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Gene: EIF2B4 |
Gene summary for EIF2B4 |
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Gene information | Species | Human | Gene symbol | EIF2B4 | Gene ID | 8890 |
Gene name | eukaryotic translation initiation factor 2B subunit delta | |
Gene Alias | EIF-2B | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UI10 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8890 | EIF2B4 | LZE2T | Human | Esophagus | ESCC | 8.09e-03 | 3.05e-01 | 0.082 |
8890 | EIF2B4 | LZE4T | Human | Esophagus | ESCC | 6.57e-04 | 2.44e-01 | 0.0811 |
8890 | EIF2B4 | LZE7T | Human | Esophagus | ESCC | 2.50e-02 | 1.57e-01 | 0.0667 |
8890 | EIF2B4 | LZE8T | Human | Esophagus | ESCC | 1.67e-03 | 5.71e-02 | 0.067 |
8890 | EIF2B4 | LZE22T | Human | Esophagus | ESCC | 4.06e-02 | 1.98e-01 | 0.068 |
8890 | EIF2B4 | LZE24T | Human | Esophagus | ESCC | 4.98e-08 | 2.32e-01 | 0.0596 |
8890 | EIF2B4 | P1T-E | Human | Esophagus | ESCC | 2.22e-04 | 2.38e-01 | 0.0875 |
8890 | EIF2B4 | P2T-E | Human | Esophagus | ESCC | 1.71e-32 | 5.21e-01 | 0.1177 |
8890 | EIF2B4 | P4T-E | Human | Esophagus | ESCC | 9.26e-21 | 4.24e-01 | 0.1323 |
8890 | EIF2B4 | P5T-E | Human | Esophagus | ESCC | 2.06e-15 | 1.90e-01 | 0.1327 |
8890 | EIF2B4 | P8T-E | Human | Esophagus | ESCC | 2.80e-15 | 1.67e-01 | 0.0889 |
8890 | EIF2B4 | P9T-E | Human | Esophagus | ESCC | 4.99e-08 | 1.43e-01 | 0.1131 |
8890 | EIF2B4 | P10T-E | Human | Esophagus | ESCC | 1.90e-25 | 2.63e-01 | 0.116 |
8890 | EIF2B4 | P11T-E | Human | Esophagus | ESCC | 1.45e-11 | 4.63e-01 | 0.1426 |
8890 | EIF2B4 | P12T-E | Human | Esophagus | ESCC | 3.78e-28 | 5.14e-01 | 0.1122 |
8890 | EIF2B4 | P15T-E | Human | Esophagus | ESCC | 8.49e-16 | 3.29e-01 | 0.1149 |
8890 | EIF2B4 | P16T-E | Human | Esophagus | ESCC | 2.45e-18 | 2.96e-01 | 0.1153 |
8890 | EIF2B4 | P17T-E | Human | Esophagus | ESCC | 2.59e-02 | 1.90e-01 | 0.1278 |
8890 | EIF2B4 | P19T-E | Human | Esophagus | ESCC | 1.84e-04 | 6.35e-01 | 0.1662 |
8890 | EIF2B4 | P20T-E | Human | Esophagus | ESCC | 2.13e-16 | 3.02e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:0009408110 | Esophagus | ESCC | response to heat | 77/8552 | 110/18723 | 2.01e-07 | 3.11e-06 | 77 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:000926619 | Esophagus | ESCC | response to temperature stimulus | 106/8552 | 178/18723 | 1.30e-04 | 8.84e-04 | 106 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:00508528 | Esophagus | ESCC | T cell receptor signaling pathway | 73/8552 | 123/18723 | 1.54e-03 | 7.24e-03 | 73 |
GO:0009743111 | Esophagus | ESCC | response to carbohydrate | 135/8552 | 253/18723 | 8.16e-03 | 2.89e-02 | 135 |
GO:00487092 | Esophagus | ESCC | oligodendrocyte differentiation | 55/8552 | 95/18723 | 1.10e-02 | 3.72e-02 | 55 |
GO:000641312 | Liver | Cirrhotic | translational initiation | 76/4634 | 118/18723 | 8.36e-20 | 2.18e-17 | 76 |
GO:000641712 | Liver | Cirrhotic | regulation of translation | 194/4634 | 468/18723 | 7.28e-16 | 8.79e-14 | 194 |
GO:000974312 | Liver | Cirrhotic | response to carbohydrate | 101/4634 | 253/18723 | 6.24e-08 | 1.92e-06 | 101 |
GO:004343412 | Liver | Cirrhotic | response to peptide hormone | 149/4634 | 414/18723 | 1.70e-07 | 4.49e-06 | 149 |
GO:003428412 | Liver | Cirrhotic | response to monosaccharide | 90/4634 | 225/18723 | 2.87e-07 | 7.01e-06 | 90 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF2B4 | SNV | Missense_Mutation | novel | c.536N>G | p.Leu179Arg | p.L179R | protein_coding | tolerated(0.59) | benign(0.275) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF2B4 | SNV | Missense_Mutation | rs774864445 | c.398N>A | p.Arg133Gln | p.R133Q | protein_coding | deleterious(0.01) | possibly_damaging(0.559) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF2B4 | SNV | Missense_Mutation | c.1392N>A | p.Phe464Leu | p.F464L | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | ||
EIF2B4 | SNV | Missense_Mutation | c.1478N>T | p.Ala493Val | p.A493V | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EIF2B4 | SNV | Missense_Mutation | c.631A>G | p.Asn211Asp | p.N211D | protein_coding | tolerated(0.33) | benign(0.021) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
EIF2B4 | SNV | Missense_Mutation | rs746547024 | c.568A>G | p.Thr190Ala | p.T190A | protein_coding | tolerated(0.76) | benign(0.05) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
EIF2B4 | SNV | Missense_Mutation | rs141025043 | c.1094G>A | p.Arg365Gln | p.R365Q | protein_coding | tolerated(0.31) | benign(0.009) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
EIF2B4 | SNV | Missense_Mutation | rs759071387 | c.1312N>T | p.Arg438Trp | p.R438W | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2Y-A9H7-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EIF2B4 | SNV | Missense_Mutation | novel | c.980G>T | p.Arg327Leu | p.R327L | protein_coding | tolerated(0.09) | benign(0.03) | TCGA-05-4249-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EIF2B4 | SNV | Missense_Mutation | c.1385N>G | p.Tyr462Cys | p.Y462C | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-49-6745-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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