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Gene: EXOC6 |
Gene summary for EXOC6 |
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Gene information | Species | Human | Gene symbol | EXOC6 | Gene ID | 54536 |
Gene name | exocyst complex component 6 | |
Gene Alias | EXOC6A | |
Cytomap | 10q23.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B3KXY5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54536 | EXOC6 | NAFLD1 | Human | Liver | NAFLD | 1.80e-03 | 3.49e-01 | -0.04 |
54536 | EXOC6 | HCC1_Meng | Human | Liver | HCC | 1.44e-58 | -4.65e-02 | 0.0246 |
54536 | EXOC6 | HCC2_Meng | Human | Liver | HCC | 1.12e-13 | -1.31e-02 | 0.0107 |
54536 | EXOC6 | HCC1 | Human | Liver | HCC | 8.04e-03 | 3.35e+00 | 0.5336 |
54536 | EXOC6 | HCC2 | Human | Liver | HCC | 9.11e-05 | 2.96e+00 | 0.5341 |
54536 | EXOC6 | Pt14.a | Human | Liver | HCC | 4.10e-04 | 2.25e-01 | 0.0169 |
54536 | EXOC6 | S027 | Human | Liver | HCC | 1.76e-02 | 3.79e-01 | 0.2446 |
54536 | EXOC6 | S028 | Human | Liver | HCC | 3.83e-03 | 3.67e-01 | 0.2503 |
54536 | EXOC6 | S029 | Human | Liver | HCC | 1.66e-04 | 4.43e-01 | 0.2581 |
54536 | EXOC6 | HTA12-23-1 | Human | Pancreas | PDAC | 8.22e-04 | 7.78e-01 | 0.3405 |
54536 | EXOC6 | HTA12-25-1 | Human | Pancreas | PDAC | 2.31e-12 | 1.04e+00 | 0.313 |
54536 | EXOC6 | HTA12-26-1 | Human | Pancreas | PDAC | 1.11e-21 | 1.08e+00 | 0.3728 |
54536 | EXOC6 | HTA12-29-1 | Human | Pancreas | PDAC | 9.74e-63 | 1.26e+00 | 0.3722 |
54536 | EXOC6 | HTA12-32-1 | Human | Pancreas | PDAC | 1.27e-06 | 1.34e+00 | 0.3624 |
54536 | EXOC6 | male-WTA | Human | Thyroid | PTC | 6.89e-26 | 1.21e-01 | 0.1037 |
54536 | EXOC6 | PTC01 | Human | Thyroid | PTC | 1.90e-12 | 2.32e-01 | 0.1899 |
54536 | EXOC6 | PTC04 | Human | Thyroid | PTC | 5.49e-24 | 4.75e-01 | 0.1927 |
54536 | EXOC6 | PTC05 | Human | Thyroid | PTC | 1.60e-23 | 8.44e-01 | 0.2065 |
54536 | EXOC6 | PTC06 | Human | Thyroid | PTC | 8.80e-31 | 6.57e-01 | 0.2057 |
54536 | EXOC6 | PTC07 | Human | Thyroid | PTC | 5.43e-39 | 6.35e-01 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00516567 | Cervix | CC | establishment of organelle localization | 76/2311 | 390/18723 | 3.17e-05 | 5.21e-04 | 76 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00068927 | Cervix | CC | post-Golgi vesicle-mediated transport | 28/2311 | 104/18723 | 4.31e-05 | 6.61e-04 | 28 |
GO:00481938 | Cervix | CC | Golgi vesicle transport | 58/2311 | 296/18723 | 2.24e-04 | 2.54e-03 | 58 |
GO:00068936 | Cervix | CC | Golgi to plasma membrane transport | 16/2311 | 60/18723 | 2.00e-03 | 1.46e-02 | 16 |
GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
GO:0051650 | Colorectum | AD | establishment of vesicle localization | 57/3918 | 161/18723 | 1.47e-05 | 3.15e-04 | 57 |
GO:0006893 | Colorectum | AD | Golgi to plasma membrane transport | 27/3918 | 60/18723 | 2.41e-05 | 4.66e-04 | 27 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0006903 | Colorectum | AD | vesicle targeting | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00068921 | Colorectum | SER | post-Golgi vesicle-mediated transport | 31/2897 | 104/18723 | 1.59e-04 | 3.08e-03 | 31 |
GO:00988761 | Colorectum | SER | vesicle-mediated transport to the plasma membrane | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00516501 | Colorectum | SER | establishment of vesicle localization | 42/2897 | 161/18723 | 3.38e-04 | 5.35e-03 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EXOC6 | SNV | Missense_Mutation | c.2304N>C | p.Lys768Asn | p.K768N | Q8TAG9 | protein_coding | deleterious(0.02) | probably_damaging(0.937) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
EXOC6 | SNV | Missense_Mutation | rs752268240 | c.1445N>T | p.Ser482Phe | p.S482F | Q8TAG9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EXOC6 | SNV | Missense_Mutation | c.1993N>T | p.His665Tyr | p.H665Y | Q8TAG9 | protein_coding | tolerated(0.06) | possibly_damaging(0.773) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EXOC6 | SNV | Missense_Mutation | c.424N>A | p.Tyr142Asn | p.Y142N | Q8TAG9 | protein_coding | deleterious(0) | possibly_damaging(0.655) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EXOC6 | SNV | Missense_Mutation | rs566672685 | c.743G>A | p.Arg248His | p.R248H | Q8TAG9 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-AA-3989-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
EXOC6 | SNV | Missense_Mutation | novel | c.1657N>C | p.Asn553His | p.N553H | Q8TAG9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EXOC6 | SNV | Missense_Mutation | c.1964N>T | p.Ala655Val | p.A655V | Q8TAG9 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EXOC6 | SNV | Missense_Mutation | c.1921N>G | p.Arg641Gly | p.R641G | Q8TAG9 | protein_coding | deleterious(0.04) | benign(0.405) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
EXOC6 | SNV | Missense_Mutation | c.586T>A | p.Ser196Thr | p.S196T | Q8TAG9 | protein_coding | deleterious(0) | benign(0.142) | TCGA-AA-A029-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EXOC6 | SNV | Missense_Mutation | c.623N>A | p.Arg208Gln | p.R208Q | Q8TAG9 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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