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Gene: EIF5AL1 |
Gene summary for EIF5AL1 |
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Gene information | Species | Human | Gene symbol | EIF5AL1 | Gene ID | 143244 |
Gene name | eukaryotic translation initiation factor 5A like 1 | |
Gene Alias | EIF5A | |
Cytomap | 10q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | Q6IS14 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
143244 | EIF5AL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.47e-03 | 1.06e-01 | 0.0155 |
143244 | EIF5AL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.91e-12 | 3.38e-01 | -0.1808 |
143244 | EIF5AL1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.49e-08 | 4.13e-01 | 0.0216 |
143244 | EIF5AL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.53e-23 | 6.13e-01 | -0.0811 |
143244 | EIF5AL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.65e-10 | 2.61e-01 | -0.1088 |
143244 | EIF5AL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.28e-26 | 4.77e-01 | -0.1954 |
143244 | EIF5AL1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-11 | 6.29e-01 | -0.2602 |
143244 | EIF5AL1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.88e-13 | 5.57e-01 | -0.2196 |
143244 | EIF5AL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.27e-16 | 6.37e-01 | -0.1207 |
143244 | EIF5AL1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.16e-09 | 3.20e-01 | -0.1526 |
143244 | EIF5AL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.63e-19 | 3.55e-01 | -0.1464 |
143244 | EIF5AL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.42e-14 | 2.99e-01 | -0.1001 |
143244 | EIF5AL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.57e-34 | 7.52e-01 | -0.059 |
143244 | EIF5AL1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.44e-09 | 5.04e-01 | -0.1706 |
143244 | EIF5AL1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.03e-06 | 4.38e-01 | -0.1462 |
143244 | EIF5AL1 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.36e-09 | 3.30e-01 | -0.0842 |
143244 | EIF5AL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.43e-19 | 4.56e-01 | 0.096 |
143244 | EIF5AL1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.20e-01 | 0.0446 |
143244 | EIF5AL1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.14e-04 | 2.03e-01 | 0.0528 |
143244 | EIF5AL1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-09 | 3.81e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0050658 | Colorectum | AD | RNA transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0034250 | Colorectum | AD | positive regulation of cellular amide metabolic process | 53/3918 | 162/18723 | 2.98e-04 | 3.60e-03 | 53 |
GO:0043244 | Colorectum | AD | regulation of protein-containing complex disassembly | 41/3918 | 121/18723 | 6.22e-04 | 6.48e-03 | 41 |
GO:0043624 | Colorectum | AD | cellular protein complex disassembly | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
GO:0045727 | Colorectum | AD | positive regulation of translation | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
GO:0051028 | Colorectum | AD | mRNA transport | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
GO:0006414 | Colorectum | AD | translational elongation | 21/3918 | 55/18723 | 2.53e-03 | 1.93e-02 | 21 |
GO:0043243 | Colorectum | AD | positive regulation of protein-containing complex disassembly | 14/3918 | 35/18723 | 7.92e-03 | 4.73e-02 | 14 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
GO:00064031 | Colorectum | SER | RNA localization | 53/2897 | 201/18723 | 4.51e-05 | 1.13e-03 | 53 |
GO:00436241 | Colorectum | SER | cellular protein complex disassembly | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00159311 | Colorectum | SER | nucleobase-containing compound transport | 54/2897 | 222/18723 | 3.65e-04 | 5.67e-03 | 54 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF5AL1 | SNV | Missense_Mutation | c.380N>C | p.Tyr127Ser | p.Y127S | Q6IS14 | protein_coding | deleterious(0.01) | benign(0.224) | TCGA-DD-AAD0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EIF5AL1 | SNV | Missense_Mutation | c.218N>A | p.Cys73Tyr | p.C73Y | Q6IS14 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EIF5AL1 | SNV | Missense_Mutation | novel | c.155N>A | p.Gly52Asp | p.G52D | Q6IS14 | protein_coding | deleterious(0.02) | probably_damaging(0.976) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF5AL1 | SNV | Missense_Mutation | novel | c.278G>T | p.Gly93Val | p.G93V | Q6IS14 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF5AL1 | SNV | Missense_Mutation | c.242N>C | p.Val81Ala | p.V81A | Q6IS14 | protein_coding | deleterious(0.02) | possibly_damaging(0.576) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EIF5AL1 | SNV | Missense_Mutation | c.265N>C | p.Phe89Leu | p.F89L | Q6IS14 | protein_coding | tolerated(0.06) | benign(0.229) | TCGA-BR-A4QI-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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