![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ERAP1 |
Gene summary for ERAP1 |
![]() |
Gene information | Species | Human | Gene symbol | ERAP1 | Gene ID | 51752 |
Gene name | endoplasmic reticulum aminopeptidase 1 | |
Gene Alias | A-LAP | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q9NZ08 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51752 | ERAP1 | LZE4T | Human | Esophagus | ESCC | 2.70e-04 | 5.59e-02 | 0.0811 |
51752 | ERAP1 | LZE8T | Human | Esophagus | ESCC | 8.81e-09 | 2.21e-01 | 0.067 |
51752 | ERAP1 | LZE24T | Human | Esophagus | ESCC | 5.04e-09 | 1.43e-01 | 0.0596 |
51752 | ERAP1 | P1T-E | Human | Esophagus | ESCC | 2.74e-04 | 1.26e-01 | 0.0875 |
51752 | ERAP1 | P2T-E | Human | Esophagus | ESCC | 9.86e-26 | 5.06e-01 | 0.1177 |
51752 | ERAP1 | P4T-E | Human | Esophagus | ESCC | 2.52e-04 | 8.05e-02 | 0.1323 |
51752 | ERAP1 | P8T-E | Human | Esophagus | ESCC | 1.66e-20 | 1.75e-01 | 0.0889 |
51752 | ERAP1 | P9T-E | Human | Esophagus | ESCC | 4.66e-05 | 5.96e-02 | 0.1131 |
51752 | ERAP1 | P10T-E | Human | Esophagus | ESCC | 1.99e-07 | -3.34e-03 | 0.116 |
51752 | ERAP1 | P11T-E | Human | Esophagus | ESCC | 3.19e-02 | 1.84e-01 | 0.1426 |
51752 | ERAP1 | P12T-E | Human | Esophagus | ESCC | 2.28e-14 | 1.57e-01 | 0.1122 |
51752 | ERAP1 | P15T-E | Human | Esophagus | ESCC | 2.92e-12 | 2.80e-01 | 0.1149 |
51752 | ERAP1 | P16T-E | Human | Esophagus | ESCC | 1.49e-04 | -2.52e-02 | 0.1153 |
51752 | ERAP1 | P17T-E | Human | Esophagus | ESCC | 7.60e-04 | 1.58e-01 | 0.1278 |
51752 | ERAP1 | P19T-E | Human | Esophagus | ESCC | 1.45e-02 | 3.09e-01 | 0.1662 |
51752 | ERAP1 | P20T-E | Human | Esophagus | ESCC | 3.49e-19 | 4.61e-01 | 0.1124 |
51752 | ERAP1 | P21T-E | Human | Esophagus | ESCC | 1.69e-12 | 9.89e-02 | 0.1617 |
51752 | ERAP1 | P22T-E | Human | Esophagus | ESCC | 1.60e-08 | 4.43e-02 | 0.1236 |
51752 | ERAP1 | P23T-E | Human | Esophagus | ESCC | 4.04e-16 | 2.08e-01 | 0.108 |
51752 | ERAP1 | P24T-E | Human | Esophagus | ESCC | 1.17e-11 | 1.58e-01 | 0.1287 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:004800220 | Esophagus | ESCC | antigen processing and presentation of peptide antigen | 44/8552 | 62/18723 | 4.81e-05 | 3.78e-04 | 44 |
GO:001988225 | Esophagus | ESCC | antigen processing and presentation | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:00450885 | Esophagus | ESCC | regulation of innate immune response | 125/8552 | 218/18723 | 3.34e-04 | 1.96e-03 | 125 |
GO:000247418 | Esophagus | ESCC | antigen processing and presentation of peptide antigen via MHC class I | 22/8552 | 28/18723 | 3.95e-04 | 2.26e-03 | 22 |
GO:00065095 | Esophagus | ESCC | membrane protein ectodomain proteolysis | 31/8552 | 43/18723 | 4.04e-04 | 2.30e-03 | 31 |
GO:00336195 | Esophagus | ESCC | membrane protein proteolysis | 39/8552 | 57/18723 | 4.34e-04 | 2.44e-03 | 39 |
GO:000248325 | Esophagus | ESCC | antigen processing and presentation of endogenous peptide antigen | 16/8552 | 19/18723 | 6.45e-04 | 3.43e-03 | 16 |
GO:001988519 | Esophagus | ESCC | antigen processing and presentation of endogenous peptide antigen via MHC class I | 14/8552 | 17/18723 | 2.22e-03 | 9.78e-03 | 14 |
GO:0019883111 | Esophagus | ESCC | antigen processing and presentation of endogenous antigen | 18/8552 | 26/18723 | 1.32e-02 | 4.31e-02 | 18 |
GO:00336192 | Liver | Cirrhotic | membrane protein proteolysis | 31/4634 | 57/18723 | 1.55e-06 | 3.02e-05 | 31 |
GO:00065092 | Liver | Cirrhotic | membrane protein ectodomain proteolysis | 24/4634 | 43/18723 | 1.30e-05 | 1.82e-04 | 24 |
GO:00198827 | Liver | Cirrhotic | antigen processing and presentation | 44/4634 | 106/18723 | 1.07e-04 | 1.10e-03 | 44 |
GO:00480027 | Liver | Cirrhotic | antigen processing and presentation of peptide antigen | 29/4634 | 62/18723 | 1.34e-04 | 1.31e-03 | 29 |
GO:00024837 | Liver | Cirrhotic | antigen processing and presentation of endogenous peptide antigen | 12/4634 | 19/18723 | 4.35e-04 | 3.55e-03 | 12 |
GO:00024747 | Liver | Cirrhotic | antigen processing and presentation of peptide antigen via MHC class I | 15/4634 | 28/18723 | 9.91e-04 | 6.98e-03 | 15 |
GO:001988512 | Liver | Cirrhotic | antigen processing and presentation of endogenous peptide antigen via MHC class I | 10/4634 | 17/18723 | 2.85e-03 | 1.64e-02 | 10 |
GO:00198837 | Liver | Cirrhotic | antigen processing and presentation of endogenous antigen | 13/4634 | 26/18723 | 4.72e-03 | 2.48e-02 | 13 |
GO:00028311 | Liver | Cirrhotic | regulation of response to biotic stimulus | 101/4634 | 327/18723 | 6.58e-03 | 3.25e-02 | 101 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERAP1 | SNV | Missense_Mutation | c.517N>A | p.Glu173Lys | p.E173K | Q9NZ08 | protein_coding | tolerated(0.19) | benign(0.343) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ERAP1 | SNV | Missense_Mutation | c.1867C>A | p.Leu623Ile | p.L623I | Q9NZ08 | protein_coding | tolerated(0.05) | probably_damaging(0.944) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
ERAP1 | SNV | Missense_Mutation | c.1685T>G | p.Leu562Arg | p.L562R | Q9NZ08 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
ERAP1 | SNV | Missense_Mutation | c.1147N>A | p.Glu383Lys | p.E383K | Q9NZ08 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ERAP1 | SNV | Missense_Mutation | c.2150N>T | p.Thr717Ile | p.T717I | Q9NZ08 | protein_coding | tolerated(0.05) | possibly_damaging(0.461) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ERAP1 | SNV | Missense_Mutation | rs144333828 | c.1907G>A | p.Arg636Gln | p.R636Q | Q9NZ08 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ERAP1 | SNV | Missense_Mutation | c.1693N>A | p.Val565Ile | p.V565I | Q9NZ08 | protein_coding | tolerated(1) | benign(0.006) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ERAP1 | SNV | Missense_Mutation | novel | c.716N>T | p.Thr239Ile | p.T239I | Q9NZ08 | protein_coding | deleterious(0.01) | benign(0.361) | TCGA-AG-3893-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR |
ERAP1 | SNV | Missense_Mutation | novel | c.2257A>C | p.Lys753Gln | p.K753Q | Q9NZ08 | protein_coding | tolerated(0.96) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ERAP1 | SNV | Missense_Mutation | novel | c.1889N>T | p.Ala630Val | p.A630V | Q9NZ08 | protein_coding | tolerated(1) | benign(0) | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | TCMDC-124377 | CHEMBL531269 | ||
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | inhibitor | 252166866 | ||
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL2103847 | TOSEDOSTAT | |
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | UMBELLIFERONE | UMBELLIFERONE | ||
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | TCMDC-124673 | CHEMBL587247 | ||
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | inhibitor | 348353641 | ||
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | inhibitor | 348353642 | ||
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | SCOPOLETIN | SCOPOLETIN | ||
51752 | ERAP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | ESCULETIN | ESCULETIN |
Page: 1 |