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Gene: ERICH1 |
Gene summary for ERICH1 |
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Gene information | Species | Human | Gene symbol | ERICH1 | Gene ID | 157697 |
Gene name | glutamate rich 1 | |
Gene Alias | HSPC319 | |
Cytomap | 8p23.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | B4DMI5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
157697 | ERICH1 | LZE2T | Human | Esophagus | ESCC | 3.41e-04 | 4.11e-01 | 0.082 |
157697 | ERICH1 | LZE3D | Human | Esophagus | HGIN | 1.27e-03 | 5.74e-01 | 0.0668 |
157697 | ERICH1 | LZE4T | Human | Esophagus | ESCC | 3.03e-21 | 3.11e-01 | 0.0811 |
157697 | ERICH1 | LZE7T | Human | Esophagus | ESCC | 1.65e-06 | 3.58e-01 | 0.0667 |
157697 | ERICH1 | LZE8T | Human | Esophagus | ESCC | 1.70e-14 | 3.67e-01 | 0.067 |
157697 | ERICH1 | LZE20T | Human | Esophagus | ESCC | 7.56e-08 | 1.36e-01 | 0.0662 |
157697 | ERICH1 | LZE21D1 | Human | Esophagus | HGIN | 1.12e-05 | 3.22e-01 | 0.0632 |
157697 | ERICH1 | LZE22D1 | Human | Esophagus | HGIN | 1.26e-02 | 1.16e-01 | 0.0595 |
157697 | ERICH1 | LZE22T | Human | Esophagus | ESCC | 1.69e-04 | 2.32e-01 | 0.068 |
157697 | ERICH1 | LZE24T | Human | Esophagus | ESCC | 2.47e-19 | 4.94e-01 | 0.0596 |
157697 | ERICH1 | LZE21T | Human | Esophagus | ESCC | 4.21e-11 | 4.44e-01 | 0.0655 |
157697 | ERICH1 | LZE6T | Human | Esophagus | ESCC | 9.82e-10 | 3.07e-01 | 0.0845 |
157697 | ERICH1 | P1T-E | Human | Esophagus | ESCC | 3.33e-22 | 5.10e-01 | 0.0875 |
157697 | ERICH1 | P2T-E | Human | Esophagus | ESCC | 4.03e-21 | 3.21e-01 | 0.1177 |
157697 | ERICH1 | P4T-E | Human | Esophagus | ESCC | 8.55e-50 | 9.41e-01 | 0.1323 |
157697 | ERICH1 | P5T-E | Human | Esophagus | ESCC | 1.22e-19 | 3.68e-01 | 0.1327 |
157697 | ERICH1 | P8T-E | Human | Esophagus | ESCC | 2.67e-28 | 5.94e-01 | 0.0889 |
157697 | ERICH1 | P9T-E | Human | Esophagus | ESCC | 3.18e-29 | 4.64e-01 | 0.1131 |
157697 | ERICH1 | P10T-E | Human | Esophagus | ESCC | 1.96e-49 | 8.17e-01 | 0.116 |
157697 | ERICH1 | P11T-E | Human | Esophagus | ESCC | 5.99e-15 | 2.85e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERICH1 | insertion | Frame_Shift_Ins | novel | c.366dupA | p.Phe123IlefsTer2 | p.F123Ifs*2 | Q86X53 | protein_coding | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
ERICH1 | deletion | Frame_Shift_Del | c.487delA | p.Arg163GlyfsTer3 | p.R163Gfs*3 | Q86X53 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
ERICH1 | SNV | Missense_Mutation | novel | c.1133C>T | p.Ser378Leu | p.S378L | Q86X53 | protein_coding | deleterious(0) | benign(0.31) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ERICH1 | SNV | Missense_Mutation | novel | c.1016G>T | p.Ser339Ile | p.S339I | Q86X53 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ERICH1 | SNV | Missense_Mutation | c.373N>G | p.Asn125Asp | p.N125D | Q86X53 | protein_coding | tolerated(0.09) | benign(0.111) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
ERICH1 | SNV | Missense_Mutation | c.601N>T | p.Gly201Cys | p.G201C | Q86X53 | protein_coding | deleterious(0.02) | possibly_damaging(0.752) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ERICH1 | SNV | Missense_Mutation | novel | c.421N>G | p.Ser141Gly | p.S141G | Q86X53 | protein_coding | tolerated(0.13) | possibly_damaging(0.559) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ERICH1 | SNV | Missense_Mutation | rs762087184 | c.824N>A | p.Val275Glu | p.V275E | Q86X53 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ERICH1 | SNV | Missense_Mutation | rs369345572 | c.653N>T | p.Pro218Leu | p.P218L | Q86X53 | protein_coding | tolerated(0.61) | benign(0) | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ERICH1 | SNV | Missense_Mutation | rs776402342 | c.776N>T | p.Thr259Ile | p.T259I | Q86X53 | protein_coding | tolerated_low_confidence(0.32) | benign(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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