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Gene: ERF |
Gene summary for ERF |
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Gene information | Species | Human | Gene symbol | ERF | Gene ID | 2077 |
Gene name | ETS2 repressor factor | |
Gene Alias | CHYTS | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P50548 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2077 | ERF | S43 | Human | Liver | Cirrhotic | 2.30e-06 | -2.22e-01 | -0.0187 |
2077 | ERF | HCC1_Meng | Human | Liver | HCC | 3.60e-53 | -5.39e-02 | 0.0246 |
2077 | ERF | HCC2_Meng | Human | Liver | HCC | 3.91e-11 | -8.56e-02 | 0.0107 |
2077 | ERF | cirrhotic1 | Human | Liver | Cirrhotic | 7.07e-06 | 1.07e-01 | 0.0202 |
2077 | ERF | cirrhotic2 | Human | Liver | Cirrhotic | 6.28e-04 | 3.11e-02 | 0.0201 |
2077 | ERF | Pt13.b | Human | Liver | HCC | 7.22e-05 | -1.65e-02 | 0.0251 |
2077 | ERF | S014 | Human | Liver | HCC | 3.88e-15 | 7.21e-01 | 0.2254 |
2077 | ERF | S015 | Human | Liver | HCC | 1.11e-15 | 8.51e-01 | 0.2375 |
2077 | ERF | S016 | Human | Liver | HCC | 9.70e-12 | 5.70e-01 | 0.2243 |
2077 | ERF | S028 | Human | Liver | HCC | 1.06e-04 | 3.79e-01 | 0.2503 |
2077 | ERF | C04 | Human | Oral cavity | OSCC | 1.93e-08 | 8.16e-01 | 0.2633 |
2077 | ERF | C21 | Human | Oral cavity | OSCC | 8.56e-06 | 3.56e-01 | 0.2678 |
2077 | ERF | C30 | Human | Oral cavity | OSCC | 1.09e-32 | 1.48e+00 | 0.3055 |
2077 | ERF | C38 | Human | Oral cavity | OSCC | 5.00e-06 | 1.14e+00 | 0.172 |
2077 | ERF | C43 | Human | Oral cavity | OSCC | 3.70e-18 | 4.47e-01 | 0.1704 |
2077 | ERF | C51 | Human | Oral cavity | OSCC | 5.34e-04 | 4.64e-01 | 0.2674 |
2077 | ERF | C06 | Human | Oral cavity | OSCC | 2.38e-04 | 1.28e+00 | 0.2699 |
2077 | ERF | C08 | Human | Oral cavity | OSCC | 3.61e-25 | 6.17e-01 | 0.1919 |
2077 | ERF | C09 | Human | Oral cavity | OSCC | 2.70e-24 | 1.18e+00 | 0.1431 |
2077 | ERF | LN46 | Human | Oral cavity | OSCC | 9.67e-06 | 6.54e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00316479 | Breast | Precancer | regulation of protein stability | 38/1080 | 298/18723 | 3.73e-06 | 1.19e-04 | 38 |
GO:003164714 | Breast | IDC | regulation of protein stability | 50/1434 | 298/18723 | 1.14e-07 | 6.57e-06 | 50 |
GO:003164724 | Breast | DCIS | regulation of protein stability | 51/1390 | 298/18723 | 1.63e-08 | 1.15e-06 | 51 |
GO:004854510 | Cervix | CC | response to steroid hormone | 74/2311 | 339/18723 | 5.71e-07 | 2.09e-05 | 74 |
GO:00305229 | Cervix | CC | intracellular receptor signaling pathway | 60/2311 | 265/18723 | 1.89e-06 | 5.97e-05 | 60 |
GO:003164710 | Cervix | CC | regulation of protein stability | 63/2311 | 298/18723 | 1.14e-05 | 2.45e-04 | 63 |
GO:190165410 | Cervix | CC | response to ketone | 45/2311 | 194/18723 | 1.83e-05 | 3.44e-04 | 45 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00325704 | Cervix | CC | response to progesterone | 13/2311 | 37/18723 | 2.99e-04 | 3.21e-03 | 13 |
GO:00713839 | Cervix | CC | cellular response to steroid hormone stimulus | 40/2311 | 204/18723 | 1.93e-03 | 1.42e-02 | 40 |
GO:00305188 | Cervix | CC | intracellular steroid hormone receptor signaling pathway | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
GO:2000278 | Colorectum | AD | regulation of DNA biosynthetic process | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:0032206 | Colorectum | AD | positive regulation of telomere maintenance | 23/3918 | 52/18723 | 1.31e-04 | 1.88e-03 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERF | SNV | Missense_Mutation | novel | c.1570C>G | p.Pro524Ala | p.P524A | P50548 | protein_coding | tolerated_low_confidence(0.18) | benign(0.003) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ERF | SNV | Missense_Mutation | rs370521331 | c.209N>A | p.Arg70His | p.R70H | P50548 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ERF | SNV | Missense_Mutation | novel | c.160G>A | p.Glu54Lys | p.E54K | P50548 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ERF | SNV | Missense_Mutation | c.1259N>T | p.Pro420Leu | p.P420L | P50548 | protein_coding | deleterious_low_confidence(0.03) | benign(0.099) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ERF | SNV | Missense_Mutation | c.970N>A | p.Tyr324Asn | p.Y324N | P50548 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ERF | SNV | Missense_Mutation | rs769239795 | c.301N>T | p.Arg101Trp | p.R101W | P50548 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ERF | deletion | Frame_Shift_Del | rs780487406 | c.896delN | p.Gly299GlufsTer12 | p.G299Efs*12 | P50548 | protein_coding | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ERF | deletion | Frame_Shift_Del | c.719delN | p.Gly240ValfsTer31 | p.G240Vfs*31 | P50548 | protein_coding | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
ERF | deletion | Frame_Shift_Del | rs780487406 | c.896delN | p.Gly299GlufsTer12 | p.G299Efs*12 | P50548 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ERF | SNV | Missense_Mutation | rs768322408 | c.166N>A | p.Val56Ile | p.V56I | P50548 | protein_coding | deleterious(0) | possibly_damaging(0.576) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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