![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: EIF2B5 |
Gene summary for EIF2B5 |
![]() |
Gene information | Species | Human | Gene symbol | EIF2B5 | Gene ID | 8893 |
Gene name | eukaryotic translation initiation factor 2B subunit epsilon | |
Gene Alias | CACH | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q13144 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8893 | EIF2B5 | LZE4T | Human | Esophagus | ESCC | 1.11e-07 | 2.83e-01 | 0.0811 |
8893 | EIF2B5 | LZE5T | Human | Esophagus | ESCC | 3.74e-05 | 4.70e-01 | 0.0514 |
8893 | EIF2B5 | LZE7T | Human | Esophagus | ESCC | 1.80e-10 | 3.76e-01 | 0.0667 |
8893 | EIF2B5 | LZE8T | Human | Esophagus | ESCC | 2.03e-03 | 1.71e-01 | 0.067 |
8893 | EIF2B5 | LZE20T | Human | Esophagus | ESCC | 1.74e-10 | 2.46e-01 | 0.0662 |
8893 | EIF2B5 | LZE22T | Human | Esophagus | ESCC | 1.19e-07 | 4.93e-01 | 0.068 |
8893 | EIF2B5 | LZE24T | Human | Esophagus | ESCC | 1.14e-20 | 5.39e-01 | 0.0596 |
8893 | EIF2B5 | LZE21T | Human | Esophagus | ESCC | 1.92e-07 | 6.60e-01 | 0.0655 |
8893 | EIF2B5 | P1T-E | Human | Esophagus | ESCC | 3.36e-18 | 7.71e-01 | 0.0875 |
8893 | EIF2B5 | P2T-E | Human | Esophagus | ESCC | 2.33e-52 | 1.04e+00 | 0.1177 |
8893 | EIF2B5 | P4T-E | Human | Esophagus | ESCC | 4.39e-56 | 1.43e+00 | 0.1323 |
8893 | EIF2B5 | P5T-E | Human | Esophagus | ESCC | 8.94e-16 | 4.54e-01 | 0.1327 |
8893 | EIF2B5 | P8T-E | Human | Esophagus | ESCC | 3.21e-32 | 7.03e-01 | 0.0889 |
8893 | EIF2B5 | P9T-E | Human | Esophagus | ESCC | 4.78e-30 | 6.19e-01 | 0.1131 |
8893 | EIF2B5 | P10T-E | Human | Esophagus | ESCC | 1.65e-40 | 7.17e-01 | 0.116 |
8893 | EIF2B5 | P11T-E | Human | Esophagus | ESCC | 6.20e-18 | 9.60e-01 | 0.1426 |
8893 | EIF2B5 | P12T-E | Human | Esophagus | ESCC | 7.52e-25 | 6.27e-01 | 0.1122 |
8893 | EIF2B5 | P15T-E | Human | Esophagus | ESCC | 9.74e-47 | 8.39e-01 | 0.1149 |
8893 | EIF2B5 | P16T-E | Human | Esophagus | ESCC | 3.32e-39 | 7.18e-01 | 0.1153 |
8893 | EIF2B5 | P17T-E | Human | Esophagus | ESCC | 1.83e-08 | 2.29e-01 | 0.1278 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:0045727111 | Esophagus | ESCC | positive regulation of translation | 107/8552 | 136/18723 | 2.79e-15 | 1.68e-13 | 107 |
GO:0034250111 | Esophagus | ESCC | positive regulation of cellular amide metabolic process | 123/8552 | 162/18723 | 3.32e-15 | 1.93e-13 | 123 |
GO:000644617 | Esophagus | ESCC | regulation of translational initiation | 65/8552 | 79/18723 | 2.04e-11 | 7.07e-10 | 65 |
GO:0009408110 | Esophagus | ESCC | response to heat | 77/8552 | 110/18723 | 2.01e-07 | 3.11e-06 | 77 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:000756820 | Esophagus | ESCC | aging | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:000926619 | Esophagus | ESCC | response to temperature stimulus | 106/8552 | 178/18723 | 1.30e-04 | 8.84e-04 | 106 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:00459483 | Esophagus | ESCC | positive regulation of translational initiation | 23/8552 | 30/18723 | 5.47e-04 | 3.00e-03 | 23 |
GO:00508528 | Esophagus | ESCC | T cell receptor signaling pathway | 73/8552 | 123/18723 | 1.54e-03 | 7.24e-03 | 73 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF2B5 | SNV | Missense_Mutation | c.902N>G | p.Ser301Cys | p.S301C | Q13144 | protein_coding | tolerated(0.09) | benign(0.042) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
EIF2B5 | SNV | Missense_Mutation | novel | c.507G>T | p.Arg169Ser | p.R169S | Q13144 | protein_coding | deleterious(0) | benign(0.165) | TCGA-EK-A2PK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EIF2B5 | SNV | Missense_Mutation | novel | c.1135N>C | p.Ile379Leu | p.I379L | Q13144 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EIF2B5 | SNV | Missense_Mutation | novel | c.796N>C | p.Tyr266His | p.Y266H | Q13144 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
EIF2B5 | SNV | Missense_Mutation | novel | c.440A>C | p.Asp147Ala | p.D147A | Q13144 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3858-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EIF2B5 | SNV | Missense_Mutation | rs113994055 | c.583C>T | p.Arg195Cys | p.R195C | Q13144 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
EIF2B5 | SNV | Missense_Mutation | novel | c.245N>C | p.Phe82Ser | p.F82S | Q13144 | protein_coding | tolerated(0.11) | probably_damaging(0.915) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EIF2B5 | SNV | Missense_Mutation | c.1491G>C | p.Trp497Cys | p.W497C | Q13144 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD | |
EIF2B5 | SNV | Missense_Mutation | rs113994046 | c.220N>A | p.Ala74Thr | p.A74T | Q13144 | protein_coding | tolerated(0.13) | possibly_damaging(0.622) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EIF2B5 | SNV | Missense_Mutation | rs373147037 | c.514C>T | p.Arg172Trp | p.R172W | Q13144 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |