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Gene: ESRP2 |
Gene summary for ESRP2 |
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Gene information | Species | Human | Gene symbol | ESRP2 | Gene ID | 80004 |
Gene name | epithelial splicing regulatory protein 2 | |
Gene Alias | RBM35B | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q9H6T0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80004 | ESRP2 | LZE4T | Human | Esophagus | ESCC | 1.04e-04 | 2.15e-01 | 0.0811 |
80004 | ESRP2 | LZE7T | Human | Esophagus | ESCC | 4.75e-03 | 1.86e-01 | 0.0667 |
80004 | ESRP2 | LZE24T | Human | Esophagus | ESCC | 9.81e-13 | 3.63e-01 | 0.0596 |
80004 | ESRP2 | P1T-E | Human | Esophagus | ESCC | 7.12e-12 | 4.80e-01 | 0.0875 |
80004 | ESRP2 | P2T-E | Human | Esophagus | ESCC | 8.15e-05 | 1.01e-01 | 0.1177 |
80004 | ESRP2 | P4T-E | Human | Esophagus | ESCC | 1.13e-08 | 2.33e-01 | 0.1323 |
80004 | ESRP2 | P5T-E | Human | Esophagus | ESCC | 2.90e-07 | 1.33e-01 | 0.1327 |
80004 | ESRP2 | P8T-E | Human | Esophagus | ESCC | 8.09e-30 | 5.78e-01 | 0.0889 |
80004 | ESRP2 | P10T-E | Human | Esophagus | ESCC | 1.72e-02 | 1.68e-02 | 0.116 |
80004 | ESRP2 | P12T-E | Human | Esophagus | ESCC | 4.15e-15 | 2.67e-01 | 0.1122 |
80004 | ESRP2 | P15T-E | Human | Esophagus | ESCC | 3.57e-05 | 1.57e-01 | 0.1149 |
80004 | ESRP2 | P16T-E | Human | Esophagus | ESCC | 4.26e-03 | 1.94e-02 | 0.1153 |
80004 | ESRP2 | P20T-E | Human | Esophagus | ESCC | 5.24e-13 | 3.28e-01 | 0.1124 |
80004 | ESRP2 | P21T-E | Human | Esophagus | ESCC | 4.04e-02 | 1.37e-01 | 0.1617 |
80004 | ESRP2 | P22T-E | Human | Esophagus | ESCC | 1.80e-07 | 1.36e-01 | 0.1236 |
80004 | ESRP2 | P23T-E | Human | Esophagus | ESCC | 2.09e-25 | 6.37e-01 | 0.108 |
80004 | ESRP2 | P24T-E | Human | Esophagus | ESCC | 4.60e-06 | 1.46e-01 | 0.1287 |
80004 | ESRP2 | P26T-E | Human | Esophagus | ESCC | 1.99e-14 | 3.88e-01 | 0.1276 |
80004 | ESRP2 | P27T-E | Human | Esophagus | ESCC | 6.42e-09 | 2.36e-01 | 0.1055 |
80004 | ESRP2 | P28T-E | Human | Esophagus | ESCC | 2.20e-22 | 4.38e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:000038019 | Esophagus | ESCC | alternative mRNA splicing, via spliceosome | 55/8552 | 77/18723 | 4.07e-06 | 4.38e-05 | 55 |
GO:002261216 | Esophagus | ESCC | gland morphogenesis | 78/8552 | 118/18723 | 5.83e-06 | 6.03e-05 | 78 |
GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
GO:006056210 | Esophagus | ESCC | epithelial tube morphogenesis | 187/8552 | 325/18723 | 9.95e-06 | 9.44e-05 | 187 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
GO:00303249 | Esophagus | ESCC | lung development | 109/8552 | 177/18723 | 1.40e-05 | 1.27e-04 | 109 |
GO:00604257 | Esophagus | ESCC | lung morphogenesis | 37/8552 | 50/18723 | 4.42e-05 | 3.51e-04 | 37 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:005067817 | Esophagus | ESCC | regulation of epithelial cell proliferation | 206/8552 | 381/18723 | 5.51e-04 | 3.02e-03 | 206 |
GO:00604414 | Esophagus | ESCC | epithelial tube branching involved in lung morphogenesis | 22/8552 | 29/18723 | 9.30e-04 | 4.73e-03 | 22 |
GO:00017639 | Esophagus | ESCC | morphogenesis of a branching structure | 106/8552 | 196/18723 | 1.08e-02 | 3.66e-02 | 106 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ESRP2 | SNV | Missense_Mutation | c.987N>T | p.Lys329Asn | p.K329N | Q9H6T0 | protein_coding | tolerated(0.16) | benign(0.236) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ESRP2 | SNV | Missense_Mutation | rs763741902 | c.1073C>T | p.Ser358Leu | p.S358L | Q9H6T0 | protein_coding | deleterious(0.05) | benign(0.145) | TCGA-AZ-4682-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | camptosar | PD |
ESRP2 | SNV | Missense_Mutation | rs748645452 | c.794G>A | p.Arg265His | p.R265H | Q9H6T0 | protein_coding | deleterious(0) | possibly_damaging(0.576) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ESRP2 | SNV | Missense_Mutation | novel | c.1495N>G | p.Met499Val | p.M499V | Q9H6T0 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ESRP2 | SNV | Missense_Mutation | c.1786C>A | p.Pro596Thr | p.P596T | Q9H6T0 | protein_coding | tolerated(0.07) | possibly_damaging(0.543) | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
ESRP2 | SNV | Missense_Mutation | novel | c.1426N>A | p.Ala476Thr | p.A476T | Q9H6T0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ESRP2 | SNV | Missense_Mutation | novel | c.508N>T | p.Pro170Ser | p.P170S | Q9H6T0 | protein_coding | tolerated(0.17) | benign(0.038) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ESRP2 | SNV | Missense_Mutation | novel | c.414N>T | p.Gln138His | p.Q138H | Q9H6T0 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ESRP2 | SNV | Missense_Mutation | novel | c.1426N>A | p.Ala476Thr | p.A476T | Q9H6T0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ESRP2 | SNV | Missense_Mutation | rs763528773 | c.881N>A | p.Arg294His | p.R294H | Q9H6T0 | protein_coding | deleterious(0.02) | possibly_damaging(0.886) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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