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Gene: EPB41L5 |
Gene summary for EPB41L5 |
Gene summary. |
Gene information | Species | Human | Gene symbol | EPB41L5 | Gene ID | 57669 |
Gene name | erythrocyte membrane protein band 4.1 like 5 | |
Gene Alias | BE37 | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0000578 | UniProtAcc | Q9HCM4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57669 | EPB41L5 | CCI_1 | Human | Cervix | CC | 1.27e-03 | 6.38e-01 | 0.528 |
57669 | EPB41L5 | AEH-subject1 | Human | Endometrium | AEH | 1.72e-51 | 8.78e-01 | -0.3059 |
57669 | EPB41L5 | AEH-subject2 | Human | Endometrium | AEH | 2.98e-07 | 3.98e-01 | -0.2525 |
57669 | EPB41L5 | AEH-subject3 | Human | Endometrium | AEH | 1.34e-19 | 5.45e-01 | -0.2576 |
57669 | EPB41L5 | AEH-subject4 | Human | Endometrium | AEH | 2.61e-08 | 4.65e-01 | -0.2657 |
57669 | EPB41L5 | AEH-subject5 | Human | Endometrium | AEH | 1.20e-31 | 7.46e-01 | -0.2953 |
57669 | EPB41L5 | EEC-subject1 | Human | Endometrium | EEC | 1.26e-36 | 8.90e-01 | -0.2682 |
57669 | EPB41L5 | EEC-subject2 | Human | Endometrium | EEC | 9.82e-17 | 4.64e-01 | -0.2607 |
57669 | EPB41L5 | EEC-subject3 | Human | Endometrium | EEC | 8.74e-06 | 2.70e-01 | -0.2525 |
57669 | EPB41L5 | EEC-subject4 | Human | Endometrium | EEC | 1.61e-11 | 4.07e-01 | -0.2571 |
57669 | EPB41L5 | EEC-subject5 | Human | Endometrium | EEC | 4.13e-15 | 4.96e-01 | -0.249 |
57669 | EPB41L5 | GSM5276935 | Human | Endometrium | EEC | 2.16e-04 | 1.60e-01 | -0.123 |
57669 | EPB41L5 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.42e-02 | 7.43e-02 | -0.1934 |
57669 | EPB41L5 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.66e-03 | 4.95e-03 | -0.1917 |
57669 | EPB41L5 | LZE4T | Human | Esophagus | ESCC | 2.17e-07 | 3.06e-01 | 0.0811 |
57669 | EPB41L5 | LZE20T | Human | Esophagus | ESCC | 5.83e-03 | 2.56e-01 | 0.0662 |
57669 | EPB41L5 | LZE22T | Human | Esophagus | ESCC | 1.72e-03 | 4.49e-01 | 0.068 |
57669 | EPB41L5 | LZE24T | Human | Esophagus | ESCC | 1.72e-15 | 5.22e-01 | 0.0596 |
57669 | EPB41L5 | P1T-E | Human | Esophagus | ESCC | 9.90e-07 | 7.23e-01 | 0.0875 |
57669 | EPB41L5 | P2T-E | Human | Esophagus | ESCC | 1.17e-20 | 4.34e-01 | 0.1177 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:01501159 | Cervix | CC | cell-substrate junction organization | 37/2311 | 101/18723 | 3.20e-10 | 4.46e-08 | 37 |
GO:00070448 | Cervix | CC | cell-substrate junction assembly | 34/2311 | 95/18723 | 3.35e-09 | 3.45e-07 | 34 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00019528 | Cervix | CC | regulation of cell-matrix adhesion | 40/2311 | 128/18723 | 1.32e-08 | 1.04e-06 | 40 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00071626 | Cervix | CC | negative regulation of cell adhesion | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:00106349 | Cervix | CC | positive regulation of epithelial cell migration | 47/2311 | 176/18723 | 1.73e-07 | 8.01e-06 | 47 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:01501169 | Cervix | CC | regulation of cell-substrate junction organization | 25/2311 | 71/18723 | 5.58e-07 | 2.06e-05 | 25 |
GO:00480417 | Cervix | CC | focal adhesion assembly | 28/2311 | 87/18723 | 9.86e-07 | 3.45e-05 | 28 |
GO:00224084 | Cervix | CC | negative regulation of cell-cell adhesion | 48/2311 | 196/18723 | 1.99e-06 | 6.18e-05 | 48 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EPB41L5 | SNV | Missense_Mutation | rs770943181 | c.43N>T | p.Arg15Cys | p.R15C | Q9HCM4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR |
EPB41L5 | SNV | Missense_Mutation | c.763N>A | p.Leu255Ile | p.L255I | Q9HCM4 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
EPB41L5 | SNV | Missense_Mutation | novel | c.721N>T | p.Asp241Tyr | p.D241Y | Q9HCM4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EPB41L5 | SNV | Missense_Mutation | novel | c.1118N>C | p.Lys373Thr | p.K373T | Q9HCM4 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
EPB41L5 | SNV | Missense_Mutation | c.1498N>A | p.Glu500Lys | p.E500K | Q9HCM4 | protein_coding | tolerated(0.88) | benign(0) | TCGA-D5-6920-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EPB41L5 | SNV | Missense_Mutation | c.794N>C | p.Leu265Ser | p.L265S | Q9HCM4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EPB41L5 | SNV | Missense_Mutation | novel | c.337N>T | p.Pro113Ser | p.P113S | Q9HCM4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6317-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | PD |
EPB41L5 | SNV | Missense_Mutation | c.421N>A | p.Leu141Ile | p.L141I | Q9HCM4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EPB41L5 | deletion | Frame_Shift_Del | c.796delN | p.Trp268GlyfsTer4 | p.W268Gfs*4 | Q9HCM4 | protein_coding | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
EPB41L5 | insertion | Frame_Shift_Ins | novel | c.186dupA | p.Ala63SerfsTer8 | p.A63Sfs*8 | Q9HCM4 | protein_coding | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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