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Gene: ENKD1 |
Gene summary for ENKD1 |
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Gene information | Species | Human | Gene symbol | ENKD1 | Gene ID | 84080 |
Gene name | enkurin domain containing 1 | |
Gene Alias | C16orf48 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H0I2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84080 | ENKD1 | HCC1_Meng | Human | Liver | HCC | 4.84e-02 | -5.16e-02 | 0.0246 |
84080 | ENKD1 | HCC2_Meng | Human | Liver | HCC | 4.41e-06 | 5.30e-02 | 0.0107 |
84080 | ENKD1 | HCC2 | Human | Liver | HCC | 2.91e-03 | 2.19e+00 | 0.5341 |
84080 | ENKD1 | S014 | Human | Liver | HCC | 2.74e-02 | 1.21e-01 | 0.2254 |
84080 | ENKD1 | S028 | Human | Liver | HCC | 1.30e-14 | 5.34e-01 | 0.2503 |
84080 | ENKD1 | S029 | Human | Liver | HCC | 1.13e-08 | 3.65e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENKD1 | SNV | Missense_Mutation | novel | c.562N>T | p.Pro188Ser | p.P188S | Q9H0I2 | protein_coding | tolerated(0.49) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENKD1 | SNV | Missense_Mutation | novel | c.812N>T | p.Ala271Val | p.A271V | Q9H0I2 | protein_coding | tolerated(0.25) | benign(0.061) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENKD1 | SNV | Missense_Mutation | c.832C>T | p.Arg278Cys | p.R278C | Q9H0I2 | protein_coding | tolerated(0.15) | possibly_damaging(0.471) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENKD1 | SNV | Missense_Mutation | novel | c.232N>A | p.Leu78Met | p.L78M | Q9H0I2 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENKD1 | SNV | Missense_Mutation | rs763488576 | c.850C>T | p.Arg284Trp | p.R284W | Q9H0I2 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENKD1 | SNV | Missense_Mutation | rs772586530 | c.998N>C | p.Lys333Thr | p.K333T | Q9H0I2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ENKD1 | SNV | Missense_Mutation | rs373303243 | c.719N>T | p.Thr240Met | p.T240M | Q9H0I2 | protein_coding | tolerated(0.21) | possibly_damaging(0.607) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENKD1 | SNV | Missense_Mutation | rs747403734 | c.404N>A | p.Arg135His | p.R135H | Q9H0I2 | protein_coding | tolerated(0.11) | benign(0) | TCGA-05-4415-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ENKD1 | SNV | Missense_Mutation | c.259N>T | p.Gly87Cys | p.G87C | Q9H0I2 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ENKD1 | SNV | Missense_Mutation | novel | c.100N>C | p.Glu34Gln | p.E34Q | Q9H0I2 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-62-8399-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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