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Gene: EXOSC9 |
Gene summary for EXOSC9 |
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Gene information | Species | Human | Gene symbol | EXOSC9 | Gene ID | 5393 |
Gene name | exosome component 9 | |
Gene Alias | PCH1D | |
Cytomap | 4q27 | |
Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | Q06265 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5393 | EXOSC9 | LZE5T | Human | Esophagus | ESCC | 8.65e-04 | 2.12e-01 | 0.0514 |
5393 | EXOSC9 | LZE7T | Human | Esophagus | ESCC | 5.14e-05 | 1.63e-01 | 0.0667 |
5393 | EXOSC9 | LZE24T | Human | Esophagus | ESCC | 1.57e-03 | 9.55e-02 | 0.0596 |
5393 | EXOSC9 | LZE21T | Human | Esophagus | ESCC | 1.65e-04 | 4.21e-01 | 0.0655 |
5393 | EXOSC9 | P1T-E | Human | Esophagus | ESCC | 2.22e-06 | 1.91e-01 | 0.0875 |
5393 | EXOSC9 | P2T-E | Human | Esophagus | ESCC | 3.05e-25 | 5.11e-01 | 0.1177 |
5393 | EXOSC9 | P4T-E | Human | Esophagus | ESCC | 1.19e-15 | 3.52e-01 | 0.1323 |
5393 | EXOSC9 | P5T-E | Human | Esophagus | ESCC | 7.04e-21 | 2.71e-01 | 0.1327 |
5393 | EXOSC9 | P8T-E | Human | Esophagus | ESCC | 2.15e-05 | 1.99e-01 | 0.0889 |
5393 | EXOSC9 | P9T-E | Human | Esophagus | ESCC | 1.40e-06 | 1.27e-01 | 0.1131 |
5393 | EXOSC9 | P10T-E | Human | Esophagus | ESCC | 4.78e-10 | 1.76e-01 | 0.116 |
5393 | EXOSC9 | P11T-E | Human | Esophagus | ESCC | 1.28e-09 | 3.85e-01 | 0.1426 |
5393 | EXOSC9 | P12T-E | Human | Esophagus | ESCC | 4.73e-25 | 5.07e-01 | 0.1122 |
5393 | EXOSC9 | P15T-E | Human | Esophagus | ESCC | 1.05e-10 | 1.95e-01 | 0.1149 |
5393 | EXOSC9 | P16T-E | Human | Esophagus | ESCC | 1.14e-13 | 3.20e-01 | 0.1153 |
5393 | EXOSC9 | P17T-E | Human | Esophagus | ESCC | 1.28e-04 | 2.01e-01 | 0.1278 |
5393 | EXOSC9 | P19T-E | Human | Esophagus | ESCC | 1.04e-02 | 3.37e-01 | 0.1662 |
5393 | EXOSC9 | P20T-E | Human | Esophagus | ESCC | 2.13e-08 | 1.40e-01 | 0.1124 |
5393 | EXOSC9 | P21T-E | Human | Esophagus | ESCC | 3.93e-09 | 2.71e-01 | 0.1617 |
5393 | EXOSC9 | P22T-E | Human | Esophagus | ESCC | 8.23e-28 | 5.61e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:0006401110 | Esophagus | ESCC | RNA catabolic process | 204/8552 | 278/18723 | 3.39e-21 | 5.66e-19 | 204 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:0006402110 | Esophagus | ESCC | mRNA catabolic process | 170/8552 | 232/18723 | 8.70e-18 | 8.00e-16 | 170 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:000095618 | Esophagus | ESCC | nuclear-transcribed mRNA catabolic process | 88/8552 | 112/18723 | 9.41e-13 | 4.14e-11 | 88 |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301824 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa0301834 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa030189 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301814 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EXOSC9 | SNV | Missense_Mutation | c.557N>A | p.Ser186Asn | p.S186N | Q06265 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-CM-6169-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Ancillary | leucovorin | SD | |
EXOSC9 | SNV | Missense_Mutation | c.1264N>C | p.Asp422His | p.D422H | Q06265 | protein_coding | tolerated_low_confidence(0.06) | benign(0.444) | TCGA-AG-A011-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EXOSC9 | SNV | Missense_Mutation | rs761262917 | c.271G>A | p.Glu91Lys | p.E91K | Q06265 | protein_coding | deleterious(0) | possibly_damaging(0.838) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
EXOSC9 | SNV | Missense_Mutation | c.60G>T | p.Glu20Asp | p.E20D | Q06265 | protein_coding | tolerated(0.12) | benign(0.036) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EXOSC9 | SNV | Missense_Mutation | novel | c.1248G>T | p.Met416Ile | p.M416I | Q06265 | protein_coding | tolerated_low_confidence(0.09) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EXOSC9 | insertion | In_Frame_Ins | novel | c.1117_1118insTAT | p.Met373delinsIleLeu | p.M373delinsIL | Q06265 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EXOSC9 | insertion | In_Frame_Ins | novel | c.1119_1120insCTATTTGAT | p.Met373_Asp374insLeuPheAsp | p.M373_D374insLFD | Q06265 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EXOSC9 | SNV | Missense_Mutation | c.733G>T | p.Asp245Tyr | p.D245Y | Q06265 | protein_coding | deleterious(0) | benign(0.114) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
EXOSC9 | SNV | Missense_Mutation | novel | c.822A>C | p.Lys274Asn | p.K274N | Q06265 | protein_coding | tolerated(0.13) | benign(0.014) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EXOSC9 | SNV | Missense_Mutation | rs776925374 | c.635G>A | p.Arg212Gln | p.R212Q | Q06265 | protein_coding | tolerated(0.21) | benign(0.006) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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