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Gene: FAAP24 |
Gene summary for FAAP24 |
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Gene information | Species | Human | Gene symbol | FAAP24 | Gene ID | 91442 |
Gene name | FA core complex associated protein 24 | |
Gene Alias | C19orf40 | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | K7EKQ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91442 | FAAP24 | HCC1_Meng | Human | Liver | HCC | 3.99e-09 | -5.91e-03 | 0.0246 |
91442 | FAAP24 | HCC1 | Human | Liver | HCC | 3.62e-08 | 1.60e+00 | 0.5336 |
91442 | FAAP24 | HCC2 | Human | Liver | HCC | 1.55e-14 | 1.01e+00 | 0.5341 |
91442 | FAAP24 | HCC5 | Human | Liver | HCC | 1.92e-18 | 1.02e+00 | 0.4932 |
91442 | FAAP24 | S016 | Human | Liver | HCC | 3.08e-02 | 1.20e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAAP24 | SNV | Missense_Mutation | novel | c.280A>G | p.Thr94Ala | p.T94A | Q9BTP7 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAAP24 | SNV | Missense_Mutation | novel | c.385G>A | p.Val129Ile | p.V129I | Q9BTP7 | protein_coding | tolerated(1) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAAP24 | SNV | Missense_Mutation | novel | c.568N>A | p.Ala190Thr | p.A190T | Q9BTP7 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAAP24 | SNV | Missense_Mutation | rs765341488 | c.232N>T | p.Arg78Trp | p.R78W | Q9BTP7 | protein_coding | deleterious(0) | benign(0.024) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAAP24 | SNV | Missense_Mutation | novel | c.227N>G | p.Leu76Arg | p.L76R | Q9BTP7 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAAP24 | SNV | Missense_Mutation | novel | c.366G>C | p.Gln122His | p.Q122H | Q9BTP7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EY-A1GS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
FAAP24 | SNV | Missense_Mutation | novel | c.326T>C | p.Val109Ala | p.V109A | Q9BTP7 | protein_coding | deleterious(0.03) | possibly_damaging(0.822) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAAP24 | SNV | Missense_Mutation | rs555157808 | c.283N>T | p.Arg95Trp | p.R95W | Q9BTP7 | protein_coding | tolerated(0.06) | benign(0.131) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAAP24 | deletion | Frame_Shift_Del | novel | c.207delN | p.Asn70MetfsTer20 | p.N70Mfs*20 | Q9BTP7 | protein_coding | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
FAAP24 | insertion | Frame_Shift_Ins | novel | c.274_275insA | p.Thr94AsnfsTer5 | p.T94Nfs*5 | Q9BTP7 | protein_coding | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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