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Gene: EIF3L |
Gene summary for EIF3L |
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Gene information | Species | Human | Gene symbol | EIF3L | Gene ID | 51386 |
Gene name | eukaryotic translation initiation factor 3 subunit L | |
Gene Alias | EIF3EIP | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001732 | UniProtAcc | Q9Y262 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51386 | EIF3L | GSM4909286 | Human | Breast | IDC | 4.31e-31 | 6.07e-01 | 0.1081 |
51386 | EIF3L | GSM4909287 | Human | Breast | IDC | 2.05e-07 | -4.21e-01 | 0.2057 |
51386 | EIF3L | GSM4909291 | Human | Breast | IDC | 2.21e-06 | -4.81e-01 | 0.1753 |
51386 | EIF3L | GSM4909293 | Human | Breast | IDC | 6.42e-18 | -3.62e-01 | 0.1581 |
51386 | EIF3L | GSM4909294 | Human | Breast | IDC | 8.35e-16 | -4.26e-01 | 0.2022 |
51386 | EIF3L | GSM4909296 | Human | Breast | IDC | 3.56e-20 | -5.07e-01 | 0.1524 |
51386 | EIF3L | GSM4909297 | Human | Breast | IDC | 3.38e-23 | -2.47e-01 | 0.1517 |
51386 | EIF3L | GSM4909301 | Human | Breast | IDC | 1.29e-35 | -6.91e-01 | 0.1577 |
51386 | EIF3L | GSM4909302 | Human | Breast | IDC | 1.62e-12 | -5.08e-01 | 0.1545 |
51386 | EIF3L | GSM4909304 | Human | Breast | IDC | 3.30e-07 | -2.70e-01 | 0.1636 |
51386 | EIF3L | GSM4909305 | Human | Breast | IDC | 2.67e-02 | 2.94e-01 | 0.0436 |
51386 | EIF3L | GSM4909307 | Human | Breast | IDC | 3.69e-17 | -5.10e-01 | 0.1569 |
51386 | EIF3L | GSM4909308 | Human | Breast | IDC | 2.92e-05 | -2.78e-01 | 0.158 |
51386 | EIF3L | GSM4909309 | Human | Breast | IDC | 1.21e-12 | -5.28e-01 | 0.0483 |
51386 | EIF3L | GSM4909311 | Human | Breast | IDC | 6.17e-48 | -5.25e-01 | 0.1534 |
51386 | EIF3L | GSM4909312 | Human | Breast | IDC | 3.60e-18 | 1.49e-01 | 0.1552 |
51386 | EIF3L | GSM4909313 | Human | Breast | IDC | 4.53e-03 | -1.97e-02 | 0.0391 |
51386 | EIF3L | GSM4909315 | Human | Breast | IDC | 3.13e-08 | -3.70e-01 | 0.21 |
51386 | EIF3L | GSM4909316 | Human | Breast | IDC | 5.82e-03 | -4.42e-01 | 0.21 |
51386 | EIF3L | GSM4909317 | Human | Breast | IDC | 1.20e-03 | -3.33e-01 | 0.1355 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
GO:00064138 | Breast | Precancer | translational initiation | 30/1080 | 118/18723 | 3.23e-12 | 5.58e-10 | 30 |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00021838 | Breast | Precancer | cytoplasmic translational initiation | 11/1080 | 34/18723 | 1.87e-06 | 6.63e-05 | 11 |
GO:00017328 | Breast | Precancer | formation of cytoplasmic translation initiation complex | 7/1080 | 16/18723 | 1.50e-05 | 3.71e-04 | 7 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:007182614 | Breast | IDC | ribonucleoprotein complex subunit organization | 52/1434 | 227/18723 | 5.18e-13 | 1.21e-10 | 52 |
GO:002261814 | Breast | IDC | ribonucleoprotein complex assembly | 51/1434 | 220/18723 | 5.32e-13 | 1.21e-10 | 51 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:000641313 | Breast | IDC | translational initiation | 31/1434 | 118/18723 | 7.29e-10 | 7.52e-08 | 31 |
GO:000218313 | Breast | IDC | cytoplasmic translational initiation | 12/1434 | 34/18723 | 4.35e-06 | 1.53e-04 | 12 |
GO:000173213 | Breast | IDC | formation of cytoplasmic translation initiation complex | 8/1434 | 16/18723 | 8.56e-06 | 2.47e-04 | 8 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:002261324 | Breast | DCIS | ribonucleoprotein complex biogenesis | 83/1390 | 463/18723 | 3.65e-14 | 1.09e-11 | 83 |
GO:007182624 | Breast | DCIS | ribonucleoprotein complex subunit organization | 52/1390 | 227/18723 | 1.54e-13 | 3.95e-11 | 52 |
GO:002261824 | Breast | DCIS | ribonucleoprotein complex assembly | 51/1390 | 220/18723 | 1.60e-13 | 3.95e-11 | 51 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF3L | SNV | Missense_Mutation | c.1626N>A | p.Phe542Leu | p.F542L | Q9Y262 | protein_coding | deleterious(0.01) | possibly_damaging(0.528) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
EIF3L | SNV | Missense_Mutation | c.1243N>C | p.Tyr415His | p.Y415H | Q9Y262 | protein_coding | tolerated(0.15) | possibly_damaging(0.744) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
EIF3L | SNV | Missense_Mutation | c.1009N>A | p.Ala337Thr | p.A337T | Q9Y262 | protein_coding | tolerated(0.8) | benign(0.012) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EIF3L | SNV | Missense_Mutation | c.386N>C | p.Leu129Pro | p.L129P | Q9Y262 | protein_coding | deleterious(0) | possibly_damaging(0.534) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF3L | SNV | Missense_Mutation | rs760820592 | c.892G>A | p.Glu298Lys | p.E298K | Q9Y262 | protein_coding | deleterious(0.03) | possibly_damaging(0.636) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
EIF3L | SNV | Missense_Mutation | novel | c.829N>T | p.Leu277Phe | p.L277F | Q9Y262 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF3L | SNV | Missense_Mutation | rs760820592 | c.892G>A | p.Glu298Lys | p.E298K | Q9Y262 | protein_coding | deleterious(0.03) | possibly_damaging(0.636) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF3L | SNV | Missense_Mutation | c.885G>T | p.Glu295Asp | p.E295D | Q9Y262 | protein_coding | tolerated(0.32) | possibly_damaging(0.529) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
EIF3L | SNV | Missense_Mutation | rs766324137 | c.784N>T | p.Arg262Trp | p.R262W | Q9Y262 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
EIF3L | SNV | Missense_Mutation | rs368635683 | c.1664N>A | p.Arg555Gln | p.R555Q | Q9Y262 | protein_coding | tolerated(0.11) | benign(0.295) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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