNN5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11124 | FAF1 | CCI_1 | Human | Cervix | CC | 9.08e-31 | 2.03e+00 | 0.528 |
11124 | FAF1 | CCI_2 | Human | Cervix | CC | 2.28e-16 | 1.80e+00 | 0.5249 |
11124 | FAF1 | CCI_3 | Human | Cervix | CC | 1.73e-33 | 2.07e+00 | 0.516 |
11124 | FAF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.35e-22 | -5.96e-01 | 0.0155 |
11124 | FAF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.18e-11 | 6.24e-01 | -0.1954 |
11124 | FAF1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.60e-04 | 3.55e-01 | -0.2602 |
11124 | FAF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.84e-03 | -4.90e-01 | -0.1207 |
11124 | FAF1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.90e-07 | -6.73e-01 | -0.2061 |
11124 | FAF1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.50e-03 | -4.75e-01 | -0.1462 |
11124 | FAF1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.79e-02 | -3.36e-01 | -0.00410000000000005 |
11124 | FAF1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.01e-05 | -5.15e-01 | -0.0179 |
11124 | FAF1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.14e-18 | -5.55e-01 | 0.096 |
11124 | FAF1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.06e-03 | -6.34e-01 | 0.0451 |
11124 | FAF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.76e-08 | -4.00e-01 | 0.294 |
11124 | FAF1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.38e-05 | 6.66e-01 | 0.3487 |
11124 | FAF1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.52e-04 | -6.45e-01 | 0.2585 |
11124 | FAF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.94e-13 | -5.29e-01 | 0.3005 |
11124 | FAF1 | F007 | Human | Colorectum | FAP | 3.06e-02 | -2.96e-01 | 0.1176 |
11124 | FAF1 | A001-C-207 | Human | Colorectum | FAP | 4.00e-06 | -3.96e-01 | 0.1278 |
11124 | FAF1 | A015-C-203 | Human | Colorectum | FAP | 2.95e-37 | -6.66e-01 | -0.1294 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:190336410 | Cervix | CC | positive regulation of cellular protein catabolic process | 43/2311 | 155/18723 | 1.80e-07 | 8.28e-06 | 43 |
GO:20012357 | Cervix | CC | positive regulation of apoptotic signaling pathway | 37/2311 | 126/18723 | 2.70e-07 | 1.12e-05 | 37 |
GO:009719110 | Cervix | CC | extrinsic apoptotic signaling pathway | 52/2311 | 219/18723 | 2.06e-06 | 6.34e-05 | 52 |
GO:003133410 | Cervix | CC | positive regulation of protein-containing complex assembly | 55/2311 | 237/18723 | 2.25e-06 | 6.73e-05 | 55 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:200123610 | Cervix | CC | regulation of extrinsic apoptotic signaling pathway | 37/2311 | 151/18723 | 2.80e-05 | 4.65e-04 | 37 |
GO:004518510 | Cervix | CC | maintenance of protein location | 26/2311 | 94/18723 | 4.85e-05 | 7.34e-04 | 26 |
GO:20012386 | Cervix | CC | positive regulation of extrinsic apoptotic signaling pathway | 14/2311 | 48/18723 | 1.48e-03 | 1.15e-02 | 14 |
GO:00457404 | Cervix | CC | positive regulation of DNA replication | 12/2311 | 40/18723 | 2.44e-03 | 1.71e-02 | 12 |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAF1 | SNV | Missense_Mutation | rs370024425 | c.1334N>T | p.Thr445Met | p.T445M | Q9UNN5 | protein_coding | deleterious(0.04) | possibly_damaging(0.648) | TCGA-CM-5349-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAF1 | SNV | Missense_Mutation | c.74N>G | p.Glu25Gly | p.E25G | Q9UNN5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | rs538524843 | c.824N>A | p.Arg275Gln | p.R275Q | Q9UNN5 | protein_coding | tolerated(0.55) | benign(0.001) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAF1 | SNV | Missense_Mutation | c.664A>G | p.Arg222Gly | p.R222G | Q9UNN5 | protein_coding | tolerated(0.09) | possibly_damaging(0.549) | TCGA-G4-6627-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAF1 | SNV | Missense_Mutation | rs371330134 | c.938C>T | p.Ala313Val | p.A313V | Q9UNN5 | protein_coding | tolerated(0.3) | benign(0.039) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAF1 | deletion | Frame_Shift_Del | c.257delN | p.Pro86LeufsTer2 | p.P86Lfs*2 | Q9UNN5 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
FAF1 | insertion | Frame_Shift_Ins | novel | c.190_191insATTTCTGTCT | p.Pro64HisfsTer7 | p.P64Hfs*7 | Q9UNN5 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FAF1 | SNV | Missense_Mutation | novel | c.1762N>T | p.Arg588Trp | p.R588W | Q9UNN5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAF1 | SNV | Missense_Mutation | novel | c.973N>A | p.Glu325Lys | p.E325K | Q9UNN5 | protein_coding | deleterious(0.02) | possibly_damaging(0.815) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAF1 | SNV | Missense_Mutation | rs747000653 | c.739N>A | p.Asp247Asn | p.D247N | Q9UNN5 | protein_coding | tolerated(0.09) | benign(0.397) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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