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Gene: EIF5A2 |
Gene summary for EIF5A2 |
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Gene information | Species | Human | Gene symbol | EIF5A2 | Gene ID | 56648 |
Gene name | eukaryotic translation initiation factor 5A2 | |
Gene Alias | EIF-5A2 | |
Cytomap | 3q26.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9GZV4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56648 | EIF5A2 | LZE4T | Human | Esophagus | ESCC | 4.59e-06 | 2.58e-01 | 0.0811 |
56648 | EIF5A2 | LZE7T | Human | Esophagus | ESCC | 8.66e-05 | 2.86e-01 | 0.0667 |
56648 | EIF5A2 | LZE24T | Human | Esophagus | ESCC | 1.19e-07 | 2.14e-01 | 0.0596 |
56648 | EIF5A2 | LZE6T | Human | Esophagus | ESCC | 6.51e-06 | 3.23e-01 | 0.0845 |
56648 | EIF5A2 | P1T-E | Human | Esophagus | ESCC | 9.03e-04 | 1.90e-01 | 0.0875 |
56648 | EIF5A2 | P2T-E | Human | Esophagus | ESCC | 2.91e-27 | 4.94e-01 | 0.1177 |
56648 | EIF5A2 | P4T-E | Human | Esophagus | ESCC | 9.19e-11 | 2.22e-01 | 0.1323 |
56648 | EIF5A2 | P5T-E | Human | Esophagus | ESCC | 2.74e-10 | 2.68e-01 | 0.1327 |
56648 | EIF5A2 | P8T-E | Human | Esophagus | ESCC | 7.19e-06 | 2.21e-01 | 0.0889 |
56648 | EIF5A2 | P9T-E | Human | Esophagus | ESCC | 6.00e-08 | 2.21e-01 | 0.1131 |
56648 | EIF5A2 | P10T-E | Human | Esophagus | ESCC | 1.02e-17 | 3.29e-01 | 0.116 |
56648 | EIF5A2 | P11T-E | Human | Esophagus | ESCC | 7.86e-11 | 5.53e-01 | 0.1426 |
56648 | EIF5A2 | P12T-E | Human | Esophagus | ESCC | 1.04e-31 | 6.74e-01 | 0.1122 |
56648 | EIF5A2 | P15T-E | Human | Esophagus | ESCC | 7.80e-11 | 3.24e-01 | 0.1149 |
56648 | EIF5A2 | P16T-E | Human | Esophagus | ESCC | 6.71e-11 | 1.32e-01 | 0.1153 |
56648 | EIF5A2 | P17T-E | Human | Esophagus | ESCC | 1.36e-08 | 2.53e-01 | 0.1278 |
56648 | EIF5A2 | P21T-E | Human | Esophagus | ESCC | 2.02e-15 | 3.64e-01 | 0.1617 |
56648 | EIF5A2 | P22T-E | Human | Esophagus | ESCC | 7.73e-18 | 3.79e-01 | 0.1236 |
56648 | EIF5A2 | P23T-E | Human | Esophagus | ESCC | 4.15e-10 | 2.52e-01 | 0.108 |
56648 | EIF5A2 | P24T-E | Human | Esophagus | ESCC | 1.85e-05 | 1.04e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:0045727111 | Esophagus | ESCC | positive regulation of translation | 107/8552 | 136/18723 | 2.79e-15 | 1.68e-13 | 107 |
GO:0034250111 | Esophagus | ESCC | positive regulation of cellular amide metabolic process | 123/8552 | 162/18723 | 3.32e-15 | 1.93e-13 | 123 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:00432446 | Esophagus | ESCC | regulation of protein-containing complex disassembly | 75/8552 | 121/18723 | 2.17e-04 | 1.36e-03 | 75 |
GO:00436245 | Esophagus | ESCC | cellular protein complex disassembly | 78/8552 | 136/18723 | 4.00e-03 | 1.62e-02 | 78 |
GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
GO:000640318 | Oral cavity | OSCC | RNA localization | 150/7305 | 201/18723 | 6.90e-25 | 1.98e-22 | 150 |
GO:00510287 | Oral cavity | OSCC | mRNA transport | 101/7305 | 130/18723 | 2.19e-19 | 3.15e-17 | 101 |
GO:005065714 | Oral cavity | OSCC | nucleic acid transport | 120/7305 | 163/18723 | 2.31e-19 | 3.18e-17 | 120 |
GO:005065814 | Oral cavity | OSCC | RNA transport | 120/7305 | 163/18723 | 2.31e-19 | 3.18e-17 | 120 |
GO:005123614 | Oral cavity | OSCC | establishment of RNA localization | 121/7305 | 166/18723 | 6.38e-19 | 8.24e-17 | 121 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF5A2 | SNV | Missense_Mutation | rs761918940 | c.325C>T | p.Arg109Cys | p.R109C | Q9GZV4 | protein_coding | deleterious(0.02) | benign(0.222) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
EIF5A2 | SNV | Missense_Mutation | c.41C>A | p.Ala14Asp | p.A14D | Q9GZV4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-A494-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF5A2 | SNV | Missense_Mutation | novel | c.184N>C | p.Asp62His | p.D62H | Q9GZV4 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-62-A46R-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF5A2 | SNV | Missense_Mutation | novel | c.383N>T | p.Asn128Ile | p.N128I | Q9GZV4 | protein_coding | deleterious(0.01) | benign(0.178) | TCGA-69-7974-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
EIF5A2 | SNV | Missense_Mutation | c.203N>C | p.Lys68Thr | p.K68T | Q9GZV4 | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-60-2722-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD | |
EIF5A2 | SNV | Missense_Mutation | novel | c.313A>G | p.Thr105Ala | p.T105A | Q9GZV4 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-NC-A5HE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF5A2 | SNV | Missense_Mutation | novel | c.150G>T | p.Lys50Asn | p.K50N | Q9GZV4 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-BA-A6DJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
EIF5A2 | SNV | Missense_Mutation | rs865793416 | c.197N>A | p.Gly66Asp | p.G66D | Q9GZV4 | protein_coding | deleterious(0) | benign(0.373) | TCGA-FC-A5OB-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | lupron | SD |
EIF5A2 | SNV | Missense_Mutation | c.164N>G | p.Lys55Arg | p.K55R | Q9GZV4 | protein_coding | deleterious(0) | possibly_damaging(0.711) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
EIF5A2 | deletion | Frame_Shift_Del | c.83delN | p.Asn28ThrfsTer13 | p.N28Tfs*13 | Q9GZV4 | protein_coding | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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